2022
DOI: 10.4330/wjc.v14.i6.343
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COVID-19 vaccination and cardiac dysfunction

Abstract: The coronavirus disease 2019 (COVID-19) mRNA vaccine against severe acute respiratory syndrome coronavirus 2 infections has reduced the number of symptomatic patients globally. A case series of vaccine-related myocarditis or pericarditis has been published with extensive vaccination, most notably in teenagers and young adults. Men seem to be impacted more often, and symptoms commonly occur within 1 wk after immunization. The clinical course is mild in the majority of cases. Based on the evidence, a clinical fr… Show more

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Cited by 3 publications
(2 citation statements)
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“…1,12,13 It is of note that the emergency presentations for vaccine-related chest complaints were equally split between males and females, but abnormal tests and myocarditis had a male predominance, consistent with previous reports. 14,15 Chest pain or discomfort (89%) was the most common presenting symptom, followed by shortness of breath (26.5%) and palpitations (23%), with symptoms broadly similar between those with and without myocarditis. Ng et al 16 described similar symptoms in patients presenting with chest pain postvaccination with or without myocarditis.…”
Section: Discussionmentioning
confidence: 99%
“…1,12,13 It is of note that the emergency presentations for vaccine-related chest complaints were equally split between males and females, but abnormal tests and myocarditis had a male predominance, consistent with previous reports. 14,15 Chest pain or discomfort (89%) was the most common presenting symptom, followed by shortness of breath (26.5%) and palpitations (23%), with symptoms broadly similar between those with and without myocarditis. Ng et al 16 described similar symptoms in patients presenting with chest pain postvaccination with or without myocarditis.…”
Section: Discussionmentioning
confidence: 99%
“…Other systemic side effects, such as fever, headache, myalgia, arthralgia, and fatigue, were also more common among vaccine recipients than control, and younger recipients experienced systemic events more frequently, which may represent an enhanced immune response occurs in young people (Polack et al, 2020). Recently studies have shown that hypersensitivity myocarditis appearance in recipients may be related to the administration of the COVID‐19 mRNA vaccine (Leowattana & Leowattana, 2022; Siripanthong et al, 2020). It is still unknown which parts of the mRNA vaccines are responsible for these adverse events.…”
Section: Current Challenges Of Mrna Vaccinesmentioning
confidence: 99%