COVID-19 vaccination: science, politics and public health

Wright, Jessica

doi:10.1016/j.adaj.2021.01.009

Cited by 4 publications

(2 citation statements)

References 3 publications

(3 reference statements)

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“…Currently, the most spectacular RNA-backbone biopharmaceuticals are those of already the US FDA approved optimized siRNAs, properly equipped with functional groups, with 2 -OMe modifications among others, allowing them to be efficiently stabilized and delivered, including patisiran (Onpattro ® , 2018) against polyneuropathy (TTR), givosiran (Givlaari ® , 2019) for acute hepatic porphyria (AHP), inclisiran (Leqvio ® , 2020), for the treatment of adults with hypercholesterolemia or mixed dyslipidemia, and lumasiran, sold under the brand name Oxlumo ® (2020), which is a siRNA medication for the treatment of primary hyperoxaluria type 1 (PH1) [10]. The second class of already the US FDA and EU EMA approved RNA biopharmaceuticals are mRNA vaccines that have been developed for use in combating coronavirus disease 2019 (COVID-19 pandemic) [11,12].…”

Section: -O-methylation (-Omementioning

confidence: 99%

First High-Resolution Crystal Structures of DNA:2′-O-Methyl-RNA Heteroduplexes

et al. 2022

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Heteroduplexes composed of all-DNA and all-2′-OMe RNA strands do not occur in nature, but they have found application in the development of molecular beacons and could also be used as aptamers or elements of nucleic acid-based nanostructures that will contain such structural motifs. The crystallization experiments performed have shown that the introduction of overhangs at the ends of the duplex has a great influence on the success of crystallization, as well as on the DNA:2′-OMe-RNA heteroduplex crystal packing. The molecular and crystal structure of the DNA:2′-O-methyl-RNA heteroduplex in its overhanging and blunt-ended versions was determined at 100 K using synchrotron radiation with a resolution of 1.91 and 1.55 Å, respectively. The Zn-SAD method was used to resolve the original duplex structure when molecular replacement by many existing models of duplex structures failed. Both molecules analyzed adopted a conformation close to the A-RNA double helix. The presented structures provide the first insight into this type of heteroduplexes and allowed a comparative analysis with existing nucleic acid homo- and heteroduplex structures. The results of our research expand the knowledge of the structural properties of new heteroduplexes and may be useful for future applications, such as therapies using this class of compounds.

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Section: -O-methylation (-Omementioning

confidence: 99%

First High-Resolution Crystal Structures of DNA:2′-O-Methyl-RNA Heteroduplexes

et al. 2022

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“…Since research has shown that some individuals are more likely to seek dental care (including for cosmetic reasons) compared with medical care, dental professionals need appropriate training so they can counsel their patients appropriately and even administer HPV and other vaccines, including COVID-19 (52). In fact, several states have approved providing vaccines in the dental setting, a view supported by the American Dental Association (53,54).…”

Section: Human Papillomavirus Virus (Hpv) Vaccinementioning

confidence: 99%

A Perspective: Integrating Dental and Medical Research Improves Overall Health

Mouradian

Lee

Wilentz³

et al. 2021

Front. Dent. Med

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The past decade has seen marked increases in research findings identifying oral-systemic links. Yet, much of dental research remains poorly integrated with mainstream biomedical research. The historic separation of dentistry from medicine has led to siloed approaches in education, research and practice, ultimately depriving patients, providers, and policy makers of findings that could benefit overall health and well-being. These omissions amount to lost opportunities for risk assessment, diagnosis, early intervention and prevention of disease, increasing cost and contributing to a fragmented and inefficient healthcare delivery system. This perspective provides examples where fostering interprofessional research collaborations has advanced scientific understanding and yielded clinical benefits. In contrast are examples where failure to include dental research findings has limited progress and led to adverse health outcomes. The impetus to overcome the dental-medical research divide gains further urgency today in light of the coronavirus pandemic where contributions that dental research can make to understanding the pathophysiology of the SARS-CoV-2 virus and in diagnosing and preventing infection are described. Eliminating the research divide will require collaborative and trans-disciplinary research to ensure incorporation of dental research findings in broad areas of biomedical research. Enhanced communication, including interoperable dental/medical electronic health records and educational efforts will be needed so that the public, health care providers, researchers, professional schools, organizations, and policymakers can fully utilize oral health scientific information to meet the overall health needs of the public.

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Using Content Area Reading to Support an Interdisciplinary Storyline Involving Climate Science

Clark,

Jeong

et al. 2024

J. Chem. Educ.

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Addressing the complex and politicized issue of climate change requires innovative educational approaches that transcend traditional disciplinary boundaries. This article describes the development of a collaborative interdisciplinary General Education (GE) course, “Climate Science Chemistry, Education, and Citizenship,″ to merge STEM with non-STEM subjects and address learning objectives that involve personal growth, critical thinking, self-reflection, and informed action. Within a semester-long storyline, the strands of content learning, process, and action are combined and addressed by using content area reading and disciplinary literacy resources. In this Perspective, design considerations of the course are discussed along with educational strategies aiming to cultivate informed, critical, and active citizens ready to tackle the challenges posed by climate change.

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COVID-19 vaccination: science, politics and public health

Cited by 4 publications

References 3 publications

First High-Resolution Crystal Structures of DNA:2′-O-Methyl-RNA Heteroduplexes

First High-Resolution Crystal Structures of DNA:2′-O-Methyl-RNA Heteroduplexes

A Perspective: Integrating Dental and Medical Research Improves Overall Health

Using Content Area Reading to Support an Interdisciplinary Storyline Involving Climate Science

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