COVID‐19 vaccination is associated with a decreased risk of orchitis and/or epididymitis in men

Carto, Chase; Nackeeran, Sirpi; Ramasamy, Ranjith

doi:10.1111/and.14281

Cited by 24 publications

(30 citation statements)

References 10 publications

(10 reference statements)

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“…As regards the two studies which detected viral RNA in sperm samples, the international debate has highlighted specific methodological errors made in the two studies [16,72]. In contrast to these studies, comparisons of semen parameters taken before and after men were vaccinated found that corona vaccines had no negative impact on male fertility [74,75,83]. However, male fertility was found to be at least temporarily impaired after SARS-CoV-2 infection, particularly in severe cases of disease, with more than one third of studies showing a deterioration of all 3 relevant semen parameters.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 663 774 men who had received at least one vaccination were compared with 9 985 154 men who were not vaccinated. Orchitis and/or epididymitis occurred significantly less often in men who had been vaccinated (OR = 0.568; 95% CI: 0.497 – 0.649; p < 0.0001) 83 .…”

Section: Corona Vaccinationmentioning

confidence: 93%

“…Bezüglich der beiden Studien mit positivem Virus-RNA-Nachweis im Ejakulat werden international methodische Fehler diskutiert 16 , 72 . Demgegenüber konnte im Vergleich der Spermiogrammparameter vor und nach einer Coronaimpfung kein negativer Einfluss auf die männliche Fertilität durch eine Coronaimpfung nachgewiesen werden 74 , 75 , 83 . Die männliche Fertilität wird hingegen im Falle einer SARS-CoV-2-Infektion, insbesondere bei einem schweren Verlauf, zumindest vorübergehend geschädigt, sodass in mehr als einem Drittel der Studien Einschränkungen in allen 3 relevanten Spermiogrammparametern dargestellt wurden.…”

Section: Fazitunclassified

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Corona and Reproduction, or Why the Corona Vaccination Does Not Result in Infertility

Braun

Feil

Reiser

et al. 2022

Geburtshilfe Frauenheilkd

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Background As the COVID-19 pandemic persists and new vaccines are developed, concerns among the general public are growing that both infection with the SARS-CoV-2 virus and vaccinations against the coronavirus (mRNA vaccines) could lead to infertility or higher miscarriage rates. These fears are voiced particularly often by young adults of reproductive age. This review summarizes the current data on the impact of SARS-CoV-2 infection and corona vaccinations on female and male fertility, based on both animal models and human data. Method A systematic literature search (PubMed, Embase, Web of Science) was carried out using the search terms “COVID 19, SARS-CoV-2, fertility, semen, sperm, oocyte, male fertility, female fertility, infertility”. After the search, original articles published between October 2019 and October 2021 were selected and reviewed. Results Despite the use of very high vaccine doses in animal models, no negative impacts on fertility, the course of pregnancy, or fetal development were detected. In humans, no SARS-CoV-2 RNA was found in the oocytes/follicular fluid of infected women; similarly, no differences with regard to pregnancy rates or percentages of healthy children were found between persons who had recovered from the disease, vaccinated persons, and controls. Vaccination also had no impact on live-birth rates after assisted reproductive treatment. No viral RNA was detected in the semen of the majority of infected or still infectious men; however, a significant deterioration of semen parameters was found during semen analysis, especially after severe viral disease. None of the studies found that corona vaccines had any impact on male fertility. Discussion Neither the animal models nor the human data presented in recent studies provide any indications that fertility decreases after being vaccinated against coronavirus. However, there is a growing body of evidence that severe SARS-CoV-2 infection has a negative impact on male fertility and there is clear evidence of an increased risk of complications among pregnant women with SARS-CoV-2 infection. The counseling offered to young adults should therefore take their fears and concerns seriously as well as providing a structured discussion of the current data.

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Section: Discussionmentioning

confidence: 99%

Section: Corona Vaccinationmentioning

confidence: 93%

Section: Fazitunclassified

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Corona and Reproduction, or Why the Corona Vaccination Does Not Result in Infertility

Braun

Feil

Reiser

et al. 2022

Geburtshilfe Frauenheilkd

View full text Add to dashboard Cite

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“…In a US database study of 663 775 men, Carto et al. revealed that men vaccinated against COVID‐19 had 43.2% decreased odds of being diagnosed with epididymo‐orchitis [ 8 ].…”

mentioning

confidence: 99%

Linking COVID‐19 vaccine and male infertility – not on fertile ground

Katz

2022

BJU International

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“…

We would like to correspond and give our ideas on the publication by Carto et al (2021). Carto et al ( 2021) noted that COVID-19 vaccine recipients, either complete or incomplete all doses, had a decreased risk of getting illness from epididymitis and orchitis after vaccination.

…”

mentioning

confidence: 99%