COVID 19 mortality: Probable role of microbiome to explain disparity

Kumar, Pankaj; Chander, Bal

doi:10.1016/j.mehy.2020.110209

Cited by 28 publications

(31 citation statements)

References 31 publications

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“…Finally, selenocompound is an ex vivo compound originating mainly from gut microbiota [ 45 ], and the biological effect of its decrease needs further investigation. Both propanoate metabolism and selenocompound metabolism suggest potential roles played by gut microbiota in the progression of COVID-19, a topic which has gained increasing attention recently [ 41 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets

et al. 2021

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The novel coronavirus SARS-CoV-2 has spread across the world since 2019, causing a global pandemic. The pathogenesis of the viral infection and the associated clinical presentations depend primarily on host factors such as age and immunity, rather than the viral load or its genetic variations. A growing number of omics studies have been conducted to characterize the host immune and metabolic responses underlying the disease progression. Meta-analyses of these datasets have great potential to identify robust molecular signatures to inform clinical care and to facilitate therapeutics development. In this study, we performed a comprehensive meta-analysis of publicly available global metabolomics datasets obtained from three countries (United States, China and Brazil). To overcome high heterogeneity inherent in these datasets, we have (a) implemented a computational pipeline to perform consistent raw spectra processing; (b) conducted meta-analyses at pathway levels instead of individual feature levels; and (c) performed visual data mining on consistent patterns of change between disease severities for individual studies. Our analyses have yielded several key metabolic signatures characterizing disease progression and clinical outcomes. Their biological interpretations were discussed within the context of the current literature. To the best of our knowledge, this is the first comprehensive meta-analysis of global metabolomics datasets of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets

et al. 2021

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“…However, many developing areas seem to have outperformed developed areas in lowering the mortality rate, although the latter have better health-care facilities, higher-quality drinking water and sanitation, and longer life expectancy. 46 , 47 Some studies have proposed that the lower level of urbanization associated with decentralized population distribution in developing areas can retard the spread of the pandemic. 48 Long-term care facilities in developing areas are far from sufficient, and their accessibility depends on highly variable rural–urban divides and managerial standard of care.…”

Section: Literature Reviewmentioning

confidence: 99%

Global Population Aging, National Development Level, and Vulnerability to the Pandemic

Yuan

Zhao

et al. 2021

RMHP

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Purpose This study examined the roles of population aging and national development level in affecting different phases of novel coronavirus disease development with a view to advancing preparedness and corresponding policy. Methods Regression analysis was conducted using multisource data from the World Bank and Johns Hopkins COVID-19 Dashboard. Results Population aging is positively associated with confirmed cases of day-10, day-20, and day-30. The positive association between population aging and death does not emerge until day-20. Countries with a higher proportion of older males face higher risks of death.. Countries with a higher proportion of males aged 70–74 years are at the highest risk of confirmed cases. National development level is not associated with confirmed cases, but developing countries face significantly higher risks of death of day-10 and day-20. Conclusion Prevention and control policies for older adults and underdeveloped areas and sex differences need to be studied.

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“…Some studies suggest a decreased mortality rate may also be due to prior infections with gram negative bacteria (especially E. coli) and poor quality of water. 18 BCG vaccine given for tuberculosis in India, like any vaccine elicits an innate immune response and is expected to decrease the viral load. 18 However, there are other theories presented that explain India's high recovery rates and low death rates due to COVID-19 in contrast to developed countries.…”

Section: Comparison Of India Versus Other Developed Countriesmentioning

confidence: 99%

“…18 BCG vaccine given for tuberculosis in India, like any vaccine elicits an innate immune response and is expected to decrease the viral load. 18 However, there are other theories presented that explain India's high recovery rates and low death rates due to COVID-19 in contrast to developed countries. Of India's total population, 34.33% is expected to be the youth and as it's seen that there is a greater mortality in the elderly people due to COVID-19.…”

Section: Comparison Of India Versus Other Developed Countriesmentioning

confidence: 99%

India seems to outperform in handling COVID-19 pandemic

et al. 2021

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The coronavirus pandemic is an ongoing pandemic of coronavirus disease 2019 caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). The outbreak was first identified in Wuhan, China and soon within months it engulfed more than 188 countries. As of 25 January 2020, more than 100 million cases have been reported globally. Worst affected countries globally include USA, India, Brazil, Russian, UK, France, Turkey, Italy, Spain and Germany. By far India has taken robust immediate measures to contain the spread of virus by implementing stringent nationwide lockdowns at an early stage. This review focuses on how India, in several ways, is placed better in handling COVID-19 than the developed countries.

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COVID 19 mortality: Probable role of microbiome to explain disparity

Cited by 28 publications

References 31 publications

Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets

Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets

Global Population Aging, National Development Level, and Vulnerability to the Pandemic

India seems to outperform in handling COVID-19 pandemic

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