COVID‐19 test‐kit trade and trade policy: Implications for developing countries

Vo, Long Hai; Le, Thai‐Ha

doi:10.1111/twec.13276

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…Furthermore, social isolation and travel constraints have led to a decline in routine prenatal visits, resulting in a shift toward delivering neonates at community centers instead of hospitals and subsequent delays in obtaining higher levels of care when needed. The chronic shortage of proper equipment for neonatal resuscitation, which was a problem even before the pandemic,28 may have been exacerbated 32,33…”

Section: Discussionmentioning

confidence: 99%

Qualitative Insights Into Enhancing Neonatal Resuscitation in Post-Pandemic Vietnam

Kain,

Nguyen,

Nguyen

et al. 2024

Advances in Neonatal Care

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Background: The neonatal phase is vital for child survival, with a substantial portion of deaths occurring in the first month. Neonatal mortality rates differ significantly between Vietnam (10.52/1000 live births) and the United States (3.27/1000). In response to these challenges, interventions such as the Helping Babies Breathe (HBB) program have emerged, aiming to enhance the quality of care provided during childbirth, and the postpartum period in low-resource settings. Purpose: The purpose of this study was to explore stakeholder perceptions of the HBB program in Vietnam postpandemic, aiming to identify requisites for resuming training. Methods: Utilizing qualitative content analysis, 19 in-person semistructured interviews were conducted with diverse stakeholders in 2 provinces of Central Vietnam. Results: The content analysis revealed following 5 main themes: (1) the pandemic’s impact on HBB training; (2) resource needs for scaling up HBB training as the pandemic abates; (3) participants’ perceptions of the pandemic’s effect on HBB skills and knowledge; (4) the pandemic’s influence on a skilled neonatal resuscitation workforce; and (5) future prospects and challenges for HBB training in a postpandemic era. Implications for Practice and Research: This research highlights the importance of sustainable post-HBB training competencies, including skill assessment, innovative knowledge retention strategies, community-based initiatives, and evidence-based interventions for improved healthcare decision-making and patient outcomes. Healthcare institutions should prioritize skill assessments, refresher training, and collaborative efforts among hospitals, authorities, non-government organizations, and community organizations for evidence-based education and HBB implementation.

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Section: Discussionmentioning

confidence: 99%

Qualitative Insights Into Enhancing Neonatal Resuscitation in Post-Pandemic Vietnam

Kain,

Nguyen,

Nguyen

et al. 2024

Advances in Neonatal Care

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“…The growth of remote medical testing tools has become pronounced recently and accelerated by the COVID-19 pandemic. The utility of a simple-to-use disposable diagnostic device with colorimetric output was first demonstrated with at-home pregnancy test kits and later refined for devices for the rapid detection of antibodies such as in SARS-CoV-2 variants, which subsequently grew into a US $20 billion industry [ 56 ]. Part of the attractiveness is that the analytes (urine flow and saliva, respectively) are accessible noninvasively and the readouts are simple, being binary in nature.…”

Section: The Role Of Digital Devicesmentioning

confidence: 99%

Toward Personalized Medicine Approaches for Parkinson Disease Using Digital Technologies

Khanna,

Jones

2023

JMIR Form Res

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Parkinson disease (PD) is a complex neurodegenerative disorder that afflicts over 10 million people worldwide, resulting in debilitating motor and cognitive impairment. In the United States alone (with approximately 1 million cases), the economic burden for treating and caring for persons with PD exceeds US $50 billion and myriad therapeutic approaches are under development, including both symptomatic- and disease-modifying agents. The challenges presented in addressing PD are compounded by observations that numerous, statistically distinct patient phenotypes present with a wide variety of motor and nonmotor symptomatic profiles, varying responses to current standard-of-care symptom-alleviating medications (L-DOPA and dopaminergic agonists), and different disease trajectories. The existence of these differing phenotypes highlights the opportunities in personalized approaches to symptom management and disease control. The prodromal period of PD can span across several decades, allowing the potential to leverage the unique array of composite symptoms presented to trigger early interventions. This may be especially beneficial as disease progression in PD (alongside Alzheimer disease and Huntington disease) may be influenced by biological processes such as oxidative stress, offering the potential for individual lifestyle factors to be tailored to delay disease onset. In this viewpoint, we offer potential scenarios where emerging diagnostic and monitoring strategies might be tailored to the individual patient under the tenets of P4 medicine (predict, prevent, personalize, and participate). These approaches may be especially relevant as the causative factors and biochemical pathways responsible for the observed neurodegeneration in patients with PD remain areas of fluid debate. The numerous observational patient cohorts established globally offer an excellent opportunity to test and refine approaches to detect, characterize, control, modify the course, and ultimately stop progression of this debilitating disease. Such approaches may also help development of parallel interventive strategies in other diseases such as Alzheimer disease and Huntington disease, which share common traits and etiologies with PD. In this overview, we highlight near-term opportunities to apply P4 medicine principles for patients with PD and introduce the concept of composite orthogonal patient monitoring.

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“…Furthermore, in emergency contexts, such as thatoccurred in the early COVID-19 pandemic, there may be shortages of reagents, due to their enormous demand, restrictions of transports, and limitations of delivery, hampering their acquisition. This happened all around the world [ 15 ] but specially affected developing countries and areas with less infrastructure adaptation and capacity planning [ 16 ]. Therefore, alternatives were required to surmount supply chain limitations [ 17 , 18 ], as well as the shortage of healthcare professionals [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

A Highly Sensitive Immunoassay for Determination of Immune Response to SARS-CoV-2 in Capillary Blood Samples

et al. 2022

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Throughout the pandemic, serological assays have been revealed as crucial for detecting previous exposures to the virus and determining the timing of antibody maintenance after vaccination or natural infection. This study aimed to develop an optimized enzyme-linked immunosorbent assay (ELISA)-based serology, which could be used in case of reagent shortages, such as that occurred in the beginning of this health emergency. As a result, we present a high-sensitive immunoassay for the determination of IgG levels in venous serum samples, using 2 μg/mL antigen (receptor-binding domain of the spike protein S1) for coating the plate and utilizing human samples at a dilution 1:1000. This method showed non-inferiority features versus a commercial kit, is less expensive, and has a higher spectrophotometric range that allows for a better quantification of the antibody titers. The optical density values before and after heating venous serum samples at 56 °C during 30 min was quite similar, showing that heat inactivation can be used to reduce the biohazardous risks while handling samples. Furthermore, we show that finger-stick capillary blood samples can also serve as a suitable source for IgG detection, bypassing the need for serum isolation and being suitable for point-of-care application (Pearson’s coefficient correlation with capillary serum was 0.95, being statistically significant).

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COVID‐19 test‐kit trade and trade policy: Implications for developing countries

Cited by 6 publications

References 43 publications

Qualitative Insights Into Enhancing Neonatal Resuscitation in Post-Pandemic Vietnam

Qualitative Insights Into Enhancing Neonatal Resuscitation in Post-Pandemic Vietnam

Toward Personalized Medicine Approaches for Parkinson Disease Using Digital Technologies

A Highly Sensitive Immunoassay for Determination of Immune Response to SARS-CoV-2 in Capillary Blood Samples

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