COVID-19 Therapy: Could a Copper Derivative of Chlorophyll a Be Used to Treat Lymphopenia Associated With Severe Symptoms of SARS-CoV-2 Infection?

Clark, Nicole F; Taylor‐Robinson, Andrew W.

doi:10.3389/fmed.2021.620175

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…Almost 5,000,000 people have died in this epidemic [46], and the reduction of lymphocytes in COVID-19 patients is considered an important risk factor for poor prognosis [47][48][49]. Recent studies suggest that the chlorophyll derivative sodium copper chlorophyllin (SCC) may improve survival in critically ill COVID-19 patients by increasing the total number of lymphocytes [50]. Increasing consumers choose dietary chlorophyll which is derived from SCC for diet supplements for the sake of keeping healthy [51,52].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis Identifies Biomarkers and Treatment Targets in Primary Sjögren’s Syndrome Patients with Fatigue

Chen

Che

Cai

et al. 2022

BioMed Research International

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We aim to identify the common genes, biological pathways, and treatment targets for primary Sjögren’s syndrome patients with varying degrees of fatigue features. We select datasets about transcriptomic analyses of primary Sjögren’s syndrome (pSS) patients with different degrees of fatigue features and normal controls in peripheral blood. We identify common differentially expressed genes (DEGs) to find shared pathways and treatment targets for pSS patients with fatigue and design a protein-protein interaction (PPI) network by some practical bioinformatic tools. And hub genes are detected based on the PPI network. We perform biological pathway analysis of common genes by Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. Lastly, potential treatment targets for pSS patients with fatigue are found by the Enrichr platform. We discovered that 27 DEGs are identified in pSS patients with fatigue features and the severe fatigued pSS-specific gene is RTP4. DEGs are mainly localized in the mitochondria, endosomes, endoplasmic reticulum, and cytoplasm and are involved in the biological process by which interferon acts on cells and cells defend themselves against viruses. Molecular functions mainly involve the process of RNA synthesis. The DEGs of pSS are involved in the signaling pathways of viruses such as hepatitis C, influenza A, measles, and EBV. Acetohexamide PC3 UP, suloctidil HL60 UP, prenylamine HL60 UP, and chlorophyllin CTD 00000324 are the four most polygenic drug molecules. PSS patients with fatigue features have specific gene regulation, and chlorophyllin may alleviate fatigue symptoms in pSS patients.

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Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis Identifies Biomarkers and Treatment Targets in Primary Sjögren’s Syndrome Patients with Fatigue

Chen

Che

Cai

et al. 2022

BioMed Research International

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“…Moreover, chlorophyll (Chl) may help decrease the risk of developing colon cancer and breast cancer (Pierce et al, 2007;Frugé et al, 2019). Recent research indicated that Chl a derivatives, including sodium copper chlorophyllin, may have beneficial effects on human health when taken at therapeutic doses (Clark and Taylor-Robinson, 2021). Advances in molecular breeding technology and increases in health consciousness have resulted in a growing demand for crops with higher yield, better quality, increased stress resistance, and added health benefits.…”

Section: Discussionmentioning

confidence: 99%

Identification of candidate genes and clarification of the maintenance of the green pericarp of weedy rice grains

Han

Li²,

Qiao³

et al. 2022

Front. Plant Sci.

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The weedy rice (Oryza sativa f. spontanea) pericarp has diverse colors (e.g., purple, red, light-red, and white). However, research on pericarp colors has focused on red and purple, but not green. Unlike many other common weedy rice resources, LM8 has a green pericarp at maturity. In this study, the coloration of the LM8 pericarp was evaluated at the cellular and genetic levels. First, an examination of their ultrastructure indicated that LM8 chloroplasts were normal regarding plastid development and they contained many plastoglobules from the early immature stage to maturity. Analyses of transcriptome profiles and differentially expressed genes revealed that most chlorophyll (Chl) degradation-related genes in LM8 were expressed at lower levels than Chl a/b cycle-related genes in mature pericarps, suggesting that the green LM8 pericarp was associated with inhibited Chl degradation in intact chloroplasts. Second, the F2 generation derived from a cross between LM8 (green pericarp) and SLG (white pericarp) had a pericarp color segregation ratio of 9:3:4 (green:brown:white). The bulked segregant analysis of the F2 populations resulted in the identification of 12 known genes in the chromosome 3 and 4 hotspot regions as candidate genes related to Chl metabolism in the rice pericarp. The RNA-seq and sqRT-PCR assays indicated that the expression of the Chl a/b cycle-related structural gene DVR (encoding divinyl reductase) was sharply up-regulated. Moreover, genes encoding magnesium-chelatase subunit D and the light-harvesting Chl a/b-binding protein were transcriptionally active in the fully ripened dry pericarp. Regarding the ethylene signal transduction pathway, the CTR (encoding an ethylene-responsive protein kinase) and ERF (encoding an ethylene-responsive factor) genes expression profiles were determined. The findings of this study highlight the regulatory roles of Chl biosynthesis- and degradation-related genes influencing Chl accumulation during the maturation of the LM8 pericarp.

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“…Almost 4,200,000 people have died in this epidemic [46], and the reduction of lymphocytes in COVID-19 patients is considered as an important risk factor for poor prognosis [47][48][49]. Recent studies suggest that the chlorophyll derivative sodium copper chlorophyllin (SCC) may improve survival in critically ill COVID-19 patients by increasing the total number of lymphocytes [50]. Increasing consumers choose dietary chlorophyll which is derived from SCC for diet supplements for the sake of keeping healthy [51,52].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Analysis Identifies Biomarkers and Treatment Targets in Primary Sjögren's Syndrome Patients with Fatigue

Chen

Che

Cai

et al. 2021

Preprint

View full text Add to dashboard Cite

We aim to identify the common genes, biological pathways and treatment targets for primary Sjögren's syndrome patients with varying degrees of fatigue features. We select datasets about transcriptomic analyses of Primary Sjögren's syndrome(pSS) patients with different degrees of fatigue features and normal controls in peripheral blood. We identify common differentially expressed genes(DEGs) to find shared pathways and treatment targets for pSS patients with fatigue and design protein-protein interactions (PPIs) network by some practical bioinformatics tools. And hub genes are detected based on the PPIs network. We perform biological pathways analysis of common genes by gene ontology(GO) terms and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway. Lastly, potential treatment targets for pSS patients with fatigue are found by the Enrichr platform. We discovered 27 DEGs are identified in pSS patients with fatigue features and the severe fatigued pSS-specific gene being RTP4. DEGs are mainly localized in the mitochondria, endosomes, endoplasmic reticulum, cytoplasm and are involved in the biological process by which interferon acts on cells and cells defend themselves against viruses. Molecular functions mainly involve the process of RNA synthesis. The DEGs of pSS are involved in the signaling pathways of viruses such as hepatitis C, influenza A, measles, and EBV. Acetohexamide PC3 UP, suloctidil HL60 UP, prenylamine HL60 UP, chlorophyllin CTD 00000324 are the four most polygenic drug molecules. PSS patients with fatigue features have specific gene regulation and chlorophyllin may alleviate fatigue symptoms in pSS patients.

show abstract

COVID-19 Therapy: Could a Copper Derivative of Chlorophyll a Be Used to Treat Lymphopenia Associated With Severe Symptoms of SARS-CoV-2 Infection?

Cited by 7 publications

References 45 publications

Bioinformatic Analysis Identifies Biomarkers and Treatment Targets in Primary Sjögren’s Syndrome Patients with Fatigue

Bioinformatic Analysis Identifies Biomarkers and Treatment Targets in Primary Sjögren’s Syndrome Patients with Fatigue

Identification of candidate genes and clarification of the maintenance of the green pericarp of weedy rice grains

Bioinformatic Analysis Identifies Biomarkers and Treatment Targets in Primary Sjögren's Syndrome Patients with Fatigue

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