COVID-19 in Pregnant Women and Their Newborn Infants

Healy, Catherine

doi:10.1001/jamapediatrics.2021.1046

Cited by 18 publications

(17 citation statements)

References 11 publications

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“…The limitation of the clinical design of the study is that we could not compare the GA and MGO values in a control group matched for obesity and the prevalence of diabetes. However, the interpretation of the data that we are supporting here is greatly supported by the large epidemiological studies on COVID-29 syndrome that found a highly significant association of obesity and diabetes with the severity of SARS-CoV-2 infection [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Discussionsupporting

confidence: 75%

“…It is also of interest that MGO-induced RAGEs play a role in platelet activation [ 14 ], which may lead to additional SARS-CoV-2 infection complications. These metabolic processes are also expressed in control pregnant subjects since pregnancy is characterized by para-physiological dyslipidemia and insulin resistance [ 7 , 15 , 16 ]. This could explain why, even in otherwise clinically normal pregnancies, we observed a wide range of GA and MGO values.…”

Section: Discussionmentioning

confidence: 99%

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Glycation-Driven Inflammation: COVID-19 Severity in Pregnant Women and Perinatal Outcomes

Martino

Cappelletti²,

Tondo

et al. 2022

Nutrients

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The link between being pregnant and overweight or obese and the infectivity and virulence of the SARS CoV-2 virus is likely to be caused by SARS-CoV-2 spike protein glycosylation, which may work as a glycan shield. Methylglyoxal (MGO), an important advanced glycation end-product (AGE), and glycated albumin (GA) are the results of poor subclinical glucose metabolism and are indices of oxidative stress. Forty-one consecutive cases of SARS-CoV-2-positive pregnant patients comprising 25% pre-pregnancy overweight women and 25% obese women were recruited. The aim of our study was to compare the blood levels of MGO and GA in pregnant women with asymptomatic and symptomatic SARS-CoV-2 infection with pregnant women without SARS-CoV-2 infection with low risk and uneventful pregnancies and to evaluate the relative perinatal outcomes. The MGO and GA values of the SARS-CoV-2 cases were statistically significantly higher than those of the negative control subjects. In addition, the SARS-CoV-2-positive pregnant patients who suffered of moderate to severe COVID-19 syndrome had higher values of GA than those infected and presenting with mild symptoms or those with asymptomatic infection. Premature delivery and infants of a small size for their gestational age were overrepresented in this cohort, even in mild-asymptomatic patients for whom delivery was not indicated by the COVID-19 syndrome. Moreover, ethnic minorities were overrepresented among the severe cases. The AGE–RAGE oxidative stress axis on the placenta and multiple organs caused by MGO and GA levels, associated with the biological mechanisms of the glycation of the SARS-CoV-2 spike protein, could help to explain the infectivity and virulence of this virus in pregnant patients affected by being overweight or obese or having gestational diabetes, and the increased risk of premature delivery and/or low newborn weight.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Glycation-Driven Inflammation: COVID-19 Severity in Pregnant Women and Perinatal Outcomes

Martino

Cappelletti²,

Tondo

et al. 2022

Nutrients

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“…A ocorrência de restrição de crescimento fetal é reportada entre 7% e 10% dos casos de infecção materna por COVID-19 (Dashraath et al, 2020;Elshafeey et al, 2020). Pesquisas reforçaram ainda que o risco de morbimortalidade perinatal era cerca de duas vezes maior nos recém-nascidos de mães infectadas (Healy, 2021). Quando presentes, os sintomas refletem predominantemente o acometimento do trato respiratório ou a resposta sistêmica à infecção, mas também são observados sintomas gastrointestinais (Brasil, 2021a).…”

Section: Resultsunclassified

Alterações Emocionais Em Gestantes No Período De Pandemia Da Covid-19

FUCHS¹,

SPINDOLA²,

WOICHEKOSKI³

2022

CIÊNCIAS AMBIENTAIS E DA SAÚDE NA ATUALIDADE: Insights Para Alcançar Os Objetivos Para O Desenvolvimento Sustentável

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Os potenciais efeitos da infecção materna e no feto por COVID-19 foram preocupações que atingiram toda a sociedade, essa incerteza se repetiu na psique das gestantes, gerando implicações no seu estado emocional. Então, somando as alterações emocionais da gestação mais o quadro da Pandemia de COVID-19, buscou-se investigar as alterações emocionais nas gestantes durante a pandemia da COVID-19 dos municípios de Mafra, Rio Negrinho e São Bento do Sul/ SC. Participaram 34 gestantes, através da Metodologia Snowball, com aplicação de questionário específico sobre o tema, do GAD-7 e do PHQ-9, aplicados pelo Google Formulários. Como resultados, foram encontrados que 17% das gestantes testaram positivo para COVID-19 e destas 80% já estavam grávidas quando positivaram e sentiram-se com medo e preocupadas com a notícia; 29% das gestantes apresentaram ansiedade leve e 29% apresentaram depressão leve. Para 35% das gestantes essas alterações permaneceram por mais de 6 meses. Percebeu-se então que as gestantes apresentaram medos quanto a contaminação por COVID-19, principalmente em relação à vida delas e do bebê. Estes receios mantiveram-se por quase toda a gestação e isto a longo prazo poderia resultar em dificuldades no parto, pós-parto, vinculação mãe-bebê e no desenvolvimento do bebê.

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“…A multinational study assessing maternal and neonatal morbidity and mortality found that regardless of COVID-19 symptoms, pregnant women were at significantly higher risk of complications and poor pregnancy outcomes, including preeclampsia, eclampsia, preterm birth, intensive care unit admission, and maternal death. Neonatal outcomes were observed to reflect the severity of maternal illness, although lower than maternal risks ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of the COVID-19 Pandemic on Patient Fertility Care

D’Souza

Orellana

Ainsworth

et al. 2022

Journal of Patient Experience

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The effects of the COVID-19 pandemic on the healthcare system have been widespread, with many institutions in the United States pausing elective procedures to redirect resources to critical care. Fertility care and assisted reproductive procedures were classified as elective procedures and similarly paused. We conducted qualitative interviews with patients and/or their partners ( n = 25 female patients; n = 3 male partners) receiving care at a fertility clinic in the Midwest to understand patient appraisal of COVID-19 risk on the resumption of care following a month-long closure of an infertility clinic, and patient agreement with the clinic closure. Interview transcripts were thematically analyzed from a grounded theory approach. Study participants reported an increased sense of urgency due to the delay in fertility procedures. This urgency often superseded concerns of potential COVID-19 infection, motivating patients to continue fertility treatment during a pandemic. In hindsight, some participants did not agree with the clinic's closure and treatment cessation, feeling that these steps negatively interrupted time-sensitive reproductive goals. Patient responses highlight the need for additional resources to support decision-making during times of crisis. Triaging patients based on time-sensitivity of treatment instead of a total shutdown respects patient autonomy for continuing treatment amidst uncertain COVID-19-impact.

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COVID-19 in Pregnant Women and Their Newborn Infants

Cited by 18 publications

References 11 publications

Glycation-Driven Inflammation: COVID-19 Severity in Pregnant Women and Perinatal Outcomes

Glycation-Driven Inflammation: COVID-19 Severity in Pregnant Women and Perinatal Outcomes

Alterações Emocionais Em Gestantes No Período De Pandemia Da Covid-19

Impact of the COVID-19 Pandemic on Patient Fertility Care

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