COVID-19 in a Child with Primary Antibody Deficiency

Ahanchian, Hamid; moazzen, nasrin; Aelami, Mohammad Hasan; Faroughi, Majid Sezavar Dokht; Haghi, Nasrin Sadat Motevalli; Khalighi, Negar; Khoshkhui, maryam; Rezaei, Nazila

doi:10.22541/au.159986862.23157416

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The restricted knowledge about the immunopathology of SARS-CoV-2 infection for IEI patients raised the question about the clinical impact of COVID-19 and the risk involved for these patients [27]. As already mentioned, several case reports were previously published [7][8][9][10][11][12][13]15], as well as two larger series: 94 IEI patients in Meyts et al study, from ESID [14], and 60 IEI patients and 33 secondary immunode cient patients from Shields et al study [16], in the UK.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Outcome of SARS-CoV-2 Infection in 121 Patients With Inborn Errors of Immunity: A Cross-sectional Study

Goudouris

Pinto‐Mariz

Mendonça

et al. 2021

Preprint

View full text Add to dashboard Cite

Purpose: There is still scarce data on SARS-CoV-2 infection in patients with Inborn Errors of Immunity (IEI) and many questions. We aimed to describe the clinical outcome of SARS-CoV-2 infection in Brazilian IEI patients and to identify factors influencing the outcome of infection.Methods: We did a cross-sectional, multicenter study that included patients of any age affected by IEI and SARS-CoV-2 infection. The variables studied were sex, age, type of IEI, comorbidities (number and type), treatment in use for IEI, clinical manifestations and severity of SARS-CoV-2 infection. Results: 121 patients were included: 55.4% female, ages from six months to 74 yo (median age = 25.1 yo). Most patients had predominantly antibody deficiency (n=53). The infection presented mostly as asymptomatic (n=21) and mild (n=66), and one child had multisystem inflammatory syndrome (MIS-C). We could not observe sex related susceptibility and observed a weak correlation between age and severity of infection. The number of comorbidities was higher in severe cases, particularly bronchiectasis and cardiopathy. There were no severe cases in hereditary angioedema patients. Six patients aged 2 to 74 years died, three of them with antibody deficiency. Conclusion: The outcome was mild in most patients, but the Case Fatality Ratio was higher than in the general population. Patients with complement deficiencies had milder COVID-19. However, the type of IEI was not a determining factor for severity. The severity of SARS-CoV-2 infection seems to be more related to older age, higher number of comorbidities and type of comorbidities (bronchiectasis and cardiopathy).

show abstract

Section: Discussionmentioning

confidence: 98%

“…Case reports and case series have been published about the clinical outcome of patients with IEI [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

mentioning

confidence: 99%