COVID-19-Induced Guillain-Barré Syndrome

Brooks, Joseph E.; Mix, Felicia M.; Buck, J; Walters, Reid A.

doi:10.7759/cureus.19809

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…As GBS is known to occur following infection, it has been reported in cases following the novel COVID-19 infection. In contrast to the patient presented in this report, other cases of post-COVID GBS have presented akin to the classic description [ 7 ]. The patient presented in this case initially had asymmetric symptoms, with the paresthesias in her right hallux being the primary sign.…”

Section: Discussioncontrasting

confidence: 78%

Atypical Guillain-Barré Syndrome Presenting After COVID-19 Infection

Noon¹,

Malhi²,

Wong³

2022

Cureus

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Guillain-Barré syndrome (GBS) is an acute autoimmune disease affecting the peripheral nervous system presenting as a symmetric, ascending polyneuropathy. The syndrome arises after a stimulus, such as infection or vaccination, and provokes an autoimmune response in the body. Common symptoms include rapidly progressive weakness in the extremities and generalized hyporeflexia or areflexia. However, GBS may have various presentations, which can make for a challenging diagnosis. We present a case of a 46-year-old female with asymmetric ascending weakness, paresthesias, and acute onset urinary retention occurring after Coronavirus Disease 2019 (COVID-19) infection. Of note, this patient did not present with albuminocytologic dissociation in cerebrospinal fluid (CSF) studies. The complex presentation of her symptoms prompted a diagnosis of atypical GBS. Her diagnosis was achieved through a series of diagnostic tests ruling out other etiologies, such as meningitis and spinal cord compression syndromes.

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Section: Discussioncontrasting

confidence: 78%

Atypical Guillain-Barré Syndrome Presenting After COVID-19 Infection

Noon¹,

Malhi²,

Wong³

2022

Cureus

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“…However, a diverse range of extrapulmonary manifestations has been identified in recent studies [ 2 - 4 ]. One complication is Guillain-Barre syndrome (GBS), a rare neurological disorder that manifests with a characteristic ascending limb paralysis preceded by an acute respiratory or gastrointestinal infection [ 5 , 6 ]. Bilateral paralysis of the facial nerves, particularly at the clinical onset of GBS, is extremely unusual.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Facial Paralysis in an Atypical Clinical Onset of COVID-Associated Guillain-Barre Syndrome

Taftaf,

Vera Cruz,

Al-Qasmi

et al. 2024

Cureus

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Coronavirus disease (COVID-19) has been associated with a diverse range of extrapulmonary manifestations since its global outbreak in 2019. One of its rare complications is Guillain-Barre Syndrome (GBS), a post-infectious neurological disorder that manifests with a characteristic ascending limb paralysis. Here, we describe the atypical case of a 42-year-old African American male who developed bilateral facial paralysis within five weeks of testing positive for COVID-19. Initial diagnostic imaging and blood studies were negative for acute pathology. Albuminocytological dissociation found in a subsequent analysis of the patient’s cerebrospinal fluid and his appropriate therapeutic response to intravenous immunoglobulin (IVIg) indicated GBS as the most likely diagnosis.

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“…Brooks et al (2021),Randhawa et al (2021) e McGann et al (2021 em seus estudos de caso também identificaram uma média de idade de 41 anos (faixa entre 33-63 anos), corroborando com os dados encontrados no estudo.…”

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Caracterização da síndrome de Guillain-Barré pós COVID-19 em uma clínica privada no interior da Amazônia – relato de uma série de casos

Sousa

Navarro

Honorato

et al. 2022

RSD

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Objetivos: relatar casos de Síndrome Guillain-Barré pós-COVID-19 em uma cidade no interior da Amazônia, caracterizar a evolução do quadro clínico, diagnóstico e desfecho da doença, retratar as semelhanças e diferenças entre os pacientes e evidenciar a importância da valorização da Síndrome Guillain-Barré pós-COVID-19. Métodos: trata-se de uma série de casos composta por seis pacientes com quadro compatível com a Síndrome de Guillain-Barré relacionada à infecção prévia pela COVID-19. É um estudo de natureza observacional e descritiva e os dados foram coletados retrospectivamente a partir da análise dos prontuários de uma clínica privada localizada em Santarém, estado do Pará, Brasil. Resultados e Discussão: Todos os pacientes apresentaram diagnóstico clínico e laboratorial da COVID-19, e em seguida a Síndrome de Guillain-Barré. Neste estudo, o comprometimento motor foi predominante e nem sempre seguiu padrão ascendente. O exame de líquor teve resultado variável e sem as anormalidades típicas. A eletroneuromiografia revelou que o comprometimento axonal era predominante. A maioria dos pacientes evoluíram com recuperação funcional e apenas um deles apresentou-se sem melhora. O tratamento com imunoglobulina intravenosa parece ter contribuído para um desfecho positivo. Os dados encontrados são compatíveis com estudos em outras regiões do mundo. Conclusão: A Síndrome de Guillain-Barré pós-COVID-19 pode ter manifestações clínicas, laboratoriais e neurofisiológicas diferentes do habitual e pode ter uma evolução variável, sendo o diagnóstico precoce essencial para o tratamento mais assertivo e menor risco de sequela. Isso se tornar um desafio em lugares remotos e pequenas cidades da Amazônia, onde o acesso à saúde é mais precário.

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COVID-19-Induced Guillain-Barré Syndrome

Cited by 4 publications

References 10 publications

Atypical Guillain-Barré Syndrome Presenting After COVID-19 Infection

Atypical Guillain-Barré Syndrome Presenting After COVID-19 Infection

Bilateral Facial Paralysis in an Atypical Clinical Onset of COVID-Associated Guillain-Barre Syndrome

Caracterização da síndrome de Guillain-Barré pós COVID-19 em uma clínica privada no interior da Amazônia – relato de uma série de casos

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