COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes

Al-Hatamleh, Mohammad A. I.; Hatmal, Ma’mon M.; Alshaer, Walhan; Rahman, Engku Nur Syafirah Engku Abd; Mohd-Zahid, Manali Haniti; Alhaj-Qasem, Dina M.; Yean, Chan Yean; Alias, Iskandar Zulkarnain; Jaafar, Juhana; Ferji, Khalid; Six, Jean‐Luc; Uskoković, Vuk; Yabu, Hiroshi; Mohamud, Rohimah

doi:10.1016/j.ejphar.2021.173930

Cited by 26 publications

(24 citation statements)

References 146 publications

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“…Since the outbreak of the disease, various countries have reached the conclusion that the accurate, efficient, comprehensive, reliable, and up-to-date assessment of available information plays a vital role in the effective management of this incident (9). Although several therapeutic compounds and drugs have been recommended to overcome COVID-19, they are often considered supportive treatment options (10,11).…”

Section: Contextmentioning

confidence: 99%

Common Side Effects of COVID-19 Vaccines Used in Iran: A Review

Siahvoshi

Movahed

Ghods

2022

Ann Mil Health Sci Res

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Context: Iran was one of the first countries in the world to encounter acute respiratory syndrome coronavirus 2 in February 2020. Numerous efforts have been made worldwide to develop safe and effective vaccines to prevent coronavirus disease 2019 (COVID-19). Finally, several vaccines with different platforms have been licensed for use in various countries. The injection of these vaccines can lead to a range of unwanted side effects (mild to severe). Objectives: This study tried to collect the common adverse effects of the most frequently used COVID-19 vaccines in Iran and provide readers with relevant information and statistics. Methods: This review study collected papers by searching in foreign journals using databases, such as PubMed, PubMed Central, MEDLINE, EBSCO, Google Scholar, and Embase, with the keywords of side effects, COVID-19, vaccine, AstraZeneca, Sputnik V, and Sinopharm, which were published within 2000-2021. Results: According to available information and studies, vaccines, unlike COVID-19, do not have any threatening and high-risk side effects, and their benefits outweigh their insignificant side effects. A total of 48 full-text studies and 10 valid websites with high citations and up-to-date information were selected. Among the relevant references, 26, 16, and 16 studies performed on AstraZeneca, Sputnik V, and Sinopharm vaccines were chosen for review, respectively. Conclusions: The findings of this study can reassure readers and be effective in combating misconceptions about vaccination. Undoubtedly, the main solution to overcome the economic damage and social health burden caused by the COVID-19 pandemic is to accelerate global vaccination.

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Section: Contextmentioning

confidence: 99%

Common Side Effects of COVID-19 Vaccines Used in Iran: A Review

Siahvoshi

Movahed

Ghods

2022

Ann Mil Health Sci Res

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“…The virus has rapidly spread across the world, resulting in a worldwide pandemic that has lasted through this moment [1]. Although many therapeutic compounds and drugs have been suggested and repurposed in the fight against COVID-19, they remained as supportive treatment options [2,3].…”

Section: Introductionmentioning

confidence: 99%

Side Effects and Perceptions Following COVID-19 Vaccination in Jordan: A Randomized, Cross-Sectional Study Implementing Machine Learning for Predicting Severity of Side Effects

et al. 2021

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Background: Since the coronavirus disease 2019 (COVID-19) was declared a pandemic, there was no doubt that vaccination is the ideal protocol to tackle it. Within a year, a few COVID-19 vaccines have been developed and authorized. This unparalleled initiative in developing vaccines created many uncertainties looming around the efficacy and safety of these vaccines. This study aimed to assess the side effects and perceptions following COVID-19 vaccination in Jordan. Methods: A cross-sectional study was conducted by distributing an online survey targeted toward Jordan inhabitants who received any COVID-19 vaccines. Data were statistically analyzed and certain machine learning (ML) tools, including multilayer perceptron (MLP), eXtreme gradient boosting (XGBoost), random forest (RF), and K-star were used to predict the severity of side effects. Results: A total of 2213 participants were involved in the study after receiving Sinopharm, AstraZeneca, Pfizer-BioNTech, and other vaccines (38.2%, 31%, 27.3%, and 3.5%, respectively). Generally, most of the post-vaccination side effects were common and non-life-threatening (e.g., fatigue, chills, dizziness, fever, headache, joint pain, and myalgia). Only 10% of participants suffered from severe side effects; while 39% and 21% of participants had moderate and mild side effects, respectively. Despite the substantial variations between these vaccines in the presence and severity of side effects, the statistical analysis indicated that these vaccines might provide the same protection against COVID-19 infection. Finally, around 52.9% of participants suffered before vaccination from vaccine hesitancy and anxiety; while after vaccination, 95.5% of participants have advised others to get vaccinated, 80% felt more reassured, and 67% believed that COVID-19 vaccines are safe in the long term. Furthermore, based on the type of vaccine, demographic data, and side effects, the RF, XGBoost, and MLP gave both high accuracies (0.80, 0.79, and 0.70, respectively) and Cohen’s kappa values (0.71, 0.70, and 0.56, respectively). Conclusions: The present study confirmed that the authorized COVID-19 vaccines are safe and getting vaccinated makes people more reassured. Most of the post-vaccination side effects are mild to moderate, which are signs that body’s immune system is building protection. ML can also be used to predict the severity of side effects based on the input data; predicted severe cases may require more medical attention or even hospitalization.

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“…Therefore, nanomedicine is extensively acclaimed as potential probe agents in detecting and treating coronavirus 2 (SARS-CoV-2), MERS-CoV, ZIKA and other viral infections. These novel nanotherapeutics reduced inflammation and controlled fulminant cytokine storm when COVID-19 infections transpired [3]. The various immunological phases were identified by the decrease of CD 4+ , CD 8+ , T-lymphocytes (lymphopenia), and CD 4+ cell expression of INF-γ.…”

Section: Globalize Your Researchmentioning

confidence: 99%

Nanomedicine, Viral Infection and Cytokine Stor

Kumar¹,

Mohammadipanah²

2021

IJCCR

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Recently, emerged outbreaks of various viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MERS-CoV, and ZIKA infections, are fatal for human life. These life-threatening infections to public health pointed out as a major cause responsible for initiating severe diseases globally. These viral infections heightened the morbidity rates and thus, it is a deadly fear to human life. Researchers left no stone unturned for searching newer therapeutic targets and remedies to treat these viral infections and outbreaks. Simultaneously, some of the researchers have gained success in the discovery of an efficient treatment and development of an effective vaccine [1]. In view of that, numerous developments have been made for innovating nanotherapies, which can treat viral infection and few of them are written off as nanomedicine, have been become reality.

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COVID-19 infection and nanomedicine applications for development of vaccines and therapeutics: An overview and future perspectives based on polymersomes

Cited by 26 publications

References 146 publications

Common Side Effects of COVID-19 Vaccines Used in Iran: A Review

Common Side Effects of COVID-19 Vaccines Used in Iran: A Review

Side Effects and Perceptions Following COVID-19 Vaccination in Jordan: A Randomized, Cross-Sectional Study Implementing Machine Learning for Predicting Severity of Side Effects

Nanomedicine, Viral Infection and Cytokine Stor

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