COVID-19 vaccination may enhance hippocampal neurogenesis in adults

Kumar, Ashutosh; Narayan, Ravi Kant; Prasoon, Pranav; Jha, Rakesh Kumar; Kumar, Sujeet; Kumari, Chiman; Pandey, Sada N.; Faiq, Muneeb A.

doi:10.1016/j.bbi.2022.09.020

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…But we try to explain the potential mechanism according to existing research. There is evidence that COVID-19 vaccination may enhance adult hippocampal neurogenesis (AHN), which is the basis for influencing us to establish the concept of learning and memory mechanisms [ 26 , 36 ]. With this enhancement, COVID-19 vaccination can prevent neural degeneration and reduce the occurrence of POD.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, studies proposed that the level of CSF Tau protein, which is a marker of neuronal damage, elevated in patients with COVID-19 [ 37 , 38 ]. The vaccine can increase the level of neurotrophic molecules to reduce the damage of neurons, which may decrease the level of CSF tau protein [ 26 , 38 ]. This is consistent with the negative regulation of tau protein by COVID-19 vaccination in mediation analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The effective rate of vaccination against COVID-19 exceeds 90 % [ 25 ]. Recently, evidence has emerged that COVID-19 vaccination has potential neurotrophic effects and can prevent age-related cognitive decline by enhancing hippocampal neurogenesis (AHN) in adults [ 26 ]. Based on these studies, we propose a hypothesis that COVID-19 vaccination may prevent POD in geriatric patients as a protective factor.…”

Section: Introductionmentioning

confidence: 99%

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COVID-19 vaccination may prevent postoperative delirium in elderly patients undergoing elective non-cardiac surgery: The PNDRFAP and PNDABLE studies

Zhang,

Lin

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

COVID-19 vaccination may prevent postoperative delirium in elderly patients undergoing elective non-cardiac surgery: The PNDRFAP and PNDABLE studies

Zhang,

Lin

et al. 2024

Heliyon

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“…Indeed, it has been suggested that vaccine-induced enhancement of hippocampal neurogenesis may offer protection against age-related cognitive impairment and mental health conditions such as anxiety and depression in adults who have been vaccinated against SARS-CoV-2. 68,69 In addition, among adolescents, early vaccination in uninfected children who are exposed to the virus for the first time may enhance immunity against future variants, suggesting the long-term effectiveness of vaccines. 70 Different types of vaccines are associated with differences in mortality and adverse cardiovascular events.…”

Section: Vaccines Against Sars-cov-2 and Variantsmentioning

confidence: 99%

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 million deaths. Patients with coronavirus disease (COVID‐19) may suffer from diarrhea, sleep disorders, depression, and even cognitive impairment, which is associated with long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients with COVID‐19 have alterations in microbiota and their metabolites, particularly in the gut, which may be involved in the regulation of immune responses. Consumption of probiotics may alleviate the discomfort caused by inflammation and oxidative stress. However, the pathophysiological process underlying the alleviation of COVID‐19‐related symptoms and complications by targeting the microbiota remains unclear. In the current study, we summarize the latest research and evidence on the COVID‐19 pandemic, together with symptoms of SARS‐CoV‐2 and vaccine use, with a focus on the relationship between microbiota alterations and COVID‐19‐related symptoms and vaccine use. This work provides evidence that probiotic‐based interventions may improve COVID‐19 symptoms by regulating gut microbiota and systemic immunity. Probiotics may also be used as adjuvants to improve vaccine efficacy.

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“…Furthermore, GBS appears to occur more frequently in response to immunization with the ChAdOx1 nCoV-19 and Ad26.COV2.S vaccines than with mRNA-based COVID-19 vaccines [ 218 ]. Although the number of reported actual cases of GBS after vaccination with the ChAdOx1 nCoV-19 vaccine is rather low [ 203 , 219 , 220 , 221 , 222 , 223 , 224 ], the quality of sleep might be affected in individuals with post-vaccination GBS due to persistent pain during the night [ 224 ].…”

Section: Covid-19 Vaccines and Premature Psychiatric And Mental Disor...mentioning

confidence: 99%

Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

et al. 2023

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According to the WHO, as of January 2023, more than 850 million cases and over 6.6 million deaths from COVID-19 have been reported worldwide. Currently, the death rate has been reduced due to the decreased pathogenicity of new SARS-CoV-2 variants, but the major factor in the reduced death rates is the administration of more than 12.8 billion vaccine doses globally. While the COVID-19 vaccines are saving lives, serious side effects have been reported after vaccinations for several premature non-communicable diseases (NCDs). However, the reported adverse events are low in number. The scientific community must investigate the entire spectrum of COVID-19-vaccine-induced complications so that necessary safety measures can be taken, and current vaccines can be re-engineered to avoid or minimize their side effects. We describe in depth severe adverse events for premature metabolic, mental, and neurological disorders; cardiovascular, renal, and autoimmune diseases, and reproductive health issues detected after COVID-19 vaccinations and whether these are causal or incidental. In any case, it has become clear that the benefits of vaccinations outweigh the risks by a large margin. However, pre-existing conditions in vaccinated individuals need to be taken into account in the prevention and treatment of adverse events.

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COVID-19 vaccination may enhance hippocampal neurogenesis in adults

Cited by 4 publications

References 11 publications

COVID-19 vaccination may prevent postoperative delirium in elderly patients undergoing elective non-cardiac surgery: The PNDRFAP and PNDABLE studies

COVID-19 vaccination may prevent postoperative delirium in elderly patients undergoing elective non-cardiac surgery: The PNDRFAP and PNDABLE studies

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

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