COVID-19 vaccine and male reproductive health (preliminary data)

Elagin, V.V.; Adamyan, L.V.; Вечорко, В.И.; Дорошенко, Д.А.; Dashko, A.A.; Филиппов, О.С.; Stepanian, A.A.; Medvedeva, I.V.

doi:10.17116/repro2021270410

Cited by 6 publications

(12 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 Changes in sex hormones have also been reported in research on the non-replicating viral vector vaccine, Sputnik V. 15 The authors observed a statistically significant positive trend in the increase in the level of estradiol (E2) and a slight decrease in the level of prolactin (PRL) and total T after Sputnik V vaccination, but they hold these changes have no clinical significance due to the absence of changes in semen parameters at all stages of their study. 15 In short, the jury is still out on the impact of the COVID-19 vaccine on male fertility. As inactivated vaccines with some unique advantages such as mature manufacturing processes and ease of scaling up production and storage, Sinovac and Sinopharm vaccines have been widely used in China and also in other 110 countries to date.…”

mentioning

confidence: 91%

Effects of inactivated SARS‐CoV‐2 vaccination on male fertility: A retrospective cohort study

Dong

et al. 2022

Journal of Medical Virology

View full text Add to dashboard Cite

Numerous studies have revealed severe damage to male fertility from severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, raising concerns about the potential adverse impact on reproductive function of the coronavirus disease 2019 (COVID‐19) vaccine developed based on the virus. Interestingly, there are several researchers who have studied the impact of the COVID‐19 mRNA vaccine since then but have come up with conflicting results. As a near‐ideal candidate for mass immunization programs, inactivated SARS‐CoV‐2 vaccine has been widely used in many countries, particularly in less wealthy nations. However, little is known about its effect on male fertility. Here, we conducted a retrospective cohort study at a single large center for reproductive medicine in China between December 2021 and August 2022. Five hundred and nineteen fertile men with no history of laboratory‐confirmed COVID‐19 were included and categorized into four groups based on their vaccination status: unvaccinated group (n = 168), one‐dose vaccinated group (n = 8), fully vaccinated group (n = 183), and booster group (n = 160). All of them underwent a semen analysis and most had serum sex hormone levels tested. There were no significant differences in all semen parameters and sex hormone levels between the unvaccinated group and either vaccinated group. To account for possible vaccination‐to‐test interval‐specific changes, sub‐analyses were performed for two interval groups: ≤90 and >90 days. As expected, most of the semen parameters and sex hormone levels remained unchanged between the control and vaccinated groups. However, participants in vaccinated group (≤90 days) have decreased total sperm motility and increased follicle‐stimulating hormone level compared with the ones in unvaccinated group. Moreover, some trends similar to those found during COVID‐19 infection and recovery were observed in our study. Fortunately, all values are within the normal range. In addition, vaccinated participants reported few adverse reactions. No special medical intervention was required, and no serious adverse reactions happened. Our study suggests that inactivated SARS‐CoV‐2 vaccination does not impair male fertility, possibly due to the low frequency of adverse effects. This information reassures young male population who got this vaccine worldwide, and helps guide future vaccination efforts.

show abstract

mentioning

confidence: 91%

Effects of inactivated SARS‐CoV‐2 vaccination on male fertility: A retrospective cohort study

Dong

et al. 2022

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…The final 12 studies were selected for our systematic review and meta‐analysis (Figure 1 ). 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 …”

Section: Resultsmentioning

confidence: 99%

“…In cases of wrong data in the original article, the corresponding author was further inquired via e‐mail. 10 …”

Section: Methodsmentioning

confidence: 99%

“…In the initial rollout phase after Emergency Use Authorization of BNT162b2 (Pfizer‐BioNTech) and mRNA‐1273 (Moderna), internet search queries also increased significantly for their side effects on fertility potential, indicating public concern and hesitancy for vaccine administration 7 . To date, a number of clinical studies have investigated the impact of different COVID‐19 vaccines on semen quality, while the results have been varied and inconsistent 8–20 …”

Section: Introductionmentioning

confidence: 99%

“… 7 To date, a number of clinical studies have investigated the impact of different COVID‐19 vaccines on semen quality, while the results have been varied and inconsistent. 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of COVID‐19 vaccination on semen parameters: A systematic review and meta‐analysis

Huang

Zheng

Huang

et al. 2022

Journal of Medical Virology

View full text Add to dashboard Cite

The aim of this study was to investigate the effect of coronavirus disease 2019 (COVID‐19) vaccination on semen parameters through systematic review and meta‐analysis. PubMed, EMBASE, Web of Science, and Cochrane Library were comprehensively searched by June 2022. Studies were considered eligible if they compared semen parameters before and after COVID‐19 vaccination or between vaccinated and unvaccinated men, with no restrictions on vaccine types or doses. The effect size was calculated as mean difference (MD) with 95% confidence interval (CI) using a random‐effects model. Subgroup and sensitivity analyses were conducted to assess the sources of heterogeneity measured by the I2 statistic, with publication bias evaluated by Egger's test. Twelve cohort studies involving 914 participants fulfilled the inclusion criteria. In a comparison of vaccinated versus unvaccinated group, the pooled data revealed no significant differences in semen volume (MD = 0.18 ml, 95% CI −0.02 to 0.38), sperm concentration (MD = 1.16 million/ml, 95% CI −1.34 to 3.66), total sperm motility (MD = −0.14%, 95% CI −2.84 to 2.56), progressive sperm motility (MD = −1.06%, 95% CI −2.88 to 0.77), total sperm count (MD = 5.92 million, 95% CI −10.22 to 22.05), total motile sperm count (MD = 2.18 million, 95% CI −1.28 to 5.63), total progressively motile sperm count (MD = −3.87 million, 95% CI −13.16 to 5.43), and sperm morphology (MD = 0.07%, 95% CI −0.84 to 0.97). The results also remained similar across messenger ribonucleic acid, viral‐vector, and inactivated COVID‐19 vaccines. Sensitivity analysis identified two individual studies that contributed to heterogeneity, while the effect size was not materially altered. No obvious publication bias was detected among included studies. Our finding suggested that COVID‐19 vaccination had no detrimental impact on semen quality, which could be potentially helpful to reduce male vaccine hesitancy and increase vaccination coverage.

show abstract

COVID-19 vaccine does not affect male reproductive health (based on RNA-sequencing data)

Adamyan¹,

Вечорко²,

Elagin³

et al. 2021

Probl. reprod.

View full text Add to dashboard Cite

COVID-19 vaccine and male reproductive health (preliminary data)

Cited by 6 publications

References 8 publications

Effects of inactivated SARS‐CoV‐2 vaccination on male fertility: A retrospective cohort study

Effects of inactivated SARS‐CoV‐2 vaccination on male fertility: A retrospective cohort study

Effect of COVID‐19 vaccination on semen parameters: A systematic review and meta‐analysis

COVID-19 vaccine does not affect male reproductive health (based on RNA-sequencing data)

Contact Info

Product

Resources

About