COVID-19 vaccine and menstrual conditions in female: data analysis of the Vaccine Adverse Event Reporting System (VAERS)

Abstract

Background In reports of adverse reactions following vaccination with the coronavirus disease 2019(COVID-19) vaccines, there have been fewer reports of concern for menstrual disorders in female. Objective Our study employed Vaccine Adverse Event Reporting System (VAERS) to investigate and analyze the relationship between COVID-19 Vaccines and menstrual disorders in female. Methods We collected reports of menstrual disorders in VAERS from July 2, 1990 to November 12, 2021, and performed a stratified analysis. The potential relationship between COVID-19 vaccine and reports of menstrual disorders was evaluated using the Reporting Odds Ratio (ROR) method. Results A total of 14,431 reports of menstrual disorders were included in the study, and 13,118 were associated with COVID-19 vaccine. The ROR was 7.83 (95% confidence interval [95%CI]: 7.39–8.28). The most commonly reported event was Menstruation irregular (4998 reports), and a higher percentage of female aged 30–49 years reported menstrual disorders (42.55%) after exposure to COVID-19 Vaccines. Both for all reports of menstrual disorders (ROR = 5.82; 95%CI: 4.93–6.95) and excluding reports of unknown age (ROR = 13.02; 95%CI: 10.89–15.56),suggest that female age may be associated with menstrual disorders after vaccination with the COVID-19 Vaccines. Conclusion There is a potential safety signal when the COVID-19 vaccine is administered to young adult female (30–49 years old), resulting in menstrual disorders in. However, due to the well-known limitations of spontaneous reporting data, it is challenging to explicity classify menstrual disorders as an adverse event of the COVID-19 Vaccines, and reports of adverse reactions to COVID-19 Vaccines in this age group should continue to be tracked.

Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

“…The specific mechanisms through which COVID-19 vaccines may trigger autoimmune reactions are unknown. The COVID-19 vaccine has been related to an increase in the occurrence of blistering illnesses such as bullous pemphigoid [ 22 ]. After COVID-19 immunization, there was a significant clonality of T cells reacting to SARS-CoV-2-associated epitopes in lesions from patients with new-onset bullous pemphigoid, which was not the case before COVID-19 mass immunizations.…”

“…The majority of NCDs associated with COVID-19 vaccines account for: (1) CVDs including hypertension, myocarditis, infarctions, thromboembolic events, and arrhythmia [ 3 , 8 , 9 , 10 ]; (2) premature obesity and diabetes [ 11 , 12 , 13 , 14 , 15 ]; (3) acute kidney disorders (AKDs) [ 16 ]; and (4) premature neurodegeneration and mental disorders [ 17 , 18 , 19 , 20 , 21 ], and autoimmune spectrum disorders including vaccine-induced immune thrombotic thrombocytopenia (VITT) and leukocytoclastic vasculitis [ 22 , 23 ]. Other systemic adverse reactions such as fever, headache, widespread fatigue, chills, arthralgia, muscular pain, and nausea [ 24 ] are transient and not discussed in this review.…”

Association between SARS-CoV-2 vaccination and healthcare contacts for menstrual disturbance and bleeding in women before and after menopause: nationwide, register based cohort study

“…The concern for an association between SARS-CoV-2 vaccination and menstrual or bleeding disturbances in women has been triggered by the large number of spontaneous case reports related to such conditions. [1][2][3]10 Also, several studies on selfreported menstruation cycles changes after SARS-CoV-2 vaccination have been published. 4-9 27 28 The European Medicines Agency has recommended that heavy menstrual bleeding should be acknowledged as a side effect of both SARS-CoV-2 mRNA vaccines.…”

“…The US Vaccine Adverse Event Reporting System, the UK Medicines and Healthcare Products Regulatory Agency's Yellow Card surveillance scheme, and the Swedish Medical Products Agency have received many reports of menstrual disturbance after SARS-CoV-2 vaccination via their respective pharmacovigilance systems. [1][2][3] Several studies on self-reported menstruation cycles after SARS-CoV-2 vaccination, from survey data and a menstrual cycle tracking app, indicate changes in menstruation cycles. [4][5][6][7][8][9] A link between SARS-CoV-2 vaccination and menstrual disturbance has also doi: 10.1136/bmj-2023-074778 | BMJ 2023;381:e074778 | the bmj been widely discussed on social media.…”

“…Menstrual disturbances such as excessive, frequent, and irregular menstruation or absent, scant, and rare menstruation have been reported in association with SARS-CoV-2 vaccines. The US Vaccine Adverse Event Reporting System, the UK Medicines and Healthcare Products Regulatory Agency’s Yellow Card surveillance scheme, and the Swedish Medical Products Agency have received many reports of menstrual disturbance after SARS-CoV-2 vaccination via their respective pharmacovigilance systems 123…”