COVID-19 : physiopathologie d’une maladie à plusieurs visages

Bonny, Vincent; Maillard, Alexis; Mousseaux, Cyril; Plaçais, Léo; Richier, Quentin

doi:10.1016/j.revmed.2020.05.003

Cited by 38 publications

(33 citation statements)

References 194 publications

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“…Diabetes is an independent predictor of morbidity and mortality in COVID-19 (8,9). Regardless of the time of discovery, it predisposes to severe forms through its susceptibility to infection.…”

Section: Association Between Total Baseline Cortisol and Clinical Feamentioning

confidence: 99%

Baseline Serum Total Cortisol During the Primary Corona Virus Infection in the Beginning of the Pandemic in Cameroon

Etoga¹,

Inna²,

Guewo-Fokeng³

et al. 2020

Preprint

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Introduction: Improvement of critically ill patients Covid 19 positive placed on glucocorticoids may suggest impairment of the adrenal function. Our objective was to evaluate baseline serum cortisol in covid+ patients.Methods: This was a descriptive and analytical cross-sectional study conducted in a population of patients infected with 2019-nCoV in Cameroon. Patients receiving corticosteroids irrespective of the route of administration within 3 months prior to recruitment and those with any hypothalamic-pituitary-adrenal axis disease were excluded. We reviewed the medical records of patients to collect socio-demographic and clinical data. Patients were then sampled at 8 am for serum cortisol assay by the competitive ELISA method. Statistical analyses were performed using the Student's test to compare means. The significance level was set at p<0.05. Results: We included 80 covid+ patients, predominantly males (45, 56.3%) with a mean age of 43±13 years. The co-morbidities found were hypertension (9, 11.3%), diabetes mellitus (7, 8.8%), cardiovascular disease (8, 10%) and obesity (4, 5%). The most common symptoms were asthenia (44, 55%), fever (36, 45%) and respiratory symptoms (75, 93.7%). The non-severe form was the most common (70, 87.5%). Only 12.5% (10) of patients received oxygen therapy within our study. The mean baseline serum cortisol in the series was 279.55 nmol/l±128.68 (min 96.1332 nmol/l; max 665.0521 nmol/l). Sixty-nine patients (86.3%) had baseline cortisol ≤413.79nmol/l, suggesting an insufficient response to stress. No statistically significant association was found between serum cortisol and disease severity.Conclusion: The absence of a marked rise of cortisol during COVID-19 suggests possible involvement of the hypothalamic-pituitary-adrenal axis in this infection.

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Section: Association Between Total Baseline Cortisol and Clinical Feamentioning

confidence: 99%

Baseline Serum Total Cortisol During the Primary Corona Virus Infection in the Beginning of the Pandemic in Cameroon

Etoga¹,

Inna²,

Guewo-Fokeng³

et al. 2020

Preprint

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“…Se trata de virus con una cadena única de ARN envuelta por una cápside, de morfología variable (habitualmente redondeado u ovoideo) y con un tamaño que oscila entre 60 y 140 nm 11 . La nucleocápside está protegida por una envuelta fosfolipídica en la que se insertan las glucoproteínas de superficie (S, HE, M y E) 12 . De ellas, tiene especial relevancia la proteína S, que es la que se une al receptor celular para permitir la entrada del virus a la célula 13 .…”

Section: La Infección Covid-19 Lo Que El Radiólogo Debería Saberunclassified

“…La fisiopatología básica de la infección COVID-19 se presenta en las Figura 1 , Figura 2 , Figura 3 . Estas figuras son adaptaciones de las teorías publicadas en las referencias 12 , 16 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 . Para profundizar en la fisiopatología se recomienda revisar dichas referencias.…”

Section: La Infección Covid-19 Lo Que El Radiólogo Debería Saberunclassified

Gestión de la pandemia. Visión del radiólogo

et al. 2020

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La infección COVID-19 está obligando a toda la sociedad a adoptar numerosos cambios, al menos hasta que existan un tratamiento o vacuna eficaces. El impacto que está produciendo en nuestro sistema sanitario tiene pocos precedentes similares, al tratarse de una patología nueva y que ha obligado a tomar decisiones complejas a partir de una evidencia escasa. Los servicios de radiología tienen un papel fundamental en el manejo de esta patología, tanto en el diagnóstico como en el manejo posterior de los pacientes. Pero, para ello, se debe entender la infección, de forma que se puedan poner en marcha circuitos seguros para pacientes y trabajadores. En este artículo se resume la fisiopatología de la infección COVID-19 y se presentan las medidas que se deben adoptar en el servicio de radiología.

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“… 11 The nucleocapsid is protected by a phospholipid envelope into which the surface glycoproteins are inserted (S, HE, M and E). 12 Of the these, the S protein is particularly relevant, as it binds to the cell receptor to allow the virus to enter the cell. 13 The S protein is divided functionally into two domains: S1 (responsible for binding with the cell receptor) and S2 (which permits fusion with the cell membrane).…”

Section: Introductionmentioning

confidence: 99%

“…These figures are adaptations of the series published in references. 12 , 16 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 These references should be reviewed in order to further explore the pathophysiology. In summary, the main points that must be considered in order to understand the pathogenesis, radiological manifestations and treatment possibilities are the following: The virus activates inflammatory and immune response in the lungs, with the production of cytokines and interferon and activation of lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Managing the pandemic from the radiology department’s point of view

Valdés

Guerrero

Morales

et al. 2020

Radiología (English Edition)

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The COVID-19 pandemic is forcing our entire society to adopt numerous changes, at least until an effective treatment and/or vaccine becomes widely available. Because COVID-19 is a new disease that has required us to make complex decisions based on scant evidence, the pandemic is having an enormous impact on our health system. Radiology departments play a fundamental role in the management of COVID-19, both in the diagnosis of the disease and in the posterior management of patients. To ensure the safety of patients and healthcare professionals, it is essential to understand the infection so that safe circuits can be implemented. This article summarizes the pathophysiology of COVID-19 infection and explains the measures that radiology departments need to adopt during the pandemic.

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COVID-19 : physiopathologie d’une maladie à plusieurs visages

Cited by 38 publications

References 194 publications

Baseline Serum Total Cortisol During the Primary Corona Virus Infection in the Beginning of the Pandemic in Cameroon

Baseline Serum Total Cortisol During the Primary Corona Virus Infection in the Beginning of the Pandemic in Cameroon

Gestión de la pandemia. Visión del radiólogo

Managing the pandemic from the radiology department’s point of view

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