COVID 19: The Lack of ACE2 Provides Protection for Children

Abstract

Background In early December 2019, in China the novel severe acute respiratory syndrome coronavirus 2 has been spreading. It was reported that the number of children was lower than adults and they have fewer symptoms. Method Published articles were searched in PubMed, Science direct, in the end 60 articles were collected.Findings Three major findings were found after researching. First, The minority of cases in children category. Secondly, ACE2 resulting penetration in cells after the interaction with virus. And third, a poor presence of ACE2 in lungs children.Discussion Molecularly, the link between the virus and ACE2 was explained, through a segment of viral protein S, comprising four residues nested in RBD. The outbreak due to Sars-Cov-1 has shown that the highest attack rate in China was aged between 20 and 39 (53%).Also, there was a decrease in mortality and severity of diagnosis for patients on ACE inhibitors. It causes a decrease in ACE2 levels. In addition, patients with severe diagnostics are diabetic which lead to the excessive expression of ACE2 in human tissues.Conclusion the ACE2 factor was the aim of our study, but researchers can find many factors linked to the physiology of children.