COVID-19 in congenital heart disease (COaCHeD) study

Chivers, Sian; Cleary, Aoife; Knowles, Rachel L; Babu‐Narayan, Sonya V.; Simpson, John; Nashat, Heba; Dimopoulos, Konstantinos; Wilson, Dirk G.; Prica, Milos; Anthony, James C.; Clift, Paul; Jowett, Victoria; Jenkins, Peter; Khodaghalian, Bernadette; Jones, Caroline B.; Hardiman, Antonia; Head, Catherine; Miller, Owen; Chung, Natali; Mahmood, Umar; Bu’Lock, Frances; Ramcharan, Tristan; Chikermane, Ashish; Shortland, Jennifer; Tometzki, Andrew; Crossland, David S; Reinhardt, Zdenka; Lewis, Clive; Rittey, L; Hares, Dominic; Panagiotopoulou, Olga; Smith, Ben; L, Muhammad Najih; Bharucha, Tara; Daubeney, Piers E.F.

doi:10.1136/openhrt-2023-002356

Cited by 2 publications

References 13 publications

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Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis

Aparicio,

Willis,

Nakamura

et al. 2024

Preprint

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Background: Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define the clinical characteristics and comorbidities associated with critical COVID-19 in children and adolescents. Methods: Two independent reviewers screened the literature (Medline and EMBASE) for studies published through August 2023 that reported outcome data on patients aged 21 years or younger with COVID-19. Critical disease was defined as an invasive mechanical ventilation requirement, intensive care unit admission, or death. Random effects models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (CI), and heterogeneity was explored through subgroup analyses. Results: Among 10,178 articles, 136 studies met the inclusion criteria for review. Data from 70 studies, which collectively examined 172,165 children and adolescents with COVID-19, were pooled for meta-analysis. In previously healthy children, the absolute risk of critical disease from COVID-19 was 4% (95% CI, 1%-10%). Compared with no comorbidities, the pooled OR for critical disease was 3.95 (95% CI, 2.78-5.63) for presence of one comorbidity and 9.51 (95% CI, 5.62-16.06) for ≥2 comorbidities. Key risk factors included cardiovascular and neurological disorders, chronic pulmonary conditions (excluding asthma), diabetes, obesity, and immunocompromise, all with statistically significant ORs >2.00. Conclusions: While the absolute risk for critical COVID-19 in children and adolescents without underlying health conditions is relatively low, the presence of one or more comorbidities was associated with markedly increased risk. These findings support the importance of risk stratification in tailoring pediatric COVID-19 management.

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Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis

Aparicio,

Willis,

Nakamura

et al. 2024

Preprint

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Impact of COVID-19 Infections among Unvaccinated Patients with Congenital Heart Disease: Results of a Nationwide Analysis in the First Phase of the Pandemic

Fischer,

Hellmann,

Diller

et al. 2024

JCM

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Background: The outcome data and predictors for mortality among patients with congenital heart disease (CHD) affected by COVID-19 are limited. A more detailed understanding may aid in implementing targeted prevention measures in potential future pandemic events. Methods: Based on nationwide administrative health insurance data, all the recorded in-hospital cases of patients with CHD with COVID-19 in 2020 were analyzed. The demographics, treatment details, as well as 30-day mortality rate were assessed. The associations of the patients’ characteristics with death were assessed using multivariable logistic regression analysis. Results: Overall, 403 patients with CHD were treated in- hospital for COVID-19 in 2020. Of these, 338 patients presented with virus detection but no pneumonia whilst, 65 patients suffered from associated pneumonia. The cohort of patients with pneumonia was older (p = 0.04) and presented with more cardiovascular comorbidities such as diabetes mellitus (p = 0.08), although this parameter did not reach a statistically significant difference. The 30-day mortality rate was associated with highly complex CHD (odds ratio (OR) 7.81, p = 0.04) and advanced age (OR 2.99 per 10 years, p = 0.03). No child died of COVID-related pneumonia in our dataset. Conclusions: COVID-19 infection with associated pneumonia chiefly affected the older patients with CHD. Age and the complexity of CHD were identified as additional predictors of mortality. These aspects might be helpful to retrospectively audit the recommendations and guide health politics during future pandemic events.

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COVID-19 in congenital heart disease (COaCHeD) study

Cited by 2 publications

References 13 publications

Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis

Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis

Impact of COVID-19 Infections among Unvaccinated Patients with Congenital Heart Disease: Results of a Nationwide Analysis in the First Phase of the Pandemic

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