Covid-19: Government was too slow to respond to ventilator shortages, say MPs

O’Dowd, Adrian

doi:10.1136/bmj.m4594

Cited by 5 publications

(4 citation statements)

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“…14 While production ramped up, the market was still under a lot of pressure, and prices increased exponentially. 15 Financial powers decided who got the scarce medical equipment. We could see the same pattern in vaccine distribution.…”

Section: The Failure Of Nationalism and Free Market Bargainingmentioning

confidence: 99%

Ethical Obligations of Global Justice in the Midst of Global Pandemics

Hicks

Gurtler²

2023

Ethica

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This paper considers the obligation higher income countries have to lower and middle income countries during a global pandemic. Further considers which reforms are needed to the global supply-chain of medical resources. The short-comings in distribution and medical infrastructure have exacerbated the health crisis in developing countries. Global justice demands radical redistribution of medical resources in order to prevent mass casualties. This is argued first by highlighting that the COVID-19 pandemic should be acknowledged as an issue of global justice, secondly, higher income countries ought to account for distribution inequity as a matter of rectifying past injustices, and thirdly argue for reform in distribution while considering the vaccine rollout as a prime example. We aim to show how the differences from country to country in response capabilities are a result of the economic foundation colonialism established and a direct result of cyclical poverty, which wealthy countries perpetuate to this day.

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Section: The Failure Of Nationalism and Free Market Bargainingmentioning

confidence: 99%

Ethical Obligations of Global Justice in the Midst of Global Pandemics

Hicks

Gurtler²

2023

Ethica

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“…Symptomatic therapy to alleviate symptoms in clinical practice mainly includes reducing the temperature of patients with a high fever, providing ventilators to critically ill patients with severe respiratory failure, using plasma exchange 36 technologies to remove excessive hazardous substances in the circulatory system and prescribing herbal medicine to promote recovery 37 , 38 . However, these therapies do not completely cure COVID-19, and some of them, such as ventilators, NAbs and plasmapheresis, are very expensive and in short supply 39 , 40 . Therefore, new therapies for COVID-19 are urgently being sought.…”

Section: Introductionmentioning

confidence: 99%

Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19

Liu

Han

Jin

et al. 2023

Acta Pharmaceutica Sinica B

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“…The pandemic has had profound impacts on society and economy due to containment measures, including travel restrictions, school closures, and even complete lock-downs [ 4 ]. It also has shed light on the importance of having access to rapid and accurate diagnostics; however, massive diagnostic testing led to shortages in several reagents and plasticware needed for performing RT-PCR for SARS-CoV-2 detection [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Genes Involved in miRNA Biogenesis Are Not Downregulated in SARS-CoV-2 Infection

Garnier

Sané²,

Massara

et al. 2023

Viruses

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miRNAs, small non-coding RNAs that regulate gene expression, are involved in various pathological processes, including viral infections. Virus infections may interfere with the miRNA pathway through the inhibition of genes involved in miRNA biogenesis. A reduction in the number and the levels of miRNAs expressed in nasopharyngeal swabs of patients with severe COVID-19 was lately observed by us, pointing towards the potential of miRNAs as possible diagnostic or prognostic biomarkers for predicting outcomes among patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The objective of the present study was to investigate whether SARS-CoV-2 infection influences the expression levels of messenger RNAs (mRNAs) of key genes involved in miRNA biogenesis. mRNA levels of AGO2, DICER1, DGCR8, DROSHA, and Exportin-5 (XPO5) were measured by quantitative reverse-transcription polymerase chain reaction (RT-qPCR) in nasopharyngeal swab specimens from patients with COVID-19 and controls, as well as in cells infected with SARS-CoV-2 in vitro. Our data showed that the mRNA expression levels of AGO2, DICER1, DGCR8, DROSHA, and XPO5 were not significantly different in patients with severe COVID-19 when compared to patients with non-severe COVID-19 and controls. Similarly, the mRNA expression of these genes was not affected by SARS-CoV-2 infection in NHBE and Calu-3 cells. However, in Vero E6 cells, AGO2, DICER1, DGCR8, and XPO5 mRNA levels were slightly upregulated 24 h after infection with SARS-CoV-2. In conclusion, we did not find evidence for downregulation of mRNA levels of miRNA biogenesis genes during SARS-CoV-2 infection, neither ex vivo nor in vitro.

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Covid-19: Government was too slow to respond to ventilator shortages, say MPs

Cited by 5 publications

References 0 publications

Ethical Obligations of Global Justice in the Midst of Global Pandemics

Ethical Obligations of Global Justice in the Midst of Global Pandemics

Regulating the microenvironment with nanomaterials: Potential strategies to ameliorate COVID-19

Genes Involved in miRNA Biogenesis Are Not Downregulated in SARS-CoV-2 Infection

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