COVID-19 Outcomes Amongst Patients With Pre-existing Cardiovascular Disease and Hypertension

Chakinala, Raja Chandra; Shah, Chail; Rakholiya, Jigisha; Martin, Mehwish; Kaur, Nirmaljot; Singh, Harmandeep; Okafor, Toochukwu L; Nwodika, Chika; Raval, Payu; Yousuf, Salma; Lakhani, Komal; Yogarajah, Angelina; Malik, Preeti; Singh, Jagmeet; Kichloo, Asim; Patel, Urvish

doi:10.7759/cureus.13420

Cited by 10 publications

(11 citation statements)

References 23 publications

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“…Similar to previous studies ( Chakinala et al, 2021 , Dalekos et al, 2021 , Emami et al, 2020 , Jordan et al, 2020 , Kyriazopoulou et al, 2021 , Li et al, 2021 , Rydyznski Moderbacher et al, 2020 ) , we demonstrated that older age and underlying comorbidities - including severe obesity, chronic heart and respiratory disease and additional chronic disorders - significantly affected the phenotype of SARS-CoV-2 infection. Furthermore, we observed that patients carrying the B allele (rs1800450) of the MBL2 gene also displayed worsened clinical presentation, as these patients more frequently required hospitalization because of pneumonia necessitating supplemental oxygen administration.…”

Section: Discussionsupporting

confidence: 91%

MBL deficiency-causing B allele (rs1800450) as a risk factor for severe COVID-19

et al. 2021

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The COVID-19 pandemic represents one of the greatest challenges in modern medicine. The disease is characterized by a variable clinical phenotype, ranging from asymptomatic carriage to severe and/or critical disease, which bears poor prognosis and outcome because of the development of severe acute respiratory distress syndrome (SARS) requiring ICU hospitalization, multi-organ failure and death. Therefore, the determination of risk factors predisposing to disease phenotype is of outmost importance. The aim of our study was to evaluate which predisposing factors, including MBL2 genotyping, affected clinical phenotype in 264 COVID-19 patients. We demonstrated that older age along with underlying comorbidities, primarily obesity, chronic inflammatory disorders and diabetes mellitus, represent the most important risk factors related to hospitalization, the development of pneumonia and SARS. Moreover, we found that the presence of the MBL deficiency-causing B allele (rs1800450) was significantly associated with almost 2-fold increased risk for developing pneumonia and requiring hospitalization , suggesting its usage as a molecular predictor of severe disease in SARS-CoV-2 infected individuals.

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Section: Discussionsupporting

confidence: 91%

MBL deficiency-causing B allele (rs1800450) as a risk factor for severe COVID-19

et al. 2021

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“…A recent meta-analysis of 29,750 patients identified that the prevalence of HTN and cardiovascular disease (CVD) in SARS-CoV-2 patients was 32.7% and 18.2%, respectively. Although this study reported that neither pre-existing HTN nor CVD was associated with greater mortality, they did report that CVD was associated with greater levels of invasive mechanical ventilation [58]. In contrast, earlier studies have reported that poor outcomes are significantly greater for HTN and CVD patients suffering from SARS-CoV-2 [59], with one suggesting the case-fatality rate to be double for HTN and over triple for CVD [60].…”

Section: Hypertension and Cardiovascular Morbiditymentioning

confidence: 61%

“…The mechanisms underlying disease severity in cases with HTN and CVD are not entirely clear. It is suggested that underlying CVD can be exacerbated by myocyte damage caused by hypoxia, in addition to the cytokine storm discussed above [58]. Further to this, people with HTN are often on anti-hypertensive medication such as ACE inhibitors and angiotensin receptor blockers.…”

Section: Hypertension and Cardiovascular Morbiditymentioning

confidence: 99%

Metabolic and inflammatory health in SARS-CoV-2 and the potential role for habitual exercise in reducing disease severity

et al. 2021

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“…We noticed that Covid-19 infection was significantly associated with pre-existing HTN (p = 0.002). Pre-existing HTN was reported to present in up to is 32.7% amongst adult Covid-19 infected patients [27]. In children; a systemic review published by Rodriguez-Gonzalez and his colleagues revealed that; cardiovascular involvement seems to be a relevant factor of SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

Covid-19 in Egyptian hemodialysis and kidney transplant children: retrospective analysis of single center experience

et al. 2022

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Background Chronic kidney disease stage 5 (CKD 5) populations have peculiar risk for severe Covid-19 infection. Moreover; pediatric data are sparse and lacking. The aim of this study is to report our experience in CKD 5 children treated by hemodialysis (CKD 5D) and CKD 5 children after kidney transplantation (KTR) during one year of Covid-19 pandemic. Methods Retrospective analysis of 57 CKD 5 children with Covid-19 like symptoms during 1 year pandemic was performed. A cohort of 19 confirmed patients (13 CKD 5D and 6 KTR) was analyzed in details as regard clinical, laboratory, radiological criteria, management and their short term outcome. Results Conclusion Pediatric patients on regular HD (CKD 5D) are at higher risk and worse outcome of Covid-19 infection than KT recipients (KTR). Pre-existing HTN and shorter duration after KT are potential risk factors. Reversible AGD after KT and CVC related infections in HD patients are additional presenting features of Covid-19 infection.

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COVID-19 Outcomes Amongst Patients With Pre-existing Cardiovascular Disease and Hypertension

Cited by 10 publications

References 23 publications

MBL deficiency-causing B allele (rs1800450) as a risk factor for severe COVID-19

MBL deficiency-causing B allele (rs1800450) as a risk factor for severe COVID-19

Metabolic and inflammatory health in SARS-CoV-2 and the potential role for habitual exercise in reducing disease severity

Covid-19 in Egyptian hemodialysis and kidney transplant children: retrospective analysis of single center experience

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