COVID-19 in hospitalized adult patients with sickle cell disease: A 2020 US cohort using Cerner Real-World Data^™ (CRWD)

Abstract

We used Cerner Real-World Data™, representing hospital admission records from 2020, to examine patients with co-occurring sickle cell disease and COVID-19 by discharge disposition grouped as death/hospice versus transfers to other facilities, returned home, or left against medical advice. Among the death/hospice group, we found older age and higher rates of congestive heart failure and diabetes. There were also significant differences in tachypnea, mechanical ventilation, minimum O2 saturation, and length of stay with higher rates in the death/hospice group. Awareness of such factors and associated mortality risks for this population may aid in patient care.

Advancing regulatory science through real-world data and real-world evidence

“…Use of RWD to inform trial designs and generate RWE to evaluate safety and efficacy [1][2][3][4][5][6][7][8][9][10][11][12] Currently, most of the patient-derived RWD used in biomedical research resides in Electronic Health Records (EHRs). Even though their development was not intended for research purposes, the large volume of information, data richness, continuum of care data collection, and ability to be linked and integrated with additional data from medical encounters such as claims data, imaging, and laboratory information can provide a more comprehensive view of an individual and their health journey.…”