COVID-19 vaccination among Spanish nephrologists: Acceptance and side effects

Abstract

Introduction. Four vaccines against Covid-19 have been approved to date. Their acceptance and safety have not been addressed on healthcare workers. The aim of the present study is to evaluate vaccination rates and side effects among Spanish nephrologists. Methods: All the Spanish nephrologists were invited to participate in this survey. Data on demographics, Covid-19 infection status, received vaccine doses and side effects were collected. Acceptance and side effects were analyzed for Covid-19 vaccination. Factors associated to vaccination were assessed and a multivariate adjusted model was constructed to determine independent predictors for Covid-19 vaccine side effects. Results: A total of 708 nephrologists answered the survey (460 [65%] women, mean age 44±11 years). Six-hundred and eight (86%) had received the first dose and 513 (72%) were fully vaccinated. Most of the subjects (565, 93%) received BNT162b2 (Pfizer-BioNTech®) vaccine. Among vaccinated nephrologists, 453 (75%) presented any side effect; the most frequent was local reaction (68%), followed by myalgia (44%), tiredness (39%) and headache (34%). Age (OR 0.97, 95%CI [0.95-0.99], p<0.0001) and prior Covid-19 infection (OR 2.37, 95%CI [1.27-4.42], p=0.007) were independent predictors for developing side effects with Covid-19 vaccine. Overall side effects were similar with both vaccines, being myalgia (p=0.006) and tiredness (p=0.032) more frequent with the Pfizer-BioNTech® one. Conclusion: Age and prior Covid-19 infection were predictors of vaccination side effects among Spanish nephrologists.

A systematic review on mucocutaneous presentations after COVID‐19 vaccination and expert recommendations about vaccination of important immune‐mediated dermatologic disorders

“… 56 In addition, seven studies reported combined results on more than one vaccine, collectively comprised of 9851 participants. Five of these studies were on BNT162b2 and mRNA‐1273, 72 , 73 , 74 , 75 , 76 one study with the addition of ChAdOx1 nCoV‐19 to the two previous vaccines, 77 and one study with BNT162b2 and ChAdOx1 nCoV‐19. 78 We categorized the studies base on the vaccines administered in Table 4 .…”

“…The most commonly reported comorbidities were hypertension, prior COVID-19, diabetes mellitus, cardiovascular disorders, autoimmune, rheumatologic or allergic disorders, malignancies, obesity, and anaphylaxis. 47,57,59,65,67,[70][71][72][73][74]78,118,[136][137][138][139] In addition, less common co-morbidities including asthma, thyroid disorder, psychological distress, hepatologic disease, and ophthalmologic disease were also mentioned in these studies.…”

Pharmacovigilance of vaccines against COVID-19 in community pharmacies. Results with the first dose

“…El número total de sospechas de RA con la 1ª dosis de las vacunas fue de 1.367, resultando la más prevalente el dolor en el punto de inyección, que afectó al 48 % de los vacunados y supuso un 75,8 % de las RA comunicadas, lo que coincide con otros estudios publicados (17,24,40,43), seguidas de cansancio, fatiga y escalofríos, sobre todo con VZ y JA, lo que ya aparecía en el 11º Informe de FV del Ministerio de Sanidad (44), dolor de cabeza y dolor muscular que aparecen a excepción de los escalofríos, en el mismo orden en el estudio de Amanzio et al (24). En los demás, aun coincidiendo en las RA más prevalentes, el orden difiere en todos ellos (34,(38)(39)(40)43).…”

“…No se observaron diferencias significativas en relación con la condición de fumadores, vivir solo ni haberse contagiado de COVID-19 antes de la vacunación. En este último caso, este hecho sí se considera predictor de la aparición de síntomas tras la vacunación en otros estudios (34,40,43,45).…”

SARS-CoV-2 Infection Evolution Among Nephrologists During the Pandemic: Clinical Features and Impact of Vaccination

“…Spanish nephrologists selfreported reasons for not being vaccinated include lack of appointment, pregnancy, contraindication, or previous COVID-19. 9 Finally, some questions were subjective, such as the appropriate personal protective equipment or the contagion source.…”