COVID-19 mRNA vaccine may trigger subacute thyroiditis

Sözen, Mehmet; Topaloğlu, Ömercan; Çetinarslan, Berrin; Selek, Alev; Cantürk, Zeynep; Gezer, Emre; Köksalan, Damla; Bayraktaroğlu, Taner

doi:10.1080/21645515.2021.2013083

Cited by 38 publications

(30 citation statements)

References 19 publications

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“…Duration of treatment in vaccine-related SAT was reported as 8–12 weeks in other case series 35 . We previously reported the duration of SAT as 4–14 weeks in the patients with SAT developed either after BioNTech or CoronaVac 21 22 . We observed that SAT developed after the 1st dose of CoronaVac persisted after the 2nd dose in a patient up to a total of>90 days 21 .…”

Section: Discussionmentioning

confidence: 99%

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Differences in Clinical Aspects Between Subacute Thyroiditis Associated with COVID-19 Vaccines and Classical Subacute Thyroiditis

et al. 2022

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Subacute thyroiditis(SAT) developed after SARS-CoV-2 vaccines has been less studied. We aimed to compare classical SAT and SAT developed after SARS-CoV-2 vaccines in the context of clinical aspects. Adults with SAT detected in 90 days of COVID-19 vaccination (CoronaVac® or Pfizer/BioNTech®) were grouped as Vac-SAT (CoronaVac-SAT and BioNTech-SAT). Those with a history of SARS-CoV-2 or upper respiratory tract infection in 6 months before the vaccination, or vaccination with another antiviral vaccine after COVID-19 vaccination were excluded. Those with SAT detected before COVID-19 pandemic were grouped as Classical-SAT. Of total(n=85), female/male(54/31) ratio and age(43(23-65)) were similar in Vac-SAT(n=23) and Classical-SAT(n=62) groups. Duration between vaccine and SAT was 45(7-90) days, and similar in CoronaVac-SAT(n=5) and BioNTech-SAT(n=18) groups. SAT-duration was 28(10-150) days, and higher in Vac-SAT than in Classical-SAT group(p=0.023). SAT was developed after the 1st dose vaccine in minority in CoronaVac-SAT(n=2) and BioNTech-SAT(n=3) groups(p=0.263). Previous LT4 use, and TSH elevation after resolution were more frequent in Vac-SAT than in Classical-SAT(p=0.027 and p=0.041, respectively). We included a considerable number of patients with SAT occurred after COVID-19 vaccines. We cannot provide clear evidence regarding the association of COVID-19 vaccines with SAT. SAT associated with CoronaVac® or BioNTech® seems unlikely to be occurred after the 1st dose, and to have a longer duration, more likely to be associated with previous LT4 use and lead TSH elevation after resolution than Classical-SAT. TSH should be followed-up after the resolution of SAT detected after COVID-19 vaccination.

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Section: Discussionmentioning

confidence: 99%

“…Vaccination against COVID-19 has been continued since January 2021, in our country, Türkiye, by mRNA (BioNTech®) and inactive (CoronaVac®) vaccines [18]. A lot of cases of SAT developed after the COVID-19 vaccination have been observed and reported worldwide and from Türkiye [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Differences in Clinical Aspects Between Subacute Thyroiditis Associated with COVID-19 Vaccines and Classical Subacute Thyroiditis

et al. 2022

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“…Furthermore, subacute thyroiditis, that met the criteria for ASIA syndrome, was described following papillomavirus, influenza, hepatitis B, and, more recently, COVID‐19 vaccination. 25 , 26 , 27 , 28 , 29 , 30 , 31 In the context of ASIA, most dysthyroid patients were tested negative for thyroid antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…ASIA has been associated with several endocrine diseases (type 1 diabetes mellitus, premature ovarian failure and adrenal insufficiency). Furthermore, subacute thyroiditis, that met the criteria for ASIA syndrome, was described following papillomavirus, influenza, hepatitis B, and, more recently, COVID‐19 vaccination 25‐31 . In the context of ASIA, most dysthyroid patients were tested negative for thyroid antibodies.…”

Section: Discussionmentioning

confidence: 99%

Orbital inflammatory disease following mRNA SARS‐CoV‐2 vaccine

Grunenwald¹,

Lethellier

Imbert³

et al. 2022

Clinical Case Reports

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“…Regarding subacute thyroiditis, there are sporadic case reports in COVID-19 vaccine recipients. 2 , 3 The observed thyroid abnormality might or might not be associated with vaccination. After vaccination, the abnormal thyroid function might occur and it is not related to any immunological abnormality.…”

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confidence: 90%