COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality

Martínez-Murillo, Carlos; Peñafiel, Christian Ramos; Basurto, Lourdes; Balcázar-Hernández, Lourdes; Pellón, Karen; López, Eder Flores; Gómez, Beatriz Li; Ledesma, Mercedes Estefania; Tapia, R; Maldonado, Elizabeth Madera; Rosales, Monica Bejarano; Lampon, Gilberto Barranco; Zazueta, Juan

doi:10.1002/edm2.279

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Using the pre-specified, literature-based threshold of 7.8 mmol/l [13], the prevalence of high blood glucose levels was high among COVID-19 patients. This high prevalence is similar to that reported in other studies even though the cut-off used to define high blood glucose levels was not uniform [15][16][17]. In addition, the mean pre-hospital blood glucose level in our study was 8.8mmol/l, a value consistent with prior studies [15][16][17].…”

Section: Discussionsupporting

confidence: 91%

“…This high prevalence is similar to that reported in other studies even though the cut-off used to define high blood glucose levels was not uniform [15][16][17]. In addition, the mean pre-hospital blood glucose level in our study was 8.8mmol/l, a value consistent with prior studies [15][16][17]. Patients with high PBG levels were more likely to be admitted to the ICU, but there was no statistically significant difference when all acute medical units were considered jointly.…”

Section: Discussionsupporting

confidence: 90%

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Association Between Prehospital Blood Glucose Levels and Outcomes in Patients With COVID-19 Infection: A Retrospective Cohort Study

Fehlmann

Suppan

Gaudet-Blavignac

et al. 2023

Exp Clin Endocrinol Diabetes

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Background: Hyperglycaemia is associated with worse outcomes in many settings. However, the association between dysglycaemia and adverse outcomes remains debated in COVID-19 patients. The objective of this study was to determine the association between prehospital blood glucose levels and acute medical unit (intensive care unit or high dependency unit) admission and mortality among COVID-19 infected patients. Methods: This was a monocentric retrospective cohort study, based on patients taken care by the prehospital medical mobile unit from a Swiss university hospital between March 2020 and April 2021 All adult patients in whom a COVID-19 infection was confirmed or suspected during the study period a were included. Data were obtained from the prehospital medical files. The main exposure was prehospital blood glucose level. A 7.8mmol/l cut-off was used to define high blood glucose level. Restricted cubic splines were also used to analyse the exposure as a continuous variable. The primary endpoint was acute medical unit admission, and secondary endpoints were and 7-day and 30-day mortality. Multivariable logistic regressions were performed to compute odds ratios. Results: A total of 276 patients were included. The mean prehospital blood glucose level was 8.8mmol/l, and 123 patients presented high blood glucose levels. The overall acute medical unit admission rate was 31.2%, with no statistically significant difference according to prehospital blood glucose levels. The mortality rate was 13.8% at seven days and 25% at 30 days. The mortality rate at 30 days was higher in patients with high prehospital blood glucose levels, with an adjusted odds-ratio of 2.5 (1.3 – 4.8). Conclusions: In patients with acute COVID-19 infection, prehospital blood glucose levels do not seem to be associated with acute medical unit admission. An increased risk of 30-day mortality was however found in COVID-19 patients who presented high prehospital blood glucose levels.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Association Between Prehospital Blood Glucose Levels and Outcomes in Patients With COVID-19 Infection: A Retrospective Cohort Study

Fehlmann

Suppan

Gaudet-Blavignac

et al. 2023

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

show abstract

“…In details, in the general population, risk factors for severe COVID-19 disease are age equal or older than 65 years [odds ratio (OR): 4.14]; chronic respiratory conditions (OR: 2.34); chronic kidney disease (OR: 2.96); diabetes (OR: 2.38); obesity (OR: 2.42), cardiovascular disease (OR: 3.2) [3,4]. Chronic respiratory conditions are also risk factors for hospitalization [5].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 in complex common variable immunodeficiency patients affected by lung diseases

Milito

Soccodato

Auria

et al. 2021

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewIn the general population, the risk of severe COVID-19 is associated with old age, male sex, hypertension, obesity and chronic diseases. Chronic lung diseases are listed as additional risk factors for hospitalization and ICU admission. The purpose of this review is to define whether chronic lung diseases, such as bronchiectasis and interstitial diseases, represent a risk for a severe SARS-CoV-2 infection in patients affected by common variable immunodeficiency (CVID), the most common symptomatic primary antibody defect. Recent findingsCVID patients with SARS-CoV-2 infection have been reported since the beginning of the pandemic with a wide range of clinical presentations ranging from asymptomatic to mild/moderate and severe COVID-19. The meta-analysis of 88 CVID cases described in large cohorts and case reports demonstrated that CVID patients with chronic lung involvement have an increased risk for severe COVID-19 in comparison to CVID without lung diseases (50 vs. 28%, relative risk 1.75, 95% confidence interval 1.04-2.92, P ¼ 0.043). Differently from the general population, age and metabolic comorbidities did not represent a risk factor for severe course in this patient's population.

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Thrombotic risk assessed by PAI-1 in patients with COVID-19: The influence of hyperglycemia and diabetes mellitus

Basurto,

Manuel-Apolinar,

Robledo

et al. 2024

Clínica e Investigación en Arteriosclerosis (English Edition)

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COVID‐19 in a country with a very high prevalence of diabetes: The impact of admission hyperglycaemia on mortality

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 7 publications

References 34 publications

Association Between Prehospital Blood Glucose Levels and Outcomes in Patients With COVID-19 Infection: A Retrospective Cohort Study

Association Between Prehospital Blood Glucose Levels and Outcomes in Patients With COVID-19 Infection: A Retrospective Cohort Study

COVID-19 in complex common variable immunodeficiency patients affected by lung diseases

Thrombotic risk assessed by PAI-1 in patients with COVID-19: The influence of hyperglycemia and diabetes mellitus

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