COVID-19 induced liver injury from a new perspective: Mitochondria

Akbari, Hassan; Taghizadeh‐Hesary, Farzad

doi:10.1016/j.mito.2023.04.001

Cited by 9 publications

(4 citation statements)

References 93 publications

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“…It has been shown on a cellular level that remdesivir can be toxic to human hepatocytes, although the exact mechanism is unknown [55]. Emerging evidence suggests that remdesivir may interfere with mitochondrial function in hepatocytes, leading to oxidative stress and cell injury [56]. Additionally, the upregulation of pro-inflammatory cytokines in response to SARS-CoV-2 infection, coupled with remdesivir's pharmacological effects, might exacerbate liver inflammation, thereby potentiating hepatotoxicity [57].…”

Section: Remdesivir-associated Hepatotoxicitymentioning

confidence: 99%

Remdesivir and the Liver: A Concise Narrative Review of Remdesivir-Associated Hepatotoxicity in Patients Hospitalized Due to COVID-19

FakhriRavari,

Malakouti

2024

Pharmacoepidemiology

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Severe acute respiratory syndrome coronavirus 2 has infected millions of people, but about 20% of infected individuals do not develop symptoms. COVID-19 is an inflammatory disease that affects a portion of individuals infected with the virus and it is associated with liver injury and other complications, leading to hospitalization, critical illness, and death. Remdesivir is an antiviral agent used for the treatment of hospitalized patients with COVID-19 to improve the time to recovery, reduce the duration of mechanical ventilation, decrease the need for supplemental oxygen, and decrease the risk of mortality. Remdesivir-associated hepatotoxicity has been observed as increased transaminases more than five times the upper limit of normal in hospitalized patients with COVID-19, but causality has not been proven. It is generally difficult to distinguish between remdesivir-associated hepatotoxicity and COVID-19-induced hepatotoxicity. The purpose of this review is to evaluate the evidence for remdesivir-associated hepatotoxicity. Current evidence suggests that elevated liver enzymes in hospitalized COVID-19 patients are more likely to be due to the infection than remdesivir, and a 5-day course of remdesivir seems to be safe in regard to hepatotoxicity.

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Section: Remdesivir-associated Hepatotoxicitymentioning

confidence: 99%

Remdesivir and the Liver: A Concise Narrative Review of Remdesivir-Associated Hepatotoxicity in Patients Hospitalized Due to COVID-19

FakhriRavari,

Malakouti

2024

Pharmacoepidemiology

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“…SARS-CoV-2 enters the cells, and the RNA and RNA transcripts capture the mitochondria, and disrupt the mitochondrial electron transport chain (60). Prasada Kabekkodu et al suggested that SARS CoV proteins localize in the mitochondria, increase reactive oxygen species (ROS) levels, perturbation of Ca2+ signaling, changes in mtDNA copy number, mitochondrial membrane potential (MMP), mitochondrial mass, and induction of mitophagy (61).…”

Section: Covid-19 Virus Influences Mitochondria Of the Infected Patientmentioning

confidence: 99%

Mitochondrial oxidative stress, mitochondrial ROS storms in long COVID pathogenesis

Noonong,

Chatatikun,

Surinkaew

et al. 2023

Front. Immunol.

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SignificanceThis review discusses the coronavirus disease 2019 (COVID-19) pathophysiology in the context of diabetes and intracellular reactions by COVID-19, including mitochondrial oxidative stress storms, mitochondrial ROS storms, and long COVID.Recent advancesThe long COVID is suffered in ~10% of the COVID-19 patients. Even the virus does not exist, the patients suffer the long COVID for even over a year, This disease could be a mitochondria dysregulation disease.Critical issuesPatients who recover from COVID-19 can develop new or persistent symptoms of multi-organ complications lasting weeks or months, called long COVID. The underlying mechanisms involved in the long COVID is still unclear. Once the symptoms of long COVID persist, they cause significant damage, leading to numerous, persistent symptoms.Future directionsA comprehensive map of the stages and pathogenetic mechanisms related to long COVID and effective drugs to treat and prevent it are required, which will aid the development of future long COVID treatments and symptom relief.

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“…These compounds are recognized for their positive health effects, particularly as antiatherogenic, anticancer, neuroprotective, antidiabetic, lipid-regulating, and anti-obesity, and in promoting cardiovascular health-related benefits [55]. Their antimicrobial and antiviral were also investigated, particularly against COVID-19 effects, as hydroxytyrosol promotes mitochondrial function through activating mitophagy [56]; improving the mitochondria metabolism can reduce the severity of SARCS-COV-2 effects on hepatocytes' mitochondria, ameliorating COVID-induced liver injury [57].…”

Section: Wine Compoundsmentioning

confidence: 99%

Beyond the Bottle: Exploring Health-Promoting Compounds in Wine and Wine-Related Products—Extraction, Detection, Quantification, Aroma Properties, and Terroir Effects

Marques,

Dinis,

Santos

et al. 2023

Foods

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Health-promoting compounds in wine and wine-related products are important due to their potential benefits to human health. Through an extensive literature review, this study explores the presence of these compounds in wine and wine-related products, examining their relationship with terroir and their impact on the aromatic and flavor properties that are perceived orally: sunlight exposure, rainfall patterns, and soil composition impact grapevines’ synthesis and accumulation of health-promoting compounds. Enzymes, pH, and the oral microbiome are crucial in sensory evaluation and perception of health promotion. Moreover, their analysis of health-promoting compounds in wine and wine-related products relies on considerations such as the specific target compound, selectivity, sensitivity, and the complexity of the matrix.

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COVID-19 induced liver injury from a new perspective: Mitochondria

Cited by 9 publications

References 93 publications

Remdesivir and the Liver: A Concise Narrative Review of Remdesivir-Associated Hepatotoxicity in Patients Hospitalized Due to COVID-19

Remdesivir and the Liver: A Concise Narrative Review of Remdesivir-Associated Hepatotoxicity in Patients Hospitalized Due to COVID-19

Mitochondrial oxidative stress, mitochondrial ROS storms in long COVID pathogenesis

Beyond the Bottle: Exploring Health-Promoting Compounds in Wine and Wine-Related Products—Extraction, Detection, Quantification, Aroma Properties, and Terroir Effects

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