COVID-19 Induced Pancytopenia in a Major Molecular Response CML patient on Dasatinib: A Case Report and Review of Literature

During the COVID-19 pandemic, it was recognised that SARS-CoV-2 can cause multisystem illness. Non-respiratory complications observed early in the pandemic were haematological in nature. A rare but serious haematological complication of COVID-19 infection is pancytopaenia. We describe a case of an older adult without pre-existing haematological disease or risk factors for cell dyscrasia with severe pancytopaenia induced by COVID-19, who developed critical illness requiring respiratory support in intensive care and died. Our case report highlights that de novo pancytopaenia may only present with mild dermatological manifestations and may indicate severe COVID-19 infection. Management is primarily supportive and early involvement of haematology should be sought.

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De novo pancytopaenia in an older adult with severe COVID-19 infection

Lee

Thein

Muneer

2022

BMJ Case Rep

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Case Report: COVID Associated Pancytopenia Unmasking Previously Undiagnosed Pernicious Anemia

Barranco-Trabi

Minns

Akter

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated pancytopenia is a known but rare complication of COVID-19 syndrome that is not well described in literature. Severe acute respiratory syndrome coronavirus 2 has shown the potential to affect any organ including the bone marrow, which then results in a decrease in all three blood cell lines. These cases usually resolve with the passage of time and treatment of underlying risk factors. As COVID pneumonia rates continue to increase worldwide, it is crucial to be able to recognize this complication. Additionally, deeper investigation into patient’s response to COVID infection can be complicated by unexpected underlying disease. We report a case of a symptomatic 24-year-old active duty male in Hawaii with post-COVID pancytopenia that was found to have previously undiagnosed pernicious anemia and his response to standard treatment.

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COVID-19 and Subsequent Development of Pancytopenia With Concurrent Disseminated Intravascular Coagulation

Dube¹,

Sapkota²,

Lakhatariya³

et al. 2022

Cureus

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Complications resulting from coronavirus disease 2019 (COVID-19) sequelae have been well documented. These include blood conditions such as lymphopenia, thrombocytopenia, and hypercoagulability. Less common problems that may arise are disseminated intravascular coagulation (DIC), immune thrombocytopenic purpura (ITP), and pancytopenia. Furthermore, the majority of COVID-19 patients to develop pancytopenia have been immunosuppressed. We present a case of a previously immunocompetent patient who subsequently developed pancytopenia, DIC, as well as symptoms of ITP one month after being diagnosed with COVID-19.

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COVID-19 Induced Pancytopenia in a Major Molecular Response CML patient on Dasatinib: A Case Report and Review of Literature

Cited by 3 publications

References 14 publications

De novo pancytopaenia in an older adult with severe COVID-19 infection

De novo pancytopaenia in an older adult with severe COVID-19 infection

Case Report: COVID Associated Pancytopenia Unmasking Previously Undiagnosed Pernicious Anemia

COVID-19 and Subsequent Development of Pancytopenia With Concurrent Disseminated Intravascular Coagulation

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