We examined the role of family support in influencing attitudes about social distancing and positive mental health during the COVID-19 pandemic among 1547 Chinese people. The results showed that after the effects of demographic variables were controlled, perceived support from family members made unique contributions to their attitudes about social distancing and positive mental health both directly and indirectly (via buffering loneliness). These results suggest that strong support from family plays an important role in improving individuals’ attitudes about social distancing and maintaining positive mental health during the epidemic.