COVID-19 presented with syndrome of inappropriate ADH secretion(SIADH): A case report from Bangladesh

Chowdhury, Reaz Uddin; Akter, Kazi Shanzida; Moula, Mohammad Moksedul; Kabir, Muhammad Anwarul; Bhuiyan, Sahedul Islam; Das, Bimal Chandra

doi:10.1016/j.rmcr.2020.101290

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…Currently, a few case reports and a small series of cases with concomitant severe COVID-19 pneumonia were reported [80][81][82][83][84]. Ho et al reported the first case of COVID-19 associated with SIADH and new-onset seizures [82], whereas Yousaf et al published a series of three cases of patients diagnosed with COVID-19 with severe acute hyponatremia due to SIADH [80].…”

Section: Hyponatremia-syndrome Of Inappropriate Antidiuretic Hormone Secretion (Siadh)mentioning

confidence: 99%

COVID-19 and the pituitary

et al. 2021

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Background Despite COVID-19 being identified as severe respiratory viral infection, progressively many relevant endocrine manifestations have been reported greatly contributing to the severity of the clinical presentation. Systemic involvement in COVID-19 is due to the ubiquitous expression of angiotensin-converting enzyme 2 (ACE2) receptor, responsible for the entry in the cells of SARS-CoV-2, Several reports in humans and animal models showed a significant ACE2 mRNA expression in hypothalamus and pituitary cells. Moreover, higher mortality and poorer outcomes have been widely described in COVID-19 patients with obesity, diabetes and vertebral fractures, which are all highly prevalent in subjects with pituitary dysfunctions. Aim To review the main endocrine manifestations of COVID-19 with their possible implications for pituitary diseases, the possible direct and indirect involvement of the pituitary gland in COVID-19, the impact of COVID-19 on the management of established pituitary diseases which can be already at increased risk for worse outcomes and on neurosurgical activities as well as vaccination. Conclusions Our review underlines that there could be a specific involvement of the pituitary gland which fits into a progressively shaping endocrine phenotype of COVID-19. Moreover, the care for pituitary diseases need to continue despite the restrictions due to the emergency. Several pituitary diseases, such as hypopituitarism and Cushing disease, or due to frequent comorbidities such as diabetes may be a risk factor for severe COVID-19 in affected patients. There is the urgent need to collect in international multicentric efforts data on all these aspects of the pituitary involvement in the pandemic in order to issue evidence driven recommendations for the management of pituitary patients in the persistent COVID-19 emergency.

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Section: Hyponatremia-syndrome Of Inappropriate Antidiuretic Hormone Secretion (Siadh)mentioning

confidence: 99%

COVID-19 and the pituitary

et al. 2021

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“…Hyponatremia has been described to be a common occurrence in various lung diseases and is associated with adverse outcome of patients [ 12 ]. Hyponatremia in the context of SIADH has also been linked to several conditions of the lungs including COVID-19 [ 1 – 3 ]. During the last months vaccination programs against COVID-19 started internationally, administering immunizations to an increasing number of people.…”

Section: Discussionmentioning

confidence: 99%

“…SIADH has been described to be associated with a multitude of conditions and medications with diseases of the lung being quite prominent [ 1 ]. Only recently, SIADH was also described in patients infected with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) [ 2 , 3 ]. To this date, intensive vaccination programs have started world-wide in order to fight the pandemic [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The syndrome of inappropriate antidiuresis after vaccination against COVID-19: case report

Lindner

Ryser

2021

BMC Infect Dis

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Background The Syndrome of Inappropriate Antidiuresis (SIADH) has been described to be associated with a multitude of conditions and medications, including the severe acute respiratory syndrome coronavirus 2. We describe the case of a patient with newly diagnosed and symptomatic SIADH after receiving the second COVID-19 vaccination not explained otherwise. Case presentation A 79-year-old male person was admitted to the emergency department due to a worsening of his general health state expressed by weakness, fatigue and anorexia. Vital signs and clinical findings were normal, in particular the patient was considered to be euvolemic. Laboratory investigations revealed a serum sodium of 117 mmol/L, a serum osmolality of 241 mosm/kg and a urea of 1.2 mmol/L with creatinine within normal range. Urine chemistry showed a urine osmolality of 412 mosm/kg and urine sodium of 110 mmol/L. TSH, C-reactive protein, and basal cortisol levels were normal. Under therapy with balanced crystalloid fluids, hyponatremia worsened and in absence of diuretic medications, diagnosis of SIADH was made. Since fluid restriction was not sufficiently effective, oral urea was administered. Under this therapy regimen hyponatremia resolved. Conclusions Local as well as systemic reactions have been described for the new mRNA-based vaccines including pain and fever. Therefore, it is imaginable that the vaccine might trigger SIADH in some patients.

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“…Literature bakıldığında bizim olgumuza benzer olgular bildirilmiştir. Bu olguların özellikleri Tablo 1'de gösterilmiştir ve olguların hepsinin COVID-19 PCR sonucu pozitiftir [12][13][14][15]. COVID-19 pnömonisinin yaptığı UADHSS'nin patofizyolojisinde belirgin proinflamatuar sitokinlerin, özellikle IL-6 düzeyinin etkin olduğu rapor edilmiştir.…”

Section: Discussionunclassified

Covıd-19 pnomonisi ile ilişkili uygunsuz antidiüretik hormon salınım sendromu olgusu

Akgül¹,

Atabey²,

Zileligil³

2021

Pamukkale Medical Journal

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Başlık: Covıd-19 pnömonisi ile ilişkili uygunsuz antidiüretik hormon salınımı sendromu olgusu. Kısa başlık: Covıd-19 ve uygunsuz antidiüretik hormon salınımı sendromu olgusu. Öz: Uygunsuz antidiüretik hormon salınımı sendromu (UADHSS), hastanede yatan hastalarda hiponatreminin en sık nedenlerinden biridir. Hiponatreminin etiyolojisinde birçok neden olmasından dolayı sebebinin bulunup ve tedavi edilmesinde güçlük yaşanabilmektedir. UADHSS'ye neden olabilecek birçok infeksiyon hastalığı bildirilmiştir. Bununla birlikte Koronavirüs 2019 hastalığı (COVID-19) ile ilişkili hiponatremi ve UADHSS son zamanlarda birkaç olgu raporunda belirtilmiştir. Bizim olgumuzda ise ilk hastaneye başvuru sırasında COVID-19 pnömonisinin klasik semptomları olan öksürük, nefes darlığı ve ateş şikayeti, ikinci başvurusunda ise hiponatreminin klinik semptomlarından olan halsizlik, genel durum bozukluğu görülmekteydi. COVID-19 olan hastamızda hiponatremi ve UADHSS'nın görülebileceğini vurgulamayı amaçladık.

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COVID-19 presented with syndrome of inappropriate ADH secretion(SIADH): A case report from Bangladesh

Cited by 9 publications

References 13 publications

COVID-19 and the pituitary

COVID-19 and the pituitary

The syndrome of inappropriate antidiuresis after vaccination against COVID-19: case report

Covıd-19 pnomonisi ile ilişkili uygunsuz antidiüretik hormon salınım sendromu olgusu

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