COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC)

Lamb, Laura E.; Dhar, Nivedita; Timar, Ryan; Wills, Mélissa; Dhar, Sorabh; Chancellor, Michael B.

doi:10.1016/j.mehy.2020.110375

Cited by 67 publications

(94 citation statements)

References 16 publications

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“…Further assessment of eligibility, based on full-text papers, led to the exclusion of nine papers. Finally, 16 studies involving a total of 575 patients infected with SARS-CoV-2 who had been evaluated for urinary and/or male genital involvement between January and June 2020 were included in the final analysis [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] (Figure 1). The characteristics of selected studies are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Urinary tract involvement was reported in five studies (Table 2). 26–29 In detail, de novo lower urinary tract symptoms (LUTS) and deterioration of pre‐existing LUTS occurred in 43 and 7 patients, respectively. Validated questionnaires to score LUTS were adopted in two studies 28,29 .…”

Section: Resultsmentioning

confidence: 99%

“…The infrequent presence of SARS‐CoV‐2 in urine samples from infected subjects has been interpreted as a sign in favor of the spread of the virus from the urethral endothelium to the bladder 15 . Some authors have recently hypothesized that, in patients with COVID‐19 and de novo severe urinary symptoms, an increase in inflammatory cytokines released into the urine and/or active in the bladder may be responsible for COVID‐19 Associated Cystitis (CAC) and of the associated bladder dysfunctions 26 …”

Section: Discussionmentioning

confidence: 99%

“…15 Some authors have recently hypothesized that, in patients with COVID-19 and de novo severe urinary symptoms, an increase in inflammatory cytokines released into the urine and/or active in the bladder may be responsible for COVID-19 Associated Cystitis (CAC) and of the associated bladder dysfunctions. 26 Recent literature data have reported that patients with CAC, both men and women, frequently refer to de novo lower urinary tract symptoms such as an increase in urinary frequency and nocturia, stressing the need that de novo urinary symptoms should be considered among the complex symptomatology of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

SARS‐CoV‐2 infection affects the lower urinary tract and male genital system: A systematic review

Creta

Sagnelli

Celentano

et al. 2021

Journal of Medical Virology

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PubMed, Scopus, and ISI Web of Knowledge databases were searched to identify studies published up to December 2020 on the involvement of urinary and male genital systems in COVID-19. Sixteen studies involving a total of 575 patients (538 males and 37 females) were included in this systematic review.The COVID-19 phase was available for 479 patients: 426 in the acute and 53 in the recovery phase. De novo lower urinary tract symptoms (LUTS) were observed in 43 patients and deterioration of pre-existing LUTS in 7. Bladder hemorrhage was observed in three patients and acute urinary retention in one.Regarding the male genital system, scrotal discomfort was observed in 8 patients, swelling in 14, pain in 16, and erythema in 1; low flow priapism was observed in 2 patients. Ultrasound examination identified acute orchitis in 10 patients, acute epididymitis in 7, and acute epididymo-orchitis in 16. A case-control study reported that patients with moderate COVID-19 show a significant reduction in sperm concertation, the total number of sperms per ejaculate, progressive motility, and complete motility. In contrast to what is known from the first studies on the subject, this review also includes subsequent studies that give evidence of the involvement of the lower urinary tract and male genital system in COVID-19.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

SARS‐CoV‐2 infection affects the lower urinary tract and male genital system: A systematic review

Creta

Sagnelli

Celentano

et al. 2021

Journal of Medical Virology

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show abstract

“…Despite being an unknown disease in 2019, COVID‐19 is now the focus of significant research efforts all over the world. We evaluated whether there was evidence to support the hypothesis that COVID‐19 infection caused long‐term bladder dysfunction, 6 consistent with initial case‐series which described COVID‐19 associated cystitis with acute SARS‐CoV‐2 infection 4 . We did not find that patients who were 66 years or older with laboratory‐confirmed COVID‐19 were at increased risk of receiving overactive bladder medication or having a urology consultation or cystoscopy in the 2–5 months after their diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Is coronavirus disease 2019 associated with indicators of long‐term bladder dysfunction?

Welk

Richard²,

Braschi

et al. 2021

Neurourology and Urodynamics

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Objective Early reports have suggested that coronavirus disease 2019 (COVID‐19) can present with significant urinary frequency and nocturia, and that these symptoms correlate with markers of inflammation in the urine. We evaluated surrogate markers of chronic urinary symptoms to determine if they were more frequent after COVID‐19 infection. Methods Routinely collected data from the province of Ontario was used to conduct a matched, retrospective cohort study. We identified patients 66 years of age or older who had a positive COVID‐19 test between February and May 2020 and survived at least 2 months after their diagnosis. We matched them to two similar patients who did not have a positive COVID‐19 test during the same time period. We measured the frequency of urology consultation, cystoscopy, and new prescriptions for overactive bladder medications during a subsequent 3‐month period. Proportional hazard models were adjusted for any baseline differences between the groups. Results We matched 5617 patients with COVID‐19 to 11,225 people who did not have COVID‐19. The groups were similar, aside from a higher proportion of patients having hypertension and diabetes in the CoVID‐19 cohort. There was no significantly increased hazard of new receipt of overactive bladder medication (hazards ratio [HR]: 1.04, p = 0.88), urology consultation (HR: 1.40, p = 0.10), or cystoscopy (HR: 1.14, p = 0.50) among patients who had COVID‐19, compared to the matched cohort. Conclusion Surrogate markers of potential bladder dysfunction were not significantly increased in the 2–5 months after COVID‐19 infection.

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Unrevealing the connection between real sample analysis and analytical method. The case of cytokines

Irimes

Tertiş

Oprean

et al. 2023

Medicinal Research Reviews

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Cytokines are compounds that belong to a special class of signaling biomolecules that are responsible for several functions in the human body, being involved in cell growth, inflammatory, and neoplastic processes. Thus, they represent valuable biomarkers for diagnosing and drug therapy monitoring certain medical conditions. Because cytokines are secreted in the human body, they can be detected in both conventional samples, such as blood or urine, but also in samples less used in medical practice such as sweat or saliva. As the importance of cytokines was identified, various analytical methods for their determination in biological fluids were reported. The gold standard in cytokine detection is considered the enzyme‐linked immunosorbent assay method and the most recent ones have been considered and compared in this study. It is known that the conventional methods are accompanied by a few disadvantages that new methods of analysis, especially electrochemical sensors, are trying to overcome. Electrochemical sensors proved to be suited for the elaboration of integrated, portable, and wearable sensing devices, which could also facilitate cytokines determination in medical practice.

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COVID-19 inflammation results in urine cytokine elevation and causes COVID-19 associated cystitis (CAC)

Cited by 67 publications

References 16 publications

SARS‐CoV‐2 infection affects the lower urinary tract and male genital system: A systematic review

SARS‐CoV‐2 infection affects the lower urinary tract and male genital system: A systematic review

Is coronavirus disease 2019 associated with indicators of long‐term bladder dysfunction?

Unrevealing the connection between real sample analysis and analytical method. The case of cytokines

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