COVID-19 vaccination in pregnancy: early experience from a single institution

Trostle, Megan E.; Limaye, Meghana; Avtushka, Valeryia; Lighter, Jennifer; Penfield, Christina A.; Roman, Ashley S.

doi:10.1016/j.ajogmf.2021.100464

Cited by 63 publications

(81 citation statements)

References 3 publications

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“…As one of the most frequent complications of early pregnancy is the spontaneous abortion, our study observed that the number of spontaneous abortions during the first trimester in COVID-19-vaccinated pregnant women was not significantly different from the normal incidence in the first trimester in unvaccinated pregnant women, as found in the control group, where pregnancy loss in the first trimester can occur in up to 20% of pregnancies [ 26 ]. In accordance with previously reported data [ 27 ], we noticed no concerning patterns for spontaneous abortions in the first trimester. However, other independent variables such as smoking, abnormal reproductive system anatomy, history of miscarriage, age and existing comorbidities were identified as significant risk factors in this study.…”

Section: Discussionsupporting

confidence: 92%

The Risk of Spontaneous Abortion Does Not Increase Following First Trimester mRNA COVID-19 Vaccination

Citu

Cîtu

Gorun

et al. 2022

JCM

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Clinical trials for COVID-19 vaccines initially excluded pregnant women due to safety concerns, and when the vaccines were authorized for emergency use, they were not recommended for this population. However, observational studies discovered that pregnant women infected with COVID-19 have higher risks of negative pregnancy and delivery outcomes compared to non-pregnant women, raising the question of the risks–benefits of administering COVID-19 vaccines to pregnant women. By mid-2021, there was general consensus on the relative safety of COVID-19 vaccination during pregnancy; therefore, it is critical to investigate the safety issues related to these vaccines, considering the increasing acceptance among pregnant women. To address these concerns, we developed a research project to study the short-term effects and outcomes of COVID-19 vaccination during the first trimester of pregnancy. Our research followed an observational retrospective design for 12 months from the beginning of the vaccination campaign, and included 124 cases of spontaneous abortions and 927 ongoing pregnancies. The odds of spontaneous abortion were non-significant for both versions of the mRNA vaccine (Pfizer BNT162b2 AOR = 1.04, CI = 0.91–1.12; Moderna mRNA-1273 AOR = 1.02, CI = 0.89–1.08). Overall, our data indicated that the risk of spontaneous abortion after mRNA COVID-19 immunization during the first trimester of pregnancy is commensurate with the predicted risk in non-vaccinated pregnant women. These findings contribute to the growing body of information regarding the safety of mRNA COVID-19 vaccination during pregnancy.

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Section: Discussionsupporting

confidence: 92%

The Risk of Spontaneous Abortion Does Not Increase Following First Trimester mRNA COVID-19 Vaccination

Citu

Cîtu

Gorun

et al. 2022

JCM

View full text Add to dashboard Cite

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“…This is a surprising finding. A possible explanation may be found in persistent false messaging on social media that COVID-19 vaccines may cause infertility in females or birth defects [47,48]. Another surprising finding is that the study did not find a statistically significant difference in vaccine booster hesitancy among different racial or ethnic groups, which is contrary to our previous study (unpublished) and other studies [46,49], which showed a significant level of COVID-19 vaccine hesitancy among African Americans and Hispanics.…”

Section: Correlates Of Booster Hesitancycontrasting

confidence: 91%

Assessing Acceptability of COVID-19 Vaccine Booster Dose among Adult Americans: A Cross-Sectional Study

et al. 2021

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Given the emergence of breakthrough infections, new variants, and concerns of waning immunity from the primary COVID-19 vaccines, booster shots emerged as a viable option to shore-up protection against COVID-19. Following the recent authorization of vaccine boosters among vulnerable Americans, this study aims to assess COVID-19 vaccine booster hesitancy and its associated factors in a nationally representative sample. A web-based 48-item psychometric valid survey was used to measure vaccine literacy, vaccine confidence, trust, and general attitudes towards vaccines. Data were analyzed through Chi-square (with a post hoc contingency table analysis) and independent-sample t-/Welch tests. Among 2138 participants, nearly 62% intended to take booster doses and the remaining were COVID-19 vaccine booster hesitant. The vaccine-booster-hesitant group was more likely to be unvaccinated (62.6% vs. 12.9%) and did not intend to have their children vaccinated (86.1% vs. 27.5%) compared to their non-hesitant counterparts. A significantly higher proportion of booster dose hesitant individuals had very little to no trust in the COVID-19 vaccine information given by public health/government agencies (55% vs. 12%) compared to non-hesitant ones. The mean scores of vaccine confidence index and vaccine literacy were lower among the hesitant group compared to the non-hesitant group. Compared to the non-hesitant group, vaccine hesitant participants were single or never married (41.8% vs. 28.7%), less educated, and living in a southern region of the nation (40.9% vs. 33.3%). These findings underscore the need of developing effective communication strategies emphasizing vaccine science in ways that are accessible to individuals with lower levels of education and vaccine literacy to increase vaccination uptake.

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“…Since the launch of the vaccinal campaign against SARS-CoV-2, the issue of pregnant women has been raised by the scientific community and the most important Obstetrics and Gynecology societies released recommendations in favor of it, but on the basis of a free choice of the pregnant woman, given the lack of data. However, reports showed quite soon that the vaccines were able to induce a response in pregnant women [43] , [44] , and that neither obvious safety issues were noticed in pregnant women and their fetuses or newborns [45] , nor a true change in pregnancy complications’ rates [63] . Moreover, the vaccine during pregnancy has been shown to reduce the risk of SARS-CoV-2 infection [64] .…”

Section: Results In the Context Of What Is Knownmentioning

confidence: 99%

Worldwide beliefs among pregnant women on SARS-CoV-2 vaccine: a systematic review

Carbone

Girolamo

Mappa

et al. 2022

European Journal of Obstetrics & Gynecology and Reproductiv

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Background SARS-CoV-2 vaccine has been recommended to pregnant women, but survey studies showed contrasting findings worldwide in relation to the willingness to accept vaccination during pregnancy. Objective To evaluate the evidence from the literature regarding the acceptance rate of the SARS-CoV-2 vaccine in pregnant and breastfeeding women. Study design: We performed a systematic review on the main databases (MEDLINE (PubMed), Scopus, ISI Web of Science) searching for all the peer-reviewed survey studies analyzing the eventual acceptance rate of the SARS-CoV-2 vaccine among pregnant and breastfeeding women. To combine data meta-analyses of proportions and pooled proportions with their 95% confidence intervals (CI) were calculated. Results 15 studies including 25839 women were included in the analysis. The proportion of women actually willing to be vaccinated during pregnancy is 49.1% (95% CI, 42.3-56.0), and the proportion of breastfeeding women is 61.6% (95% CI, 50.0-75.0). Conclusion The cumulative SARS-CoV-2 vaccine acceptance rate among pregnant women appear still low. Vaccinal campaign are urgently needed to drive more confidence into the vaccine to help reducing the spread of the infection and the possible consequences during pregnancy.

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COVID-19 vaccination in pregnancy: early experience from a single institution

Cited by 63 publications

References 3 publications

The Risk of Spontaneous Abortion Does Not Increase Following First Trimester mRNA COVID-19 Vaccination

The Risk of Spontaneous Abortion Does Not Increase Following First Trimester mRNA COVID-19 Vaccination

Assessing Acceptability of COVID-19 Vaccine Booster Dose among Adult Americans: A Cross-Sectional Study

Worldwide beliefs among pregnant women on SARS-CoV-2 vaccine: a systematic review

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