COVID-19 Vaccination in Patients with Cancer

Suzuki, Koyu; Akiyama, Tomohiro; Ueda, Nobuko; Matsumura, Satoko; Mori, Miki; NAMIKI, Masatoshi; Yamada, Norikazu; TSUTSUMI, Chika; TOZAKI, Satoshi; Iwamoto, H; TORII, Shun; Okubo, Yuichiro; Ishiguro, Kiyosuke

doi:10.3390/cancers14102556

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…This survey also confirmed that 80% of the respondents had anxiety or concerns about COVID-19 vaccination. Regarding the timing of COVID-19 vaccination that showed the highest response as a concern in this study and other reports [ 15 ], the Japanese Society of Clinical Oncology recommends the time period when it is better to avoid COVID-19 vaccination [ 8 ]. Considering the latest domestic and international evidence, information regarding vaccination timing is deemed beneficial for endorsing the COVID-19 vaccination.…”

Section: Discussionmentioning

confidence: 89%

Vaccination status, incidence of adverse events, and awareness of COVID-19 vaccine among outpatients undergoing chemotherapy

Iwakawa,

Azechi,

Saigo

et al. 2024

J Pharm Health Care Sci

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Background Cancer has been identified as a risk factor for severe illness and mortality in coronavirus disease (COVID-19), underscoring the importance of recommending COVID-19 vaccinations to patients with cancer. However, few reports have focused on the vaccination status and the incidence of adverse events among patients with cancer. In this study, we aimed to evaluate the vaccination status, incidence of adverse events, concerns, and anxiety related to COVID-19 vaccination among patients with cancer. In addition, we explored the utilization of information sources by these patients and the ease of use. Methods A survey was conducted among outpatients undergoing chemotherapy who received medication counseling from a pharmacist at Juntendo University Hospital. Responses were gathered from 60 out of the 143 participants. Of the respondents, 96.7% had received two doses of the COVID-19 vaccine. Results Common adverse events included pain at the injection site, fever, and fatigue, which were experienced by nearly half of the respondents. Approximately 80% expressed some concern regarding vaccination, with predominant concerns about timing in the context of ongoing cancer treatment and surgery. Among the respondents, 41.7% consulted primary care physicians regarding the vaccine, with only one mentioning consultation with hospital pharmacists. Notably, primary care physicians were considered the most approachable and useful healthcare professionals. Conclusions These results suggest that patients with cancer can safely receive the vaccine, comparable to patients without cancer. However, they still harbor concerns, even when seeking advice from primary care physicians. Few patients consulted pharmacists about vaccination, highlighting an opportunity for pharmacist intervention. Pharmacists fostering trust with patients with cancer is imperative to explore pharmacist intervention methods to promote the continued administration of COVID-19 vaccines and enhance the quality of life for them.

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Section: Discussionmentioning

confidence: 89%

Vaccination status, incidence of adverse events, and awareness of COVID-19 vaccine among outpatients undergoing chemotherapy

Iwakawa,

Azechi,

Saigo

et al. 2024

J Pharm Health Care Sci

View full text Add to dashboard Cite

show abstract

“…Many studies have shown that the administration of COVID‐19 vaccine to patients receiving ICIs may result in an increased risk of irAEs due to the immunogenic effect of vaccination 66,67 . To date, there is insufficient evidence to confirm the correlation between both COVID‐19 vaccine and ICIs.…”

Section: Discussionmentioning

confidence: 99%

Serological response and immune‐related adverse events following COVID‐19 vaccination in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta‐analysis

Wang,

Chen,

Pan

et al. 2023

Reviews in Medical Virology

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With the popularity of Coronavirus disease 2019 (COVID‐19) vaccine and the development of vaccination strategies, the impact of COVID‐19 vaccine on cancer patients receiving immune checkpoint inhibitors (ICIs) is still unclear. In the systematic review and meta‐analysis of patients with ICIs, we assessed the serological response of cancer patients receiving COVID‐19 vaccine, and explored the risk of immune related adverse events (irAEs). We searched PubMed, EMBASE and Cochrane Library as of 10 June 2023, and included cancer patients who received ICIs and COVID‐19 vaccine. The systematic review and meta‐analysis include cohort study, cross‐sectional study and case report. The outcome included the serological response, Spike‐specific T‐cell response, irAEs and rare adverse events. When possible, the data were analysed by random effect analysis, and the statistical heterogeneity was assessed by Q‐test and I2 statistics. We explored the sources of heterogeneity through L’Abbe plots, Galbraith radial plots, and sensitivity analysis. The publication bias was evaluated by Egger's, Begg's linear regression test and funnel plot, and the impact of publication bias was further analysed by trim and fill method. 27 studies were eligible (19 cohort studies, 1 cross‐sectional study and 7 case reports), involving 8331 patients (with 4724 receiving ICIs). Most studies used mRNA vaccine (BNT162b2 or mRNA‐1273). Compared with cancer patients receiving chemotherapy, cancer patients receiving ICIs were significantly more likely to have seroconversion (RR = 1.05, 95%CI 1.01–1.10, P = 0.02). There were no statistically significant differences in seroconversion rates when comparing cancer patients receiving ICIs with controls without cancer (RR = 0.95, 95% CI 0.89–1.01, P = 0.09) or with cancer patients receiving targeted therapy (RR = 1.05, 95% CI 0.79–1.39, P = 0.75). The incidence of irAEs in patients receiving ICIs before and after COVID‐19 vaccination was (21.96%, 95%CI 16.66%–28.94%) and (14.88%, 95%CI 8.65%–25.57%), respectively. The most common irAEs were endocrine abnormalities, skin disorders, etc. The certainty of evidence was low in cancer patients with ICIs, compared with those receiving chemotherapy, and very low versus controls without cancer. Cancer patients treated with ICIs seem to be able to receive COVID‐19 vaccine safely without increasing the incidence of irAEs.

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“…Table 1. Case reports of lymphadenopathy post COVID-19 vaccination from the literature: case 1-6 [31]; case 7 [32]; case 8 [33]. (At https://www.1mdpi.com/ethics10 (accessed on 25 July 2022).…”

Section: Discussionmentioning

confidence: 99%

Lymphedema of the Arm after COVID-19 Vaccination in a Patient with Hidden Breast Cancer and Paraneoplastic Dermatomyositis

et al. 2022

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The pandemic outbreak of Coronavirus Disease 2019 (COVID-19) led to the development of mRNA vaccines. With the extensive vaccination campaign performed worldwide, many adverse reactions to these drugs have been reported in the literature. Although most of them are mild and self-limiting, they may sometimes cause psychological stress and require efforts to make a differential diagnosis with other conditions. This is the case of lymphadenopathies and lymphedema in patients with a history of cancer. Herein we present a case of lymphedema of the arm developed ten days after a VAXZEVRIA COVID-19 vaccine shot in a patient who had concomitant signs and symptoms compatible with a diagnosis of dermatomyositis. It was later classified as paraneoplastic as instrumental investigation revealed a breast carcinoma contralateral to the site of vaccine injection. With this report we ponder an adverse reaction to COVID-19 vaccination with the aim of bringing new data for clinicians who face similar clinical presentations, particularly controversial for radiologists and oncologists.

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COVID-19 Vaccination in Patients with Cancer

Cited by 4 publications

References 28 publications

Vaccination status, incidence of adverse events, and awareness of COVID-19 vaccine among outpatients undergoing chemotherapy

Vaccination status, incidence of adverse events, and awareness of COVID-19 vaccine among outpatients undergoing chemotherapy

Serological response and immune‐related adverse events following COVID‐19 vaccination in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta‐analysis

Lymphedema of the Arm after COVID-19 Vaccination in a Patient with Hidden Breast Cancer and Paraneoplastic Dermatomyositis

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