COVID-19 Enfeksiyonu Sonrası Femur Başının Bilateral Avasküler Nekrozu: Bir Olgu Sunumu

UYSAL, Alper; UYSAL, Merve ERDEM

doi:10.29058/mjwbs.1054040

Cited by 3 publications

(12 citation statements)

References 12 publications

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“…Therefore, in our case report, the time interval between corticosteroid consumption and AVN event is longer than other studies. Proposed mechanisms for steroid induced AVN including vascular endothelial damage, microvascular thrombosis, intramedullary adipogenesis, fat embolism, increased osteocyte death, decreased osteoblast differentiation, and prolongation of osteoclast life span 13,33 …”

Section: Discussionmentioning

confidence: 99%

“…Proposed mechanisms for steroid induced AVN including vascular endothelial damage, microvascular thrombosis, intramedullary adipogenesis, fat embolism, increased osteocyte death, decreased osteoblast differentiation, and prolongation of osteoclast life span. 13,33 COVID-19 leads to multi-system dysfunction. This virus results in endothelial injury, involving immune activation, pro-thrombotic milieu, and renin-angiotensin-aldosterone system dysregulation.…”

Section: F I G U R Ementioning

confidence: 99%

“…34 After the COVID-19 pandemic, there are some case reports and case series of AVN related to COVID-19. [11][12][13][14][15][16][17][18][19][20][21] In COVID-19 patients, multiple mechanisms, such as endothelial dysfunction, clot formation, and corticosteroid consumption, may occur simultaneously, which all lead to bone infarct or osteonecrosis. The prevalence of AVN related to COVID-19 was reported to be around 0.07%.…”

Section: F I G U R Ementioning

confidence: 99%

“…13,21 It seems that steroid induced AVN in COVID-19 occurs earlier and with lower doses of steroid compared to AVN in non-COVID-19 patients. 13,[35][36][37] However, in our case, osteonecrosis occurred late (20 months after COVID-19).…”

Section: F I G U R Ementioning

confidence: 99%

“…It seems that in COVID‐19 patients, multiple mechanisms, such as endothelial dysfunction, clot formation, and corticosteroid consumption, may occur simultaneously, which all lead to bone infarct or osteonecrosis. There are some case reports of AVN related to COVID‐19 around the world 11–21 . Data have shown that AVN in COVID‐19 develops in shorter time compared with this pathology in patients without COVID‐19 22 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Who is the convict; COVID‐19 or corticosteroid? Late onset avascular necrosis of hips after COVID‐19. A case report with literature review

et al. 2023

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AimAvascular necrosis (AVN) or osteonecrosis is characterized by death of bone tissue due to endothelial damage and vascular abnormality. Coronavirus can induce endothelial damage and abnormal blood clotting, so that COVID‐19 is known as a vascular disease. We aim to evaluate the relationship between AVN and COVID‐19.CaseHere we present a 39‐year old man with severe COVID‐19 and corticosteroid consumption who developed late onset AVN of both hips 20 month after COVID‐19.ConclusionAn awareness of the possible osteonecrosis for all physicians dealing with patients with musculoskeletal problems following COVID‐19 is necessary.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Who is the convict; COVID‐19 or corticosteroid? Late onset avascular necrosis of hips after COVID‐19. A case report with literature review

et al. 2023

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A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis

Sakellariou,

Argyropoulou,

Karampinas

et al. 2024

Diagnostics

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Background: The COVID-19 pandemic has presented numerous challenges to the global healthcare system and emerging evidence suggests a potential link between COVID-19 treatment, specifically steroid therapy, and the development of avascular necrosis (AVN) of the hip. This review aims to provide a comprehensive overview of recent studies and case reports investigating the relationship between COVID-19, corticosteroid therapy, and the development of AVN. Understanding the nuances of AVN in the context of COVID-19 is crucial for healthcare professionals to navigate treatment decisions and mitigate potential complications. Materials and Methods: The Preferred Reporting Items for Systematic Reviews and a Meta-Analysis (PRISMA) were used in the systematic review until 1 September 2023. The full texts of the remaining twenty-three (n = 23) articles were independently reviewed by the authors of this review. Conclusions: The association between steroid therapy for COVID-19 and the development of hip AVN is a noteworthy concern even though no relationship is evident between the duration of treatment, cumulative dosage of medication, maximum daily dosage received, and presence of AVN. Further research with larger cohorts and long-term follow up is needed to better understand the causative relationship and optimal management strategies for hip AVN in the context of COVID-19 and steroid therapy.

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Bilateral avascular necrosis of femoral head following COVID-19 infection: Case series

Shershah,

Chandrashekar,

Ramanand

et al. 2023

Sanamed

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Introduction: Despite having a substantial impact on survivors' mobility and leading to morbidity, musculoskeletal involvement was the post-COVID-19 infection sequelae area that received the least attention in the literature. Reviewing the COVID-19 histories of patients who visited a tertiary health center, the research is aimed at finding an association between COVID-19 infection and avascular femoral head necrosis, a condition brought on by insufficient blood flow. Avascular necrosis of the femoral head is a condition characterized by a restricted range of motion, pain, and disturbance of gait. It is brought on by insufficient blood flow. Case reports: We discussed several examples in which COVID-19 caused individuals to develop bilateral femoral head necrosis. When COVID-19 infection is the only factor present, and corticosteroids are used to treat it, avascular necrosis of the femoral head may become more prevalent. Detecting avascular necrosis of the femoral head in its early stages, hip MRI might reduce the patient's disability and need for continuous treatment. Conclusion: Early identification and treatment of AVN patients reduce the need for surgery and the chance of disabilities.

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COVID-19 Enfeksiyonu Sonrası Femur Başının Bilateral Avasküler Nekrozu: Bir Olgu Sunumu

Cited by 3 publications

References 12 publications

Who is the convict; COVID‐19 or corticosteroid? Late onset avascular necrosis of hips after COVID‐19. A case report with literature review

Who is the convict; COVID‐19 or corticosteroid? Late onset avascular necrosis of hips after COVID‐19. A case report with literature review

A Comprehensive Review of COVID-19-Infection- and Steroid-Treatment-Associated Bone Avascular Necrosis: A Multi-Study Analysis

Bilateral avascular necrosis of femoral head following COVID-19 infection: Case series

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