COVID-19 in 17 Italian Pediatric Emergency Departments

Parri, Niccolò; Lenge, Matteo; Cantoni, Barbara; Arrighini, A.; Romanengo, Marta; Urbino, Antonio; Dalt, Liviana Da; Verdoni, Lucio; Giacchero, Roberta; Lanari, Marcello; Musolino, Anna Maria; Biban, Paolo; Fauci, Giovanna La; Pozzi, Chiara; Buonsenso, Danilo; Chiossi, M.; Agostiniani, Rino; Plebani, A; Zampogna, Stefania; Barbieri, Maria Antonietta; Masi, Salvatore; Agostoni, Carlo; Masi, Stefano

doi:10.1542/peds.2020-1235

Cited by 77 publications

(80 citation statements)

References 20 publications

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“…Children have been mostly overlooked during this pandemic, since the clinical course of COVID-19 in this group is much milder than in adults (4). However, there is an increasing evidence that restrictive measures aimed at limiting the pandemic are having a significant impact on child’s mental health (5).…”

Section: Discussionmentioning

confidence: 99%

Preliminary Evidence on Long COVID in children

Buonsenso

Munblit

Rose

et al. 2021

Preprint

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There is increasing evidence that adult patients diagnosed with acute COVID-19 suffer from Long COVID initially described in Italy.To date, data on Long COVID in children are lacking.We assessed persistent symptoms in pediatric patients previously diagnosed with COVID-19. More than a half reported at least one persisting symptom even after 120 days since COVID-19, with 42.6% being impaired by these symptoms during daily activities. Symptoms like fatigue, muscle and joint pain, headache, insomnia, respiratory problems and palpitations were particularly frequent, as also described in adults.The evidence that COVID-19 can have long-term impact children as well, including those with asymptomatic/paucisymptomatic COVID-19, highlight the need for pediatricians, mental health experts and policy makers of implementing measures to reduce impact of the pandemic on child’s health.

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Section: Discussionmentioning

confidence: 99%

Preliminary Evidence on Long COVID in children

Buonsenso

Munblit

Rose

et al. 2021

Preprint

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“…However, if such a differences between sexes is present in the pediatric population has never been analyzed yet. Major pediatric papers mainly focused age as a risk factors of disease severity but, to our knowledge, no sub-analyses assessing sex have been described (9)(10)(11)(12)(13)(14)(15). Since sex-hormones or specific habits (alcohol, type-2 diabetes, cardiovascular disease) are less pronounced in the pediatric population, in particular in infants and young children, such an analyses can provide indirect evidence of influence of hormones on COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Influence of sex on disease severity in children with COVID-19 and Multisystem Inflammatory Syndrome in Latin America

Brizuela¹,

Lenzi

Ulloa‐Gutiérrez

et al. 2021

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Data from adult studies how that COVID-19 is more severe in men than women. However, no data are available for the pediatric population. For this reason, we performed this study aiming to understand if sex influenced disease severity and outcomes in a large cohort of latin-american children with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C). We found that a higher percentage of male children developed MIS-C (8.9% vs 5% in females) and died (1.2% and 0.4% in females), although on multivariate adjusted analyses the only statistically significant difference was found in need of hospitalization, with females less frequently admitted compared with boys (25.6% vs 35.4%). This data are preliminary and need further independent studies to better assess the role of sex.

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“…Initial data from the Chinese Center for Disease Control and Prevention which evaluated case series of 2143 pediatric patients with COVID-19 showed that although the majority of cases had mild or no symptoms, severe and critical cases were present in 10.6%, and 7.3%, for the age groups <1 and 1-4 years [26], and a large US study revealed that children may be a potential source of contagion in the SARS-CoV-2 pandemic even in the absence of symptoms [27]. Two Italian descriptive studies during the rst months of the pandemic reported respectively that 8.5% had moderate disease, 8.5% had a severe disease and 6.9% had a critical presentation [28] and that 43% had been hospitalized, con rming that, although severe cases are rare, children may represent a source of viral transmission [29].…”

Section: Discussionmentioning

confidence: 98%

Impact of novel Coronavirus Disease-19 (COVID-19) pandemic in Italian pediatric emergency departments: a national survey

Talarico

Pinto²,

Marseglia

et al. 2021

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BACKGROUND: Coronavirus Disease-19 (COVID-19) has rapidly become a pandemic emergency, distressing health systems in each affected country. Preparation strategies for managing this pandemic have been keys to face the COVID-19 surge all over the world and all levels of care. MATERIAL AND METHODS: During the epidemic, the Italian society of pediatric emergency-urgency (SIMEUP) promoted a national survey aiming to evaluate preparedness and response of pediatric emergency departments (PED) critical in ensuring optimal management of COVID-19 cases. RESULTS: Our results suggest that Italian PED have promptly set a proactive approach to the present emergency. 98.9% of the hospitals have defined special pathways and assistive protocols concerning the management of pediatric COVID-19 cases. The highest percentage of application of the measures for preventive and protective for COVID-19 concerned the use of personal protective equipments. CONCLUSIONS: Results show that the following measures for pediatric patients, admitted in PED, have been promptly implemented throughout the whole country: eg. use of protective devices, pre-triage of patients accessing the hospital. Despite COVID-19 being a new threat, we have shown that by developing an easy-to-follow decision algorithm and clear plans for the interventional platform teams, we can ensure optimal health care workers and patients’ safety.

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COVID-19 in 17 Italian Pediatric Emergency Departments

Cited by 77 publications

References 20 publications

Preliminary Evidence on Long COVID in children

Preliminary Evidence on Long COVID in children

Influence of sex on disease severity in children with COVID-19 and Multisystem Inflammatory Syndrome in Latin America

Impact of novel Coronavirus Disease-19 (COVID-19) pandemic in Italian pediatric emergency departments: a national survey

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