COVID-19 vaccination and a severe pain in the neck

Kyriacou, Angelos; Ioakim, Stamatina; Syed, Akheel A.

doi:10.1016/j.ejim.2021.10.008

Cited by 25 publications

(13 citation statements)

References 3 publications

(3 reference statements)

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“…SAT following COVID-19 vaccination has recently been reported [79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96]. Details in these 23 cases and the two present cases are summarized in Table 2.…”

Section: Discussionmentioning

confidence: 88%

Subacute thyroiditis with liver dysfunction following coronavirus disease 2019 (COVID-19) vaccination: report of two cases and a literature review

2022

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Subacute thyroiditis is a transient inflammatory thyroid disease characterized by neck pain, fever, and typical symptoms associated with thyrotoxicosis. The incidence of subacute thyroiditis is higher in female than in male, and susceptibility is prominent in the 30-50-year age range. The variety of case reports on subacute thyroiditis associated with coronavirus disease 2019 (COVID-19) appears to be increasing, and subacute thyroiditis following COVID-19 vaccination has recently been reported. Herein, we report two cases of subacute thyroiditis that developed after receiving the COVID-19 mRNA vaccine, one of which exhibited remarkable liver dysfunction. The mechanism underlying the development of postvaccination subacute thyroiditis remains unknown; however, one theory suggests that adjuvants contained in vaccines may play a role in triggering diverse autoimmune and inflammatory responses. Another possibility is the potential cross-reactivity between the coronavirus spike protein target produced by the mRNA vaccine and thyroid cell antigens. Common side effects of the COVID-19 vaccine include pain at the injection site, fever, fatigue, headache, muscle pain, chills, and nausea. These symptoms are usually resolved within a few days. Subacute thyroiditis may present symptoms similar to those of short-term vaccination side effects or exhibit non-specific symptoms, potentially leading to misdiagnosis or underdiagnosis. Therefore, clinicians should be aware of the possible development of subacute thyroiditis after COVID-19 vaccination.

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Section: Discussionmentioning

confidence: 88%

Subacute thyroiditis with liver dysfunction following coronavirus disease 2019 (COVID-19) vaccination: report of two cases and a literature review

2022

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“…There have been several reports of thyroid dysfunction occurring after SARS-CoV-2 vaccination, with subacute thyroiditis being the most common and neck pain being a common presentation[ 6 ]. The pathophysiology of vaccine-induced thyroid dysfunction is not well understood.…”

Section: Discussionmentioning

confidence: 99%

Thyrotoxicosis in patients with a history of Graves’ disease after SARS-CoV-2 vaccination (adenovirus vector vaccine): Two case reports

Yan¹,

Rong-rong²

2023

World J Clin Cases

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BACKGROUND Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which were approved for emergency use have been administered on a large scale globally to contain the pandemic coronavirus disease 2019 (COVID-19) and to save lives. Vaccine safety is one of the issues under surveillance and a possible correlation between vaccines and thyroid function has been reported. However, reports of the impact of coronavirus vaccines on those with Graves’ disease (GD) are rare. CASE SUMMARY This paper presents two patients with underlying GD in remission, both developed thyrotoxicosis and one developed thyroid storm following the adenovirus-vectored vaccine (Oxford-AstraZeneca, United Kingdom). The objective of this article is to raise awareness regarding a possible association between COVID-19 vaccination and the onset of thyroid dysfunction in patients with underlying GD in remission. CONCLUSION Receiving either the mRNA or an adenovirus-vectored vaccine for SARS-CoV-2 could be safe under effective treatment. Vaccine induced thyroid dysfunction has been reported, but the pathophysiology still not well understood. Further investigation is required to evaluate the possible predisposing factors for developing thyrotoxicosis especially in patients with underlying GD. However, early awareness of thyroid dysfunction following vaccination could avoid a life-threatening event.

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“…Recently, following the massive vaccination programme worldwide, there have been a few reports of thyroid dysfunction after SARS-CoV-2 vaccination, including SAT [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] ] and Graves' disease [ 19 , [29] , [30] , [31] ]. All types of vaccines have been involved, namely inactivated virus SARS-CoV-2 vaccines CORONAVAC [ [13] , [14] , [15] ] and COVAXIN [ 21 ], viral vector-based vaccines VAXZEVRIA [ [16] , [17] , [18] , [19] , [20] , 31 ] and Janssen [ 19 ] and mRNA-based vaccines COMIRNATY [ [22] , [23] , [24] , [25] , [26] , [27] , [28] ] and MODERNA [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, SAT has been described following influenza or hepatitis B vaccination [ [7] , [8] , [9] , [10] , [11] , [12] ]. Recently, cases have been reported of SAT following SARS-CoV-2 vaccination with CoronaVac (Sinovac Life Sciences, China) [ [13] , [14] , [15] ], Vaxzevria (AstraZeneca, Sweden) [ [16] , [17] , [18] , [19] , [20] ], Spikevax (Moderna Biotech, Spain) [ 20 ], Covaxin (Bharat Biotech, India) [ 21 ], and Pfizer-BioNTech SARS-CoV-2 mRNA vaccine (BioNTech, Fosun Pharma, Pfizer, Germany and USA) [ [22] , [23] , [24] , [25] , [26] , [27] , [28] ].…”

Section: Introductionmentioning

confidence: 99%

Recurring subacute thyroiditis after SARS-CoV-2 mRNA vaccine: A case report

Vasileiou

Paschou

Tzamali

et al. 2022

Case Reports in Women's Health

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SARS-CoV-2 vaccination is the most powerful and promising tool against the COVID-19 pandemic. Millions of people have been vaccinated worldwide. Recently, few cases of subacute thyroiditis following SARS-CoV-2 vaccination with various types of vaccine have been reported of subacute thyroiditis following SARS-CoV-2 vaccination with various types of vaccine. We describe here a 36-year-old woman who presented with subacute thyroiditis 10 days after she had received her first dose of the SARS-CoV-2 mRNA vaccine Comirnaty (Pfizer/BioNTech); the condition receded but then recurred 10 days after she received her second dose. As vaccination programmes proceed, clinicians' attention and vigilance for such cases will be increased. Physicians need to know that subacute thyroiditis is a mild and self-limiting condition in the majority of cases. Last but not least, the benefits of vaccination against COVID-19 outweigh the side-effects reported so far.

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COVID-19 vaccination and a severe pain in the neck

Cited by 25 publications

References 3 publications

Subacute thyroiditis with liver dysfunction following coronavirus disease 2019 (COVID-19) vaccination: report of two cases and a literature review

Subacute thyroiditis with liver dysfunction following coronavirus disease 2019 (COVID-19) vaccination: report of two cases and a literature review

Thyrotoxicosis in patients with a history of Graves’ disease after SARS-CoV-2 vaccination (adenovirus vector vaccine): Two case reports

Recurring subacute thyroiditis after SARS-CoV-2 mRNA vaccine: A case report

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