COVID-19-induced granulomatosis with polyangiitis

Selvaraj, Vijairam; Moustafa, Abdelmoniem; Dapaah-Afriyie, Kwame; Birkenbach, Mark

doi:10.1136/bcr-2021-242142

Cited by 30 publications

(27 citation statements)

References 8 publications

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“…Their results confirmed the molecular autoantigen transformation and post-translational modifications due to the influence of the SARS-CoV-2 virus on host cells. These findings support the reports about the appearance of autoimmune diseases after COVID-19 [44][45][46] and confirm their nonrandomness. In all cases, the autoimmune pathology occurred after the end of the clinical manifestation of COVID-19.…”

Section: Long Covid From An Autoimmune Perspectivesupporting

confidence: 91%

COVID-19 from a rheumatology perspective: bibliometric and altmetric analysis

et al. 2021

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The Coronavirus disease 2019 (COVID-19) outbreak turned out the greatest pandemic for decades. It challenged enormously the global health system, forcing it to adjust to the new realities. We aimed to analyze articles covering COVID-19 papers in the rheumatological field and outline emerging topics raising within this frame. We applied the bibliometric database Scopus for our literature search and conducted it on the 5th of June using the following keywords: "rheumatic" OR "rheumatology" OR "rheumatoid arthritis" OR "systemic lupus erythematosus" OR "myositis" OR "systemic sclerosis" OR "vasculitis" OR "arthritis" OR "ankylosing spondylitis" AND "COVID-19". We analyzed all selected articles according to various aspects: type of document, authorship, journal, citations score, rheumatology field, country of origin, language, and keywords. With the help of the software tool VOSviewer version 1.6.15, we have built the visualizing network of authors and keywords co-occurrence. The measurement of the social impact of articles was made using Altmetric data. This study included 1430 retrieved articles with open access mostly. The top five journals in this field were Annals of the Rheumatic Diseases (n = 65), Rheumatology International (n = 51), Clinical Rheumatology (n = 50), Lancet Rheumatology (n = 50), and Frontiers In Immunology (n = 33). Most studies originate from countries with a high incidence of COVID-19 among the general population (the USA-387; Italy-268; . Original Articles (42.1%) were the most common articles' type, following by Letters (24.4%), Reviews (21.7%), Notes (6%), Editorials (4.8%), Erratum (1%). According to the citations scores, articles dedicated to the clinical course of COVID-19 in patients with rheumatic diseases were of the highest importance for the scientific rheumatologic community. Rheumatoid arthritis (n = 527), systemic lupus erythematosus (n = 393), vasculitis (n = 267), myositis (n = 71), systemic sclerosis (n = 68), and psoriatic arthritis (n = 68) were the most widely discussed rheumatic diseases in the view of COVID-19. The analysis of Altmetric and citations scores revealed a moderate correlation between them. This article provides a comprehensive bibliometric and altmetric analysis of COVID-19 related articles in the rheumatology field and summarizes data about features of rheumatology service in the time of the pandemic.

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Section: Long Covid From An Autoimmune Perspectivesupporting

confidence: 91%

COVID-19 from a rheumatology perspective: bibliometric and altmetric analysis

et al. 2021

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“…Other proposed etiopathogenetic mechanisms have been related to (i) the presence of a persistent inflammatory status with the production of proinflammatory cytokines that may hamper the inner ear functions 36 ; and (ii) to the concomitant onset of an autoimmune response, such as granulomatosis with polyangiitis. 40 Drawbacks. This review considered among other data individual reports and case series (level of evidence 4), therefore it is susceptible to information bias, which might represent a limitation of the study.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Fancello

Hatzopoulos

Corazzi

et al. 2021

Int J Immunopathol Pharmacol

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To describe the audio-vestibular disorders related to the newly SARS-CoV-2 infection, including the possible ototoxicity side-effects related to the use of drugs included in the SARS-CoV-2 treatment protocols. A systematic review was performed according to the PRISMA protocol. The Medline and Embase databases were searched from March 1, 2020 to April 9, 2021. Initially the search yielded 400 manuscripts, which were reduced to 15, upon the application of inclusion criteria. Sensorineural hearing loss (SNHL) is the most frequent audio-vestibular symptom described, occurring alone or in association with tinnitus and vertigo. The etiopathogenesis of the inner ear disorders related to COVID-19 infection is still poorly understood. The number of reports of COVID-19 infections associated to audio-vestibular disorders is increasing; even if the quality of the studies available is often insufficient, audio-vestibular disorders should be considered as possible manifestations to be included among the symptoms of this infection.

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“…One of the mechanisms driving such thrombosis in COVID-19 is the activation of neutrophils resulting in the formation of NETs [65,66]. Case reports of AAV occurring after diagnosis of COVID-19 have also been reported in the literature [67][68][69][70][71][72]. Although demonstrable vascular thromboses could not be identified in any of these reports, it is known that vascular thromboses might follow diagnosis of AAV.…”

Section: Immunothrombosis In the Context Of Covid-19 And Aav: Is There A Relationship?mentioning

confidence: 99%

Mechanisms of thrombosis in ANCA-associated vasculitis

et al. 2021

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Patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have a two- to threefold greater risk of developing venous as well as arterial thrombotic events. Although such thrombotic events are more commonly seen during phases of active AAV, they are also recognized to occur during AAV in remission. Endothelial injury is a key pathogenic event in AAV. Endothelial injury can be caused by neutrophil activation and release of thrombogenic tissue factor into the circulation. Neutrophil activation further results in the formation of neutrophil extracellular traps (NETs). NETs contribute to thrombosis by expressing tissue factor. NETs have also been detected in cutaneous thrombi from patients with AAV induced by hydralazine. Activated neutrophils in AAV patients release thrombogenic microparticles loaded with tissue factor which further enhances clotting of blood. Antiphospholipid antibodies (APLs) have been detected in up to a third of AAV and might also be induced by drugs such as cocaine adulterated with levamisole and propylthiouracil, which are known to trigger AAV. Such APLs further drive the thrombosis in AAV. Once thrombogenesis occurs, the homeostatic mechanisms resulting in clot dissolution are further impaired in AAV due to anti-plasminogen antibodies. The ongoing pandemic of coronavirus disease 2019 (COVID-19) is associated with endothelial injury and NETosis, mechanisms which are in common with AAV. Reports of new-onset AAV following COVID-19 have been described in the literature, and there could be shared mechanisms driving these processes that require further evaluation.

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COVID-19-induced granulomatosis with polyangiitis

Cited by 30 publications

References 8 publications

COVID-19 from a rheumatology perspective: bibliometric and altmetric analysis

COVID-19 from a rheumatology perspective: bibliometric and altmetric analysis

SARS-CoV-2 (COVID-19) and audio-vestibular disorders

Mechanisms of thrombosis in ANCA-associated vasculitis

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