COVID-19 Infection among Older People Admitted to Hospital: A Cross-Sectional Analysis

Thiam, Chiann Ni; Hasmukharay, Kejal; Lim, Wan Chieh; Ng, Chai Chen; Pang, Gordon Hwa Mang; Abdullah, Aimy; Saedon, Nor Izzati; Khor, Hui Min; Ong, Terence

doi:10.3390/geriatrics6010025

Cited by 7 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two articles not reported in Malaysia were removed. Eventually, five studies (four from the databases and the present study) were consistent with the inclusion requirements [ 23 , 24 , 25 , 26 ]. Figure 1 illustrates the flow of this study.…”

Section: Resultsmentioning

confidence: 88%

Prevalence of Coronavirus Disease 2019 (COVID-19) in Different Clinical Stages before the National COVID-19 Vaccination Programme in Malaysia: A Systematic Review and Meta-Analysis

Chong

Tan

et al. 2022

IJERPH

View full text Add to dashboard Cite

More than 1.75 million COVID-19 infections and 16 thousand associated deaths have been reported in Malaysia. A meta-analysis on the prevalence of COVID-19 in different clinical stages before the National COVID-19 Vaccination Program in Malaysia is still lacking. To address this, the disease severity of a total of 215 admitted COVID-19 patients was initially recorded in the early phase of this study, and the data were later pooled into a meta-analysis with the aim of providing insight into the prevalence of COVID-19 in 5 different clinical stages during the outset of the COVID-19 pandemic in Malaysia. We have conducted a systematic literature search using PubMed, Web of Science, Scopus, ScienceDirect, and two preprint databases (bioRxiv and medRxiv) for relevant studies with specified inclusion and exclusion criteria. The quality assessment for the included studies was performed using the Newcastle–Ottawa Scale. The heterogeneity was examined with an I2 index and a Q-test. Funnel plots and Egger’s tests were performed to determine publication bias in this meta-analysis. Overall, 5 studies with 6375 patients were included, and the pooled prevalence rates in this meta-analysis were calculated using a random-effect model. The highest prevalence of COVID-19 in Malaysia was observed in Stage 2 cases (32.0%), followed by Stage 1 (27.8%), Stage 3 (17.1%), Stage 4 (7.6%), and Stage 5 (3.4%). About two-thirds of the number of cases have at least one morbidity, with the highest percentage of hypertension (66.7%), obesity (55.5%), or diabetes mellitus (33.3%) in Stage 5 patients. In conclusion, this meta-analysis suggested a high prevalence of COVID-19 occurred in Stage 2. The prevalence rate in Stage 5 appeared to be the lowest among COVID-19 patients before implementing the vaccination program in Malaysia. These meta-analysis data are critically useful for designing screening and vaccination programs and improving disease management in the country.

show abstract

Section: Resultsmentioning

confidence: 88%

Prevalence of Coronavirus Disease 2019 (COVID-19) in Different Clinical Stages before the National COVID-19 Vaccination Programme in Malaysia: A Systematic Review and Meta-Analysis

Chong

Tan

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…6 In the present study, younger patients mainly presented with respiratory and gastrointestinal symptoms, whereas older patients mainly presented atypically with delirium (13.0%) and lethargy (33.8%), compared with 19.2% of patients with nonrespiratory (atypical) symptoms reported in a study at University Malaya Medical Centre. 7 Patients usually develop more symptoms over time; the presenting symptoms could have been documented at various time points during the infection. This may result in differences between the studies.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics between older and younger patients with COVID-19 infection in a tertiary hospital: a retrospective cross-sectional study

Zam

Sirimanne

et al. 2023

Asian Journal of Gerontology and Geriatrics

View full text Add to dashboard Cite

Objective. This study aims to compare older and younger patients with COVID-19 infection in terms of patient characteristics, presenting symptoms, laboratory parameters, complications, treatment received, and outcomes.Methods. Medical records of patients aged ≥12 years who were admitted to Hospital Tengku Ampuan Rahimah between 1 January 2021 and 31 June 2021 with polymerase chain reaction-proven COVID-19 infection were retrospectively reviewed. Data collected included sociodemographic data (age, ethnicity, sex, and residence), comorbidities, COVID-19 presentation (acute presenting symptoms, primary working diagnosis, disease severity, laboratory parameters on admission, and treatment received), and outcomes (complications, length of hospital stay, discharge destination, oxygen support required, and mortality).Results. A total of 259 patients aged 18 to 91 years were admitted to our hospital with COVID-19 infection. Of them, 182 (70.3%) were younger patients and 77 (29.7%) were older patients (aged >60 years). More older patients than younger patients had comorbidities (87.0% vs 49.5%, p<0.001) and presented with delirium (13% vs 0.5%, p<0.001) and lethargy (33.8% vs 15.9%, p=0.001). More older patients had severe COVID-19 infection (72.7% vs 38.5%, p<0.001), with 9.1% necessitating intubation. More older patients were prescribed favipiravir (64.9% vs 32.4%, p<0.001), antibiotics (76.6% vs 44%, p<0.001), and steroid (75.3% vs 40.1%, p<0.001). More older patients required intensive care (32.5% vs 17%, p=0.003). More older patients developed complications such as secondary infection (41.6% vs 17%, p<0.001) and acute kidney injury necessitating dialysis (20.8% vs 8.8%, p=0.005). Older patients had longer length of hospital stay (14 vs 12 days, p<0.001) and higher mortality (18.2% vs 4.4%, p<0.001). Conclusion.Older patients with COVID-19 infection tend to have more severe disease, higher complication rate, and higher mortality. Timely management is essential to minimise morbidity and mortality.

show abstract

“…SARS CoV-2 virüsünün neden olduğu COVID-19 hastalığının seyrinde yaş önemlidir. Yaşlı hastalarda COVID-19 enfeksiyonu daha ağır seyretmektedir (28) . Onder ve ark.…”

Section: Bulgularunclassified

The Importance of SARS CoV 2 RT-PCR Positivity and Hematologic Parameters in COVID-19 Patients

Akıneden¹,

Çiçek²,

Türkel³

et al. 2022

Turk Mikrobiyol Cemiy Derg

View full text Add to dashboard Cite

Ct değerlerinde yoğun bakım ve servis hastaları arasında fark gözlemlenmedi (p=0.068). İki hasta grubu arasında; lökosit, nötrofil, trombosit, plateletkrit ve trombosit/lenfosit oranı değerleri arasında fark bulunamadı (p>0.05). Ancak, yoğun bakım hastalarında servis hastalarına göre lenfosit, eosinofil, eritrosit ve hemoglobin değerlerinde düşme görüldü. Öte yandan eritrosit dağılım genişliği-varyasyon katsayısı, eritrosit dağılım genişliği-standart sapma, trombosit, ortalama trombosit volümü, trombosit dağılım genişliği ve nötrofil/lenfosit oranı değerinde yükselme saptandı. Sonuç: Çalışmamıza göre, servis ve yoğun bakımda yatış açısından RT-PCR Ct değerlerinin bir anlamı olmadığı, ancak hematolojik parametrelerin takibinin önemli olduğu sonucuna varıldı.

show abstract

COVID-19 Infection among Older People Admitted to Hospital: A Cross-Sectional Analysis

Cited by 7 publications

References 31 publications

Prevalence of Coronavirus Disease 2019 (COVID-19) in Different Clinical Stages before the National COVID-19 Vaccination Programme in Malaysia: A Systematic Review and Meta-Analysis

Prevalence of Coronavirus Disease 2019 (COVID-19) in Different Clinical Stages before the National COVID-19 Vaccination Programme in Malaysia: A Systematic Review and Meta-Analysis

Clinical characteristics between older and younger patients with COVID-19 infection in a tertiary hospital: a retrospective cross-sectional study

The Importance of SARS CoV 2 RT-PCR Positivity and Hematologic Parameters in COVID-19 Patients

Contact Info

Product

Resources

About