COVID-19 mRNA vaccines and pathological cell-cell fusion: an unintended consequence

Sfera, Adonis; Thomas, Karina G; Sfera, DAN O; Anton, Jonathan J; Andronescu, Christina V; Jafri, Nyla; Sasannia, Sarvin; Kozlakidis, Zisis

doi:10.33425/2768-4598.1019

Cited by 2 publications

(3 citation statements)

References 113 publications

(149 reference statements)

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“… Spike protein has been shown to induce senescence in transfected cells [ 227 ]. Further, it has been proposed that the mRNA COVID-19 vaccines can induce premature senescence via syncytia formation in exposed immune cells, due primarily to their lipid content (ionizable lipids, cholesterol and the phospholipid 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)) [ 228 ]. In vitro molecular studies show that macromolecular crowding can facilitate the conversion of native PrP into the neurotoxic soluble β oligomer configuration [ 229 ].…”

Section: Evidence Of ‘Spikeopathy’—spike Protein Pathogenicitymentioning

confidence: 99%

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Parry,

Lefringhausen,

Turni

et al. 2023

Biomedicines

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The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse events have overshadowed the benefits. This two-part narrative review presents evidence for the widespread harms of novel product COVID-19 mRNA and adenovectorDNA vaccines and is novel in attempting to provide a thorough overview of harms arising from the new technology in vaccines that relied on human cells producing a foreign antigen that has evidence of pathogenicity. This first paper explores peer-reviewed data counter to the ‘safe and effective’ narrative attached to these new technologies. Spike protein pathogenicity, termed ‘spikeopathy’, whether from the SARS-CoV-2 virus or produced by vaccine gene codes, akin to a ‘synthetic virus’, is increasingly understood in terms of molecular biology and pathophysiology. Pharmacokinetic transfection through body tissues distant from the injection site by lipid-nanoparticles or viral-vector carriers means that ‘spikeopathy’ can affect many organs. The inflammatory properties of the nanoparticles used to ferry mRNA; N1-methylpseudouridine employed to prolong synthetic mRNA function; the widespread biodistribution of the mRNA and DNA codes and translated spike proteins, and autoimmunity via human production of foreign proteins, contribute to harmful effects. This paper reviews autoimmune, cardiovascular, neurological, potential oncological effects, and autopsy evidence for spikeopathy. With many gene-based therapeutic technologies planned, a re-evaluation is necessary and timely.

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Section: Evidence Of ‘Spikeopathy’—spike Protein Pathogenicitymentioning

confidence: 99%

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Parry,

Lefringhausen,

Turni

et al. 2023

Biomedicines

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show abstract

“…For further details regarding RNA technology, refer to reviews by Sahin U, et al [45] and Seneff S [46]. While cell entry of SARS-CoV-2 via binding of the spike protein subunit-1 to the ACE2 receptor followed by endocytosis is well known, recently, an alternative metalloproteinase pathway has been reported [47]. Here, cell entry occurs via cell cell fusion regulated by the furin cleavage site located within the spike protein subunit-2.…”

Section: Perspectivementioning

confidence: 99%

“…It is suggested that this pathway may explain the emergence of COVID-19 symptoms in fully vaccinated individuals. For further details, refer to review by Sfera A, et al [47].…”

Section: Perspectivementioning

confidence: 99%

Do COVID-19 RNA-Injections Affect Male Fertility? Latest Facts and Perspective

Bergholz¹,

Steger²

2023

J Biomed Res Environ Sci

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Background: Based on available data on male fertility adverse effects after COVID-19 injections, we draw the reader´s attention to open questions and undeniable risks of the new RNA-based vaccine technology. Methods: Review and reanalysis of published data on pre- and post-injection semen analyses. Evaluation of UK Yellow Card and US VAERS databases for male fertility adverse effects and of the German deStatis database for monthly live birth rates after start of the governmental vaccination program. Results: The deStatis database demonstrates a time shift of exactly nine months between the start of the governmental vaccination campaign (April 2021) and an abrupt decline in live births (January 2022). Frequency of male fertility adverse effects is approx. 100 times lower than that of female fertility. Remarkably, report numbers per one million doses are similar between AstraZeneca and BionTech/Pfizer, but significantly increased for Moderna despite overall numbers of administered doses are smaller than that of the other two manufacturers. Both increase in and correlation between erectile dysfunction and heart failure could be demonstrated. Review and reanalysis of published data on pre- and post-injection semen analyses identified a number of limitations of the currently available studies. Conclusion: There remain still far more questions than answers. Due to the principle “primum non nocere,” any new medical therapy must be banned until harmlessness beyond doubt has been proven. Most importantly, it must be realized that the active ingredient of RNA-based vaccines is not simply mRNA promoting the synthesis of a nota bene viral specific protein, but modRNA specifically designed for longevity and encapsulated in LNPs to bypass biological barriers and get access to all cells, possibly also germ cells. As mRNA is involved in regulation of gene expression, cells have mechanisms at hand to silence mRNA species not required, however, theses protective mechanisms will not work with modRNA.

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COVID-19 mRNA vaccines and pathological cell-cell fusion: an unintended consequence

Cited by 2 publications

References 113 publications

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

Do COVID-19 RNA-Injections Affect Male Fertility? Latest Facts and Perspective

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