COVID-19 Vaccination Improved Psychological Distress (Anxiety and Depression Scores) in Chronic Kidney Disease Patients: A Prospective Study

García-Llana, Helena; Panizo, Nayara; Gandía, Lorena; Orti, Marisa; Giménez-Civera, Elena; Forquet, Claudia; D’Marco, Luis; Puchades, María Jesús; Sargsyan, Mari; Sanchis, Irina; Ribera, Carmen; Marco, Ma Inés; Ferrá, Cristela Moncho; Pérez-Baylach, Carmen María; Bonilla, Begoña; Francés, Francesc Moncho; Pérez-Bernat, Elisa; Sancho, Asunción; Górriz, José Luis

doi:10.3390/vaccines10020299

Cited by 8 publications

(10 citation statements)

References 25 publications

(22 reference statements)

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“…Additionally, the poor health messaging, lockdowns, economic downturn, and poor management of the pandemic in early 2020 were also factors that could be expected to impact depression and anxiety symptoms. A prior study found that COVID-19 vaccination improved anxiety and depression in chronic kidney disease patients ( 9 ). However, in this study, depression and anxiety levels remained high in March 2021, despite the widespread availability of the vaccines that were shown to sharply decrease severe COVID-19, hospitalizations, and death ( 16 ).…”

Section: Discussionmentioning

confidence: 97%

“…However, few studies considered the impact of vaccine availability and whether it helps reduce mental stress. One study on chronic kidney disease patients found that COVID-19 vaccination improved anxiety and depression in this special group of patients ( 9 ). However, there is significant skepticism about COVID-19 vaccine and it is unknown whether the availability of vaccine improved mental health in the general public.…”

Section: Introductionmentioning

confidence: 99%

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The association of COVID-19 vaccine availability with mental health among adults in the United States

et al. 2022

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ObjectiveTo assess whether COVID-19 vaccine approval and availability was associated with reduction in the prevalence of depression and anxiety among adults in the United States.MethodsWe adopted cross sectional and quasi-experimental design with mental health measurements before vaccine availability (June 2020, N = 68,009) and after vaccine availability (March 2021, N = 63,932) using data from Census Pulse Survey. Depression and anxiety were derived from PHQ-2 and GAD-2 questionnaires. We compared rates of depression and anxiety between June 2020 and March 2021. Unadjusted and adjusted analysis with replicate weights were conducted.ResultsDepression prevalence was 25.0% in June 2020 and 24.6% in March 2021; anxiety prevalence was 31.7% in June 2020 and 30.0% in March 2021 in the sample. In adjusted analysis, there were no significant differences in likelihood of depression and anxiety between June 2020 and March 2021.ConclusionDepression and anxiety were not significantly different between June 2020 and March 2021, which suggests that the pandemic effect continues to persist even with widespread availability of vaccines.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The association of COVID-19 vaccine availability with mental health among adults in the United States

et al. 2022

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“…In a study conducted in Spain by Carcia Liana et al, (2022), researchers investigated the impact of COVID-19 vaccination on anxiety and depression scores in patients with CKD. Results showed no significant differences for depression, anxiety, and health-related quality of life scores among the different groups of patients before and after vaccination[ 48 ]. Future studies should address this issue.…”

Section: Discussionmentioning

confidence: 99%

“…It consists two subscales: anxiety subscale (HADS-A) and the depression subscale (HADS-D). The cut-off scores for the total score and subscales are as follows: a) 0–7 normal, b) 8–10 mild/doubtful, and c) >10 moderate-severe (clinical anxiety or depression)[ 25 ]. HADS Greek version has good psychometric properties and has proven useful to clinicians and health professionals for assessing anxiety and depression[ 26 ].…”

Section: Methodsmentioning

confidence: 99%

Risk of sarcopenia, fear of COVID-19, anxiety, depression and physical activity levels: Associations across patients on hemodialysis within Greece

Τσεκούρα¹,

Kalampakos²,

Fousekis³

et al. 2023

JFSF

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Objectives: The purpose of this multicenter cross-sectional study was to investigate the association between SARC-F, fear of COVID 19, anxiety, depression and physical activity in patients undergoing hemodialysis. Methods: This study was conducted in 3 hemodialysis centers in Greece during the period of the COVID-19 pandemic. Sarcopenia risk was assessed using the Greek version of SARC-F (≥4). Demographic and medical history were collected from the patient’s medical charts. The participants were also asked to fill the Fear of COVID-19 Scale (FCV-19S), the Hospital Anxiety and Depression Scale (HADS), and the International Physical Activity Questionnaire (IPAQ) questionnaire. Results: A hundred and thirty-two (132) patients on hemodialysis (92 men, 70.75±13.14 years) were enrolled. Sarcopenia risk (utilizing the SARC-F) was found in 41.7% of patients on hemodialysis. The average duration of hemodialysis was 3.94±4.58 years. The mean score values for SARC-F, FCV-19S and HADS were 3.9±2.57, 21.08±5.32, and 15.02±6.69, respectively. The majority of patients were physically inactive. The SARC-F scores were strongly associated with age (r=56; p<0.001), HADS (r=0.55; p<0.001), levels of physical activity (r=0.5; p<0.001), but not with FCV-19S (r=0.27; p<0.001). Conclusion: A statistically significant relationship was recorded between sarcopenia risk and age, anxiety/depression and levels of physical inactivity in patients on hemodialysis. Future studies are necessary in order to evaluate the association of specific characteristics of patients.

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“…However, in the case of fear of being infected in the pandemic, getting vaccinated may be a psychological resource to reduce anxiety and depression in the population. In a prospective study conducted by Garcia-Llana et al , it was observed that the depression score post-vaccination was significantly lower than the pre-vaccination score among patients with chronic kidney diseases 19. In December 2022, China reopened and moved to a new phase of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Immunosuppressant medication behaviours in solid organ transplant recipients: a cross-sectional study from south-central China during COVID-19 reopening period

Zhao,

Dong,

Wang

et al. 2024

BMJ Open

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ObjectiveMedication non-adherence to immunosuppressants threatens allograft survival and function maintenance among solid organ transplant (SOT) recipients. This study aimed to investigate the prevalence of immunosuppressant medication non-adherence and associated factors during the COVID-19 reopening period among Chinese SOT recipients.DesignCross-sectional study.SettingSouth-central China.PopulationAdult patients who received SOT with functioning graft.MethodsSociodemographic questionnaire and scales to measure physical activity, depression and medication non-adherence were used to collect data. Logistic regression analysis was conducted to identify factors associated with medication non-adherence. Mediation and moderated mediation analyses were performed to examine the potential mechanisms influencing medication behaviour during the pandemic reopening period using SPSS PROCESS macro 4.3 software.ResultsA total of 1121 participants were recruited and the prevalence of medication non-adherence was 36.3% in this study. Recipients who were men, had a higher monthly income, lived alone, had received transplantation for a minimum of 3 years, had received COVID-19 vaccination and experienced depressive symptoms exhibited an increased risk of non-adherence. Contrarily, those who engaged in high-intensity physical activity exhibited a decreased risk. Physical activity was negatively associated with medication non-adherence (r=−0.124, p<0.001) with depression fully mediating this relationship (B=−0.014, 95% CI: −0.032 to –0.003). COVID-19 vaccination significantly moderated the relationship between physical activity and depression (B=−0.303, 95% CI: −0.515 to –0.090).ConclusionThis study investigated the prevalence of medication non-adherence among SOT recipients during the COVID-19 reopening period in China, its associated factors and a potential mechanism. Depression fully mediated the association between physical activity and medication non-adherence, and COVID-19 vaccination moderated the relationship between physical activity and depression. These findings provide some insights for managing medication behaviour when confronting public health emergencies. However, relationships displayed in the moderated mediation model should be tracked after returning to normal life and other potential relationships should be explored to deeply understand medication non-adherent behaviour.

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COVID-19 Vaccination Improved Psychological Distress (Anxiety and Depression Scores) in Chronic Kidney Disease Patients: A Prospective Study

Cited by 8 publications

References 25 publications

The association of COVID-19 vaccine availability with mental health among adults in the United States

The association of COVID-19 vaccine availability with mental health among adults in the United States

Risk of sarcopenia, fear of COVID-19, anxiety, depression and physical activity levels: Associations across patients on hemodialysis within Greece

Immunosuppressant medication behaviours in solid organ transplant recipients: a cross-sectional study from south-central China during COVID-19 reopening period

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