COVID-19 vaccination in patients receiving dialysis

Wilde, Benjamin; Korth, Johannes; Jahn, Michael; Kribben, Andreas

doi:10.1038/s41581-021-00499-z

Cited by 16 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Infection with this virus can cause severe respiratory failure and death [ 1 ]. Patients undergoing hemodialysis on a regular basis (HD patients) are especially prone to infection with SARS-CoV-2 [ 2 , 3 ], a severe course of the disease, and significantly increased mortality [ 4 , 5 ]. Consequently, HD patients are prioritized to receive vaccines against COVID-19.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Antibody and T Cell Response after a Third Vaccine Dose in Hemodialysis Patients Compared with Healthy Controls

Simon

Rubey

Gromann³

et al. 2022

Vaccines

View full text Add to dashboard Cite

Hemodialysis (HD) patients have an increased risk of severe SARS-CoV-2 infection. In this study, we assess the impact of a third vaccine dose (3D) on antibody levels and T cell response in HD patients and a healthy control group in a prospective cohort study consisting of 60 HD patients and 65 healthy controls. Each participant received two doses of the BNT-162b2 mRNA vaccine and an mRNA vaccine 3D. The SARS-CoV-2 antibody response was measured 6 months after the second vaccine dose and 6 to 8 weeks after the 3D. We assessed INF-γ secretion 6–8 weeks post 3D in 24 healthy controls, 17 HD patients with a normal response, and 20 low responder HD patients. The groups were compared using univariate quantile regressions and multiple analyses. After the 3D, the SARS-CoV-2-specific antibody and INF-γ titers of most HD patients were comparable to those of healthy controls. A subgroup of HD patients who had shown a diminished antibody response after the first two vaccine doses developed a significantly lower antibody and INF-γ response compared to responder HD patients and controls even after the 3D. A new strategy is needed to protect low/non-responder HD patients from severe SARS-CoV-2 infection.

show abstract

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 Antibody and T Cell Response after a Third Vaccine Dose in Hemodialysis Patients Compared with Healthy Controls

Simon

Rubey

Gromann³

et al. 2022

Vaccines

View full text Add to dashboard Cite

show abstract

“…For prevention or reducing the risk of infection with COVID-19, non-pharmacological interventions, like wearing facial masks, keeping social distance, frequent cleaning and applying isolation measures for COVID-19 patients, are effective but challenging to implement in clinical practice [ 6 ]. Thus, COVID-19 vaccines are considered the most promising method to decrease the risk of infection.…”

Section: Introductionmentioning

confidence: 99%

Acceptance of COVID-19 vaccination among maintenance hemodialysis patients: an Egyptian survey study

et al. 2022

View full text Add to dashboard Cite

Background Coronavirus disease 2019 (COVID-19) is a contagious disease that is associated with significant morbidity and mortality especially among maintenance hemodialysis (MHD) patients. COVID-19 vaccination is important to decrease risk and severity of COVID-19 infection. However, vaccine hesitancy is a significant barrier to vaccination. Thus, the aim of this study was to investigate the vaccine acceptability among Egyptian MHD patients. Methods We conducted a paper-based survey on 237 MHD patients in 2 tertiary Egyptian hemodialysis (HD) centers. The survey consisted of a questionnaire that addressed demographic and clinical data, knowledge and attitudes towards COVID-19 infection and vaccines, beliefs regarding both conventional and COVID-19 vaccines, intention of COVID-19 vaccination together with motivators for and barriers against vaccination, sources of information regarding COVID-19 vaccines. Results According to intention to be vaccinated, the patients were divided into vaccine acceptant (VA), hesitant (VH), and resistant (VR) groups who comprised 58.3%, 26.5%, and 15.2%, respectively. Only occupational status and residency were significantly different between the three groups. In 60% of VA group, fear of infection was the main motivator for vaccination. Meanwhile, 40% of VH and VR groups reported that fear of serious side effects of vaccines was the main barrier against vaccination. Television was the primary information source (58.6%) about COVID-19 vaccination while only 18% of patients got their COVID-19 vaccine information from their nephrologists. Conclusions More than half of MHD patients accept to receive COVID-19 vaccine. Vaccine acceptability is not associated with age, gender, educational level, but rather with employment status and residency.

show abstract

“…8 Vaccination is expected to reduce risks of mortality and adverse outcomes in this population, . 9 Such research bolsters numerous ethical arguments supporting vaccine mandates. First, vaccine mandates promote utility, as transplant recipients who are vaccinated are most likely to survive COVID-19, if infected.…”

Section: In Support Of Vaccine Mandates In the Transplant Settingmentioning

confidence: 99%

COVID-19 Vaccine Mandates for Transplant Patients: Caring for Patients Versus Turning Them Away

Ladin

Flescher

Reese

2022

American Journal of Kidney Diseases

View full text Add to dashboard Cite

COVID-19 vaccination in patients receiving dialysis

Cited by 16 publications

References 10 publications

SARS-CoV-2 Antibody and T Cell Response after a Third Vaccine Dose in Hemodialysis Patients Compared with Healthy Controls

SARS-CoV-2 Antibody and T Cell Response after a Third Vaccine Dose in Hemodialysis Patients Compared with Healthy Controls

Acceptance of COVID-19 vaccination among maintenance hemodialysis patients: an Egyptian survey study

COVID-19 Vaccine Mandates for Transplant Patients: Caring for Patients Versus Turning Them Away

Contact Info

Product

Resources

About