COVID-19: Mechanisms, risk factors, genetics, non-coding RNAs and neurologic impairments

Gilyazova, I. R.; Timasheva, Yanina; Карунас, А. С.; Казанцева, А.; Sufianov, Albert; Mashkin, Andrey; Korytina, G. F.; Wang, Yaolou; Gareev, Ilgiz; Хуснутдинова, Э. К.

doi:10.1016/j.ncrna.2023.02.007

Cited by 4 publications

(1 citation statement)

References 157 publications

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“…Interestingly, from this list miR‐15a‐5p and miR‐31‐5p appeared in two or more studies 56,57,73,78,82,84,86 and could potentially serve as biomarkers for disease severity. Table 3 summarises the targets and principle cellular pathways associated with miRNAs regulated during Inf vs C and S vs C stages and cited previously 46,56,73,88–120 . Most of the miRNAs were involved in targeting virus‐host interactions, viral replication, and host‐immune responses.…”

Section: Resultsmentioning

confidence: 97%

Differentially‐regulated miRNAs in COVID‐19: A systematic review

Ahmad

Gull

Baby

et al. 2023

Reviews in Medical Virology

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for coronavirus disease of 2019 that infected more than 760 million people worldwide with over 6.8 million deaths to date. COVID-19 is one of the most challenging diseases of our times due to the nature of its spread, its effect on multiple organs, and an inability to predict disease prognosis, ranging from being completely asymptomatic to death. Upon infection, SARS-CoV-2 alters the host immune response by changing host-transcriptional machinery. MicroRNAs (miRNAs) are regarded as post-transcriptional regulators of gene expression that can be perturbed by invading viruses. Several in vitro and in vivo studies have reported such dysregulation of host miRNA expression upon SARS-CoV-2 infection. Some of this could occur as an anti-viral response of the host to the viral infection. Viruses themselves can counteract that response by mounting their own pro-viral response that facilitates virus infection, an aspect which may cause pathogenesis. Thus, miRNAs could serve as possible disease biomarkers in infected people. In the current review, we have summarised and analysed the existing data about miRNA dysregulation in patients infected with SARS-CoV-2 to determine their concordance between studies, and identified those that could serve as potential biomarkers during infection, disease progression, and death, even in people with other comorbidities. Having such biomarkers can be vital in not only predicting prognosis, but also the development of novel miRNA-based anti-virals and Abbreviations: 3 0 UTR, 3 0 untranslated regions; 5 0 UTR, 5 0

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Section: Resultsmentioning

confidence: 97%