COVID-19 Vaccination reduced pneumonia severity

Wada, Noriaki; Li, Yang; Hino, Takuya; Gagne, Staci; Valtchinov, Vladimir I.; Gay, Elizabeth; Nishino, Mizuki; Madore, Bruno; Bond, Sheila A.; Ishigami, Kousei; Hunninghake, Gary M.; Levy, Bruce D.; Kaye, Kenneth M.; Christiani, David C.; Hatabu, Hiroto

doi:10.1016/j.ejro.2022.100456

Cited by 10 publications

(13 citation statements)

References 30 publications

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“…However, we believe that by directly comparing two variant eras as well as using a negative control group, we have mitigated some of these issues. Finally, we did not examine the effect of vaccination in these patients, which may impact pneumonia rate and severity 23 , 24 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Pneumonia Among Patients Who Died with COVID-19 Infection in Ancestral Versus Omicron Variant Eras

et al. 2024

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Section: Discussionmentioning

confidence: 99%

Prevalence of Pneumonia Among Patients Who Died with COVID-19 Infection in Ancestral Versus Omicron Variant Eras

et al. 2024

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“…In recent years, SARS-CoV-2 has also contributed to the pneumonia burden of diseases, although in our study this pathogen had no impact [ 19 ]. However, some studies have suggested that COVID-19 vaccines provide high protection against pneumonia and reduce severity of pneumonia [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Hospitalization for Pneumonia in Italian Adults from 2010 to 2019: Scientific Evidence for a Call to Action

Amodio

Vitale

d’Angela³

et al. 2023

Vaccines

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Background: Understanding trends in pneumonia-associated hospitalizations can help to quantify the burden of disease and identify risk conditions and at-risk populations. This study evaluated characteristics of hospitalizations due to pneumonia that occurred in Italy in a 10-year period from 2010 to 2019. Methods: All hospitalizations with a principal or secondary diagnosis of pneumonia over the 10-year period were included, which were identified by hospital discharges for all-cause pneumonia and pneumococcal pneumonia in the anonymized hospital discharge database of the Italian Health Ministry. Results: A total of 2,481,213 patients were hospitalized for pneumonia between 2010 and 2019; patients aged 75–86 years accounted for 30.1% of hospitalizations. Most hospitalizations (88.1%) had an unspecified pneumonia discharge code. In-hospital death was recorded in 13.0% of cases. The cumulative cost for pneumonia hospitalizations of the 10-year period were EUR 11,303,461,591. Over the observation period, the incidence rate for hospitalized all-cause pneumonia in any ages increased from 100 per 100,000 in 2010 to over 160 cases per 100,000 per year in 2019 (p < 0.001). Overall, there was a significant increase in annual percent changes in hospitalization rates (+3.47 per year), in-hospital death (+4.6% per year), and costs (+3.95% per year) over the 10-year period. Conclusions: Our analysis suggests that hospitalizations for pneumonia are increasing over time in almost all age groups, especially in the elderly. Given the substantial burden of pneumonia in terms of mortality, healthcare resources, and economic costs, greater public health efforts should thus be made to promote vaccinations against influenza and pneumococcus, particularly in high-risk groups.

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“…The Delta variant caused more severe disease and was less susceptible to vaccines than previous lineages [37] (Figure 14). Nevertheless, several studies showed that pneumonia severity was lower in vaccinated than in unvaccinated patients [37,[87][88][89][90][91]96,97]. Lee et al [96] reported that the proportion of patients with negative CT scans was significantly greater in the fully vaccinated group than in the unvaccinated group.…”

Section: Covid-19 Pneumonia After Breakthrough Infectionsmentioning

confidence: 99%

“…Lee et al [96] reported that the proportion of patients with negative CT scans was significantly greater in the fully vaccinated group than in the unvaccinated group. Verma et al [97] reported that the mean CT severity score was significantly lower in completely vaccinated patients in comparison to incom- Nevertheless, several studies showed that pneumonia severity was lower in vaccinated than in unvaccinated patients [37,[87][88][89][90][91]96,97]. Lee et al [96] reported that the proportion of patients with negative CT scans was significantly greater in the fully vaccinated group than in the unvaccinated group.…”

Section: Covid-19 Pneumonia After Breakthrough Infectionsmentioning

confidence: 99%

A Pictorial Essay Describing the CT Imaging Features of COVID-19 Cases throughout the Pandemic with a Special Focus on Lung Manifestations and Extrapulmonary Vascular Abdominal Complications

Brogna

Bignardi

Megliola³

et al. 2023

Biomedicines

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With the Omicron wave, SARS-CoV-2 infections improved, with less lung involvement and few cases of severe manifestations. In this pictorial review, there is a summary of the pathogenesis with particular focus on the interaction of the immune system and gut and lung axis in both pulmonary and extrapulmonary manifestations of COVID-19 and the computed tomography (CT) imaging features of COVID-19 pneumonia from the beginning of the pandemic, describing the typical features of COVID-19 pneumonia following the Delta variant and the atypical features appearing during the Omicron wave. There is also an outline of the typical features of COVID-19 pneumonia in cases of breakthrough infection, including secondary lung complications such as acute respiratory distress disease (ARDS), pneumomediastinum, pneumothorax, and lung pulmonary thromboembolism, which were more frequent during the first waves of the pandemic. Finally, there is a description of vascular extrapulmonary complications, including both ischemic and hemorrhagic abdominal complications.

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COVID-19 Vaccination reduced pneumonia severity

Cited by 10 publications

References 30 publications

Prevalence of Pneumonia Among Patients Who Died with COVID-19 Infection in Ancestral Versus Omicron Variant Eras

Prevalence of Pneumonia Among Patients Who Died with COVID-19 Infection in Ancestral Versus Omicron Variant Eras

Increased Risk of Hospitalization for Pneumonia in Italian Adults from 2010 to 2019: Scientific Evidence for a Call to Action

A Pictorial Essay Describing the CT Imaging Features of COVID-19 Cases throughout the Pandemic with a Special Focus on Lung Manifestations and Extrapulmonary Vascular Abdominal Complications

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