COVID-19: the efficacy and safety of anticoagulant, glucocorticosteroid therapy and metabolic

Саливончик, Д. П.; Stoma, Igor; Dotsenko, E.A.; Kudenchuk, N.N.; Salivonchyk, E.I.; Khudyakov, I.A.; Menshakova, M.N.; Malasсhenko, E. I.; Salivonchyk, S.D.; Bondareva, K.O.; Степанец, Е.А.; Konovalova, O.V.; Kuhoreva, E.V.

doi:10.33029/2305-3496-2022-11-1-47-56

Cited by 2 publications

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References 3 publications

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“…Ключові слова: робоча сила, соціальна інфраструктура, відтворення робочої сили, життєдіяльність населення, якість робочої сили, духовний і фізичний розвиток. гармонійного розвитку особистості, фізичного здоров'я та добробуту населення [4]. В. Р. Кучеренко та С. М. Макуха аналізують в рамках соціальної інфраструктури села [5].…”

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The Role of Social Infrastructure in Reproducing the Workforce

Fedotova,

Mezentseva

2022

Visnyk DonNUET

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Objective. Determination of the vectors of influence of social infrastructure on the state of the labor sphere and the level of development of the labor potential, development of measures to increase its role in the reproduction of the workforce. Methods. General scientific methods were used as research methods: comparison, analysis and synthesis, generalization, analytical, descriptive, typification, grouping. Results. The concept and role of social infrastructure in the national economy is defined, the author's definition is given. It was determined that the satisfaction of vital needs of the population largely depends on the efficiency of functioning and development of social infrastructure. This makes it possible to improve the quality of life of citizens by ensuring proper conditions for work, recreation, and cultural and educational level. The key goal of the functioning of the social infrastructure is the creation of a complex of life benefits necessary for the expanded reproduction of the labor force. It was established that the social infrastructure is part of the economic complex of each administrative-territorial unit, and therefore is a component of its functional and territorial structures. The functional structure reflects the composition and ratio of groups of objects that perform certain functions in the economic complex, and the territorial structure reflects various forms of spatial concentration of objects and their territorial associations. All elements of social infrastructure are considered from the point of view of their classification according to various characteristics (purpose, sources of formation, location, accessibility for the population, specifics of financing, form of ownership, organizational and legal form). The tasks that the development of social infrastructure is aimed at solving, and the main functions in terms of its influence on the labor sphere, have been established. Two aspects of the development of social infrastructure are indicated: the first shows the effectiveness of using material opportunities to improve the quality of life of the population and reflects the level of socio-economic development of the state, and the second shows the reverse side of the role of social infrastructure in the development of a certain territory from the point of view of providing it with labor resources. The state of development of social infrastructure in Ukraine is assessed.

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The Role of Social Infrastructure in Reproducing the Workforce

Fedotova,

Mezentseva

2022

Visnyk DonNUET

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Predictors of an unfavorable outcome in patients with severe pneumonia against the background of COVID-19 infection

Salivonchyk,

Kurman

2024

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Objective. To determine the predictors of an unfavorable outcome in patients with severe pneumonia against the background of COVID-19 infection.Materials and methods. A retrospective analysis of the case histories of deceased patients (control group, n = 40) for January 2021 (a continuous sample — 15.01.21–31.01.21) and surviving patients for the same period (n = 40) with a confirmed PCR diagnosis of coronavirus infection, who were on inpatient treatment at the state healthcare institution “Gomel City Clinical Hospital No. 3” (SHI “GCCH №3”) in Gomel. The Ethical Committee of SHI “GCCH №3” found no violations contradicting ethics and morality in conducting the study. Treatment of patients, assessment of the severity of the condition were carried out according to modern protocols for the diagnosis and treatment of COVID-19 infection, approved by the Ministry of Health of the Republic of Belarus (No. 1195 of 11.11.2020). The group of surviving patients was represented by 11 men and 29 women versus 24 men and 16 women in the control group (p < 0.05).According to computed tomography of chest organs (CT CO), all 80 patients had signs of bilateral viral pneumonia characteristic of COVID-19. When processing and describing CT data, a semi-quantitative scale was used to estimate the volume of infiltration and consolidation zones of the lungs, recommended by temporary protocols. The total volume of lung damage in COVID-19 infection (“frosted glasses”, “cobblestone pavement”, “consolidation sites”) was > 55% in both groups, p > 0.05. CT CO was performed on Somatom Emotion 6 (Siemens) with a spiral type of scanning.Patients of both groups were comparable in age, concomitant comorbid pathology: coronary heart disease (CHD), arterial hypertension (AH), diabetes mellitus (DM), etc., however, they had differences in gender (the proportion of males prevailed in the group of deceased). A feature of the study was a solid sample among deceased patients. Taking into account the group differences by gender, in this study, an additional comparison of the results by gender was carried out. Results. The course of COVID-19 infection at the stationary stage is characterized by large-scale negative clinical dynamics, fever, “explosion” of acute phase indicators, thrombosis, distress syndrome with a drop in saturation and unfavorable outcomes. The indicators obtained using the NEWS-2, SHOCK-COVID scales (scales for predicting the severity of the clinical course of coronavirus infection) in severe patients, although they indicate a worsening of the patient’s clinical condition, but rather late, when the “cytokine storm”, powerful inflammation, thrombosis, significant damage to lung tissue already dominate among clinical syndromes, the decrease in saturation and the effectiveness of drug therapy is significantly limited.Conclusion. According to the results of the study, it is recommended to divide patients into groups of moderate and high risk of adverse outcome based on clinical, instrumental, laboratory data in dynamics. In patients with moderate risk, protocol therapy in most cases is sufficient to stabilize the general condition. In patients with an unfavorable outcome, this therapy does not restrain the growth of lung tissue damage with negative clinical, laboratory dynamics, which requires additional decisions, changes in the doses of drug therapy to prevent fatal outcomes.

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COVID-19: the efficacy and safety of anticoagulant, glucocorticosteroid therapy and metabolic

Cited by 2 publications

References 3 publications

The Role of Social Infrastructure in Reproducing the Workforce

The Role of Social Infrastructure in Reproducing the Workforce

Predictors of an unfavorable outcome in patients with severe pneumonia against the background of COVID-19 infection

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