Covid-19: Sore throat, fatigue, and myalgia are more common with new UK variant

Mahase, Elisabeth

doi:10.1136/bmj.n288

Cited by 29 publications

(26 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, one factor that may influence this is the arrival of new variants of SARS-CoV-2 in the Netherlands late in 2020. Early data showed that the Alpha variant might be associated less with loss of smell or taste, and more with cough, muscle ache, and throat ache [29]. But overall, our results show that the association between most individual symptoms and test result did not change much over time, despite the emergence of the Alpha and Delta variants.…”

Section: Plos Onecontrasting

confidence: 54%

“…Unfortunately, we do not know how systematically symptoms were assessed. Lastly, with more research on COVID-19/SARS-CoV-2 infections, our knowledge of the symptoms that are potentially important in identifying new cases of SARS-CoV-2 infection, especially with the spread of new variants, has advanced [28,29]. Some of these symptoms, such as headache, fatigue, or diarrhoea were not included in the list of symptoms used in the Dutch data system.…”

Section: Plos Onementioning

confidence: 99%

See 1 more Smart Citation

Self-reported symptoms as predictors of SARS-CoV-2 infection in the general population living in the Amsterdam region, the Netherlands

et al. 2022

View full text Add to dashboard Cite

Introduction Most COVID-19 symptoms are non-specific and also common in other respiratory infections. We aimed to assess which symptoms are most predictive of a positive test for SARS-CoV-2 in symptomatic people of the general population who were tested. Methods We used anonymised data of all SARS-CoV-2 test results from the Public Health Service of Amsterdam from June 1,2020 through August 31, 2021. Symptoms were self-reported at time of requesting a test. Multivariable logistic regression models with generalized estimating equations were used to identify predictors of a positive test. Included symptoms were: cough, fever, loss of smell or taste, muscle ache, runny nose, shortness of breath, and throat ache; adjustments were made for age and gender, and stratification by month. Results Overall, 12.0% of 773,680 tests in 432,213 unique individuals were positive. All symptoms were significantly associated with a positive test result, the strongest positive associations were: cough (aOR = 1.78, 95%CI = 1.75–1.80), fever (aOR = 2.11, 95%CI = 2.07–2.14), loss of smell or taste (aOR = 2.55, 95%CI = 2.50–2.61), and muscle ache (aOR = 2.38, 95%CI = 2.34–2.43). The adjusted odds ratios for loss of smell or taste slightly declined over time, while that for cough increased. Conclusion Cough, fever, loss of smell or taste, and muscle ache appear to be most strongly associated with a positive SARS-CoV-2 test in symptomatic people of the general population who were tested.

show abstract

Section: Plos Onecontrasting

confidence: 54%

Section: Plos Onementioning

confidence: 99%

Self-reported symptoms as predictors of SARS-CoV-2 infection in the general population living in the Amsterdam region, the Netherlands

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 149 An additional commentary that was based on apparently less reliable data reported an anosmia prevalence for the Alpha variant that differed by less than 4% from that of the G614 virus. 150 , 151 Future studies will be needed for reliable and conclusive data on the phenotypes of these new variants in terms of ACE2 binding affinity, membrane fusion, spike protein shedding, efficiency of host cell entry, viral load in different tissues, transmissibility, infectivity, mortality, and chemosensory dysfunction. Such phenotypes cannot be reliably predicted based on atomic modeling of the receptor binding domain of the spike protein because of the assumptions and restrictions of the modeling parameters.…”

Section: Discussionmentioning

confidence: 99%

The D614G Virus Mutation Enhances Anosmia in COVID-19 Patients: Evidence from a Systematic Review and Meta-analysis of Studies from South Asia

Bartheld

Hagen

Butowt

2021

ACS Chem. Neurosci.

View full text Add to dashboard Cite

The prevalence of chemosensory dysfunction in patients with COVID-19 varies greatly between populations. It is unclear whether such differences are due to factors at the level of the human host, or at the level of the coronavirus, or both. At the host level, the entry proteins which allow virus binding and entry have variants with distinct properties, and the frequency of such variants differs between ethnicities. At the level of the virus, the D614G mutation enhances virus entry to the host cell. Since the two virus strains (D614 and G614) coexisted in the first six months of the pandemic in most populations, it has been difficult to distinguish between contributions of the virus and contributions of the host for anosmia. To answer this question, we conducted a systematic review and meta-analysis of studies in South Asian populations when either the D614 or the G614 virus was dominant. We show that populations infected predominantly with the G614 virus had a much higher prevalence of anosmia (pooled prevalence of 31.8%) compared with the same ethnic populations infected mostly with the D614 virus strain (pooled anosmia prevalence of 5.3%). We conclude that the D614G mutation is a major contributing factor that increases the prevalence of anosmia in COVID-19, and that this enhanced effect on olfaction constitutes a previously unrecognized phenotype of the D614G mutation. The new virus strains that have additional mutations on the background of the D614G mutation can be expected to cause a similarly increased prevalence of chemosensory dysfunctions.

show abstract

“…Graham and colleagues found that individuals infected with the Alpha variant had more variation in their symptoms than previous COVID-19 patients and that loss of taste and smell was less common among patients with the Alpha variant, whereas cough, sore throat, myalgia, and fatigue were more frequent [20,21].…”

Section: B117 Variant (Alpha)mentioning

confidence: 99%

The ins and outs of SARS-CoV-2 variants of concern (VOCs)

et al. 2022

View full text Add to dashboard Cite

SARS-CoV-2, a newly emerging coronavirus that caused the COVID-19 epidemic, has been spreading quickly throughout the world. Despite immunization and some fairly effective therapeutic regimens, SARS-CoV-2 has been ravaging patients, health workers, and the economy. SARS-CoV-2 mutates and evolves to adapt to its host as a result of extreme selection pressure. As a consequence, new SARS-CoV-2 variants have emerged, some of which are classified as variants of concern (VOC) because they exhibit greater transmissibility, cause more-severe disease, are better able to escape immunity, or cause higher mortality than the original Wuhan strain. Here, we introduce these VOCs and review their characteristics, such as transmissibility, immune escape, mortality risk, and diagnostics.

show abstract

Covid-19: Sore throat, fatigue, and myalgia are more common with new UK variant

Abstract: People infected with the new variant of covid-19 discovered in the South East of England (known as B.1.1.7 or VUI 202012/01) are more likely to have a cough, sore throat, fatigue, or myalgia than those infected with other variants, the Office for National Statistics has reported. 1

Cited by 29 publications

References 3 publications

Self-reported symptoms as predictors of SARS-CoV-2 infection in the general population living in the Amsterdam region, the Netherlands

Self-reported symptoms as predictors of SARS-CoV-2 infection in the general population living in the Amsterdam region, the Netherlands

The D614G Virus Mutation Enhances Anosmia in COVID-19 Patients: Evidence from a Systematic Review and Meta-analysis of Studies from South Asia

The ins and outs of SARS-CoV-2 variants of concern (VOCs)

Contact Info

Product

Resources

About