COVID-19: semen impairment may not be related to the virus

Bendayan, Marion; Boitrelle, Florence

doi:10.1093/humrep/deab082

Cited by 10 publications

(9 citation statements)

References 9 publications

(3 reference statements)

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“…The viral load may directly induce the testicular damage 24 or indirectly through the immune response, either innate or adaptive, activated to fight against the virus 25 . In addition, the testicular damage can be due to the high local temperatures reached during viral dissemination 26,27 …”

Section: Discussionmentioning

confidence: 99%

Male reproductive system inflammation after healing from coronavirus disease 2019

et al. 2021

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Background: There is evidence that, after severe acute respiratory syndrome coronavirus 2 infection, male reproductive function and semen quality may be damaged Objectives: To evaluate a panel of inflammatory mediators in semen in patients recovered from coronavirus disease 2019. Material and methods:Sexually active men with previous severe acute respiratory syndrome coronavirus 2 infection and proven recovery from coronavirus disease 2019 were enrolled in a prospective cohort study. Clinical, uro-andrological data and semen specimens were prospectively collected. For previously hospitalized coronavirus disease 2019 patients, data on serum inflammatory markers were retrospectively collected.Results: A total of 43 men were enrolled in the study. Of these, 32 men were normozoospermic, three were oligozoospermic, and eight were crypto-azoospermic. Serum inflammatory markers (procalcitonin and C-reactive protein) were analyzed in previously hospitalized patients both at admission and at peak of infection. Levels at admission were statistically significantly higher in patients resulting in crypto-azoospermic with respect to those resulting in normozoospermic (p = 0.05; p = 0.03 and p = 0.02,

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Section: Discussionmentioning

confidence: 99%

Male reproductive system inflammation after healing from coronavirus disease 2019

et al. 2021

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“…Biases are also attributable to the nature of the studies, the lack of controls (negative patients or baseline seminal characteristics according to the studies' designs), and possible confounding factors, such as baseline heterogeneity of participants' characteristics (i.e., age, comorbidity, lifestyle) and time of sperm specimen collection [244]. Other hypotheses may be considered for explaining the results, especially in interpreting quantitative and qualitative sperm changes, including the effect of fever and considering the severity of clinical presentations (semen collection was usually carried out within 3 months since the diagnosis of SARS-CoV-2 infections), medications assumed for treating COVID-19 (i.e., antibiotics, corticosteroids), and sexual abstinence [245].…”

Section: Gonadsmentioning

confidence: 99%

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Lisco

Tullio

Stragapede

et al. 2021

JCM

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: Background and aim. The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19). Methods. Scientific and institutional websites and databases were searched and data were collected and organized, when plausible, to angle the discussion toward the following clinical issues. (1) Are patients with COVID-19 at higher risk of developing acute or late-onset endocrine diseases or dysfunction? (2) May the underlying endocrine diseases or dysfunctions be considered risk factors for poor prognosis once the infection has occurred? (3) Are there defined strategies to manage endocrine diseases despite pandemic-related constraints? Herein, the authors considered only relevant and more frequently observed endocrine diseases and disorders related to the hypothalamic-pituitary region, thyroid and parathyroid glands, calcium-phosphorus homeostasis and osteoporosis, adrenal glands, and gonads. Main. Data highlight the basis of some pathophysiological mechanisms and anatomical alterations of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced endocrine dysfunctions. Some conditions, such as adrenal insufficiency and cortisol excess, may be risk factors of worse clinical progression once the infection has occurred. These at-risk populations may require adequate education to avoid the SARS-CoV-2 infection and adequately manage medical therapy during the pandemic, even in emergencies. Endocrine disease management underwent a palpable restraint, especially procedures requiring obligate access to healthcare facilities for diagnostic and therapeutic purposes. Strategies of clinical triage to prioritize medical consultations, laboratory, instrumental evaluations, and digital telehealth solutions should be implemented to better deal with this probably long-term situation.

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“…94 It still remains unclear whether the impact on spermatogenesis is specific to SARS-CoV-2 or whether the fever associated with COVID-19 (80% of cases) could highly contribute to the observed alterations. 99,100 Overall, the impact of viral infections on semen parameters is still being debated, due to the existence of biases such as an associated fever 101,102 or antiviral therapy toxicity. 71,81,82 Most of the studies investigating the effect of viral infections on male fertility focus mainly on sperm motility and it would be necessary to evaluate more specifically their consequences on sperm vitality.…”

Section: Covid-19mentioning

confidence: 99%

Necrozoospermia: The tree that hides the forest

et al. 2022

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Background: Necrozoospermia is a condition found in 0.2%-0.4% of male infertility cases. The causes of necrozoospermia are multiple: they can be related to testicular and/or post-testicular damage. Additionally, these causes most often involve the production of reactive oxygen species (ROS) and/or sperm DNA fragmentation (SDF) which can reduce the chances of spontaneous pregnancy or affect the outcome of assisted reproductive technologies.Objective: To focus on potential etiologies of necrozoospermia, its diagnosis and its therapeutic management especially before the employment of ICSI.Methods: Authors searched PubMed/Medline, Web of Science, Cochrane Library, Google and Institutional websites for medical subheading terms and free text words referred to "necrozoospermia", "sperm vitality", "sperm viability", SDF and "ICSI". Results:We identified 12 main etiologies of necrozoospermia responsible for either a decrease of sperm vitality, a mild, a moderate or a severe necrozoospermia. In case of a confirmed decreased vitality, a thorough check-up should be conducted and if available, etiological treatment should be proposed. Therapeutic management could also include repeated ejaculations, drug treatments, the use of ICSI with ejaculated or surgically extracted spermatozoa in case of a non-treatable necrozoospermia. Discussion and conclusion:The potential causes of necrozoospermia should be investigated because many of them could be corrected, thus avoiding the use of ICSI. Moreover, if ICSI procedure remains necessary, the therapeutic management of necrozoospermia could also improve the chances of success by reducing oxidative stress and/or SDF.

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COVID-19: semen impairment may not be related to the virus

Cited by 10 publications

References 9 publications

Male reproductive system inflammation after healing from coronavirus disease 2019

Male reproductive system inflammation after healing from coronavirus disease 2019

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Necrozoospermia: The tree that hides the forest

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