COVID-19 Induced Cardiovascular Complications and Recent Therapeutic Advances

Chowdhury, Selia; Bappy, Mehedi Hasan; Chowdhury, Samia; Chowdhury, Md. Shahraj; Chowdhury, Nurjahan Shipa

doi:10.24018/ejmed.2021.3.6.1099

Cited by 5 publications

(3 citation statements)

References 60 publications

(49 reference statements)

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“…2 ). The high transmission of Delta Plus could be attributed to the acquisition of K417N spike mutation, which plays a crucial role in the viral entry to the host cells through its interaction with ACE2 receptors [ 63 ].…”

Section: Viral Virulence and Disease Pathogenicity Impaction Of Sars-...mentioning

confidence: 99%

SARS-CoV-2 journey: from alpha variant to omicron and its sub-variants

Hattab,

Amer,

Al-Alami

et al. 2024

Infection

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The COVID-19 pandemic has affected hundreds of millions of individuals and caused more than six million deaths. The prolonged pandemic duration and the continual inter-individual transmissibility have contributed to the emergence of a wide variety of SARS-CoV-2 variants. Genomic surveillance and phylogenetic studies have shown that substantial mutations in crucial supersites of spike glycoprotein modulate the binding affinity of the evolved SARS-COV-2 lineages to ACE2 receptors and modify the binding of spike protein with neutralizing antibodies. The immunological spike mutations have been associated with differential transmissibility, infectivity, and therapeutic efficacy of the vaccines and the immunological therapies among the new variants. This review highlights the diverse genetic mutations assimilated in various SARS-CoV-2 variants. The implications of the acquired mutations related to viral transmission, infectivity, and COVID-19 severity are discussed. This review also addresses the effectiveness of human neutralizing antibodies induced by SARS-CoV-2 infection or immunization and the therapeutic antibodies against the ascended variants.

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Section: Viral Virulence and Disease Pathogenicity Impaction Of Sars-...mentioning

confidence: 99%

SARS-CoV-2 journey: from alpha variant to omicron and its sub-variants

Hattab,

Amer,

Al-Alami

et al. 2024

Infection

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“…There have also been cases of typical stress cardiomyopathy reported, which indicates that both physical and mental stress may play a role in certain cases of cardiovascular consequences of COVID-19 [10]. Right heart failure also appears to be a primary kind of secondary cardiac involvement in the COVID-19 scenario as a direct result of both pulmonary vascular disease (e.g., pulmonary embolism, endothelial dysfunction) and parenchymal lung involvement.…”

Section: Psychological and Physical Strainmentioning

confidence: 99%

Cardiovascular Manifestations of COVID-19: An Update

Roy

2022

JOCCT

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Higher mortality rates are linked to COVID-19 cardiovascular problems. Cardiac damage may result from a variety of factors, including combinations of cytokine storm, myocarditis, extremely high levels of physical and mental stress, ischemic injury, hyper-coagulopathy, right heart strain, and corpulmonale. Prognostic information is provided by echocardiography, c-TN, D-dimer, and NT-proBNP values. There is no particular therapy for COVID-19-related cardiac damage other from percutaneous coronary intervention for STEMI, and care is mostly supportive. It remains to be known if antiviral treatments given early in the course of the illness would stop the severe illness and cardiovascular consequences linked to COVID-19.SAIDs: Non-steroidal Anti-inflammatory Drugs; NO: Nitric Oxide; cGMP: cyclic Guanosine Monophosphate; LDL: Low-density Lipoprotein

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“…Several risk factors are demonstrated from various observational studies and clinical trials. The ongoing COVID-19 pandemic is a challenge for comorbid patients [4]. Comorbidities increase the severity of COVID-19 and thus increase mortality.…”

Section: Introductionmentioning

confidence: 99%

Use of Insulin during the Current Pandemic

Selia¹,

Hasan²,

Shahraj³

et al. 2022

Int Arch Endocrinol Clin Res

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Insulin is one of the greatest medical discoveries of the twentieth century and it continues to be the solitary effective treatment for type 1 diabetes mellitus patients and save millions of lives around the world. In 2021, we have rejoiced 100 years of insulin discovery. The COVID-19 pandemic is currently the most threatening to the global health system, the management of patients with endocrine disorders during this pandemic stance has exceptional challenges. Diabetic patients are prone to more severe illness if infected by COVID-19 and the virus seems to prompt acute demonstration of Diabetes Mellitus (DM) which includes Hyperosmolar Hyperglycemic State (HHS), Diabetic Ketoacidosis (DKA), and serious resistance to insulin. Researchers are currently investigating further details of the impact of COVID-19 on the use of insulin for diabetic patients and developing guidelines for the management of complications related to DM. In this article, we aim to give a comprehensive review of the overall influence of COVID-19 in the use of insulin, its pathophysiological features, its role in the management of patients with hyperglycemia, its clinical outcomes in hospitalized patients, and its contra-indications and side effects based on recent research articles.

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COVID-19 Induced Cardiovascular Complications and Recent Therapeutic Advances

Cited by 5 publications

References 60 publications

SARS-CoV-2 journey: from alpha variant to omicron and its sub-variants

SARS-CoV-2 journey: from alpha variant to omicron and its sub-variants

Cardiovascular Manifestations of COVID-19: An Update

Use of Insulin during the Current Pandemic

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