COVID-19 effects on the kidney

Amann, Kerstin; Wiech, Thorsten; Singh, Jeeshan; Vonbrunn, Eva; Knöll, Antje; Hermann, M.; Büttner‐Herold, Maike; Daniel, Christel; Hartmann, Arndt

doi:10.1007/s00292-020-00900-x

Cited by 16 publications

(17 citation statements)

References 38 publications

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“…Furthermore, autopsy data alone may not be appropriate to derive this conclusion. The renal pathophysiology in COVID-19 requires further clarification, as also stated by other authors [46,50]. The liver, an organ known for viral tropism and some associated characteristic histopathological patterns (e.g., CMV, EBV, and hepatitis), in this study cohort did not show any specific histological changes.…”

Section: Detection Of Sars-cov-2 and Correlation With Histological Changessupporting

confidence: 67%

“…Varga et al first proposed endothelialitis as a cause of this increased coagulation propensity [13]. Renal damage has also been described in detail [14]. However, the findings related to the central nervous system (CNS) have been contradictory and do not yet provide sufficient evidence for direct brain damage by SARS-Cov2, except for involvement in systemic coagulation.…”

Section: Introductionmentioning

confidence: 99%

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Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approach

et al. 2021

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Background COVID-19 is only partly understood, and the level of evidence available in terms of pathophysiology, epidemiology, therapy, and long-term outcome remains limited. During the early phase of the pandemic, it was necessary to effectively investigate all aspects of this new disease. Autopsy can be a valuable procedure to investigate the internal organs with special techniques to obtain information on the disease, especially the distribution and type of organ involvement. Methods During the first wave of COVID-19 in Germany, autopsies of 19 deceased patients were performed. Besides gross examination, the organs were analyzed with standard histology and polymerase-chain-reaction for SARS-CoV-2. Polymerase chain reaction positive localizations were further analyzed with immunohistochemistry and RNA-in situ hybridization for SARS-CoV-2. Results Eighteen of 19 patients were found to have died due to COVID-19. Clinically relevant histological changes were only observed in the lungs. Diffuse alveolar damage in considerably different degrees was noted in 18 cases. Other organs, including the central nervous system, did not show specific micromorphological alterations. In terms of SARS-CoV-2 detection, the focus remains on the upper airways and lungs. This is true for both the number of positive samples and the viral load. A highly significant inverse correlation between the stage of diffuse alveolar damage and viral load was found on a case and a sample basis. Mediastinal lymph nodes and fat were also affected by the virus at high frequencies. By contrast, other organs rarely exhibited a viral infection. Moderate to strong correlations between the methods for detecting SARS-CoV-2 were observed for the lungs and for other organs. Conclusions The lung is the most affected organ in gross examination, histology and polymerase chain reaction. SARS-CoV-2 detection in other organs did not reveal relevant or specific histological changes. Moreover, we did not find CNS involvement.

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Section: Detection Of Sars-cov-2 and Correlation With Histological Changessupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approach

et al. 2021

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“…У 3-4% больных развитие ОПН потребовало проведения гемодиализа. Исходом данной патологии может стать прогрессирующий нефросклероз с развитием или прогрессированием хронической болезни почек (ХБП) [15][16][17].…”

Section: последствия инфекции Sars-cov-2unclassified

“Post-COVID syndrome”: The focus is on musculoskeletal pain

Каратеев¹,

Амирджанова²,

Насонов

et al. 2021

Naučno-praktičeskaâ revmatologiâ

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Combating the consequences of COVID-19, a disease caused by the new coronavirus infection SARS-CoV-2, is a serious and very urgent task facing modern medicine. COVID-19 often has a severe course and is accompanied by multiple organ damage, systemic immune inflammation, coagulopathy, neuroendocrine and metabolic disorders. Even with a relatively favorable course, the consequences of SARS-CoV-2 infection can be degenerative changes in many organs (pulmonary fibrosis, cardiosclerosis), various functional and psychoemotional disorders. As a result, in 10–50% of patients, various unpleasant symptoms persist for a long time after the acute manifestations of COVID-19 subside and the virus is eliminated. This pathology is referred to as “post-COVID syndrome” (PCS). The main elements of PCS are chronic pain, fatigue, and psychoemotional problems. Functional disorders, autoimmune processes, and severe psychological distress after COVID-19 can cause the development and exacerbation of diseases characterized by chronic pain and fatigue, such as fibromyalgia and chronic fatigue syndrome. Therapy and prevention of PCS include correction of functional disorders, pain control, and consistent physical, psychological, and social rehabilitation.

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“…По данным серии исследований, клини чески значимую ренальную патологию отмечали у 20% больных, госпитализированных по поводу COVID-19, а 3-4% пациентов из-за развития острой почечной недостаточности потребовался гемодиализ. Исходом данной патологии может стать прогрессирующий нефросклероз и дальнейшее развитие или прогрессирование хронической болезни почек [9][10][11].…”

Section: патогенез постковидного синдромаunclassified

Chronic Musculoskeletal Pain Associated with a Previous SARS-CoV-2 Infection

Каратеев¹,

Scientific²,

Лила³

et al. 2021

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Objective of the Review: To describe the problem of chronic musculoskeletal pain associated with a previous SARS-CoV-2 infection. Key Points. COVID-19 is a disease caused by the novel coronavirus infection SARS-CoV-2, characterised by multiple organ damage, systemic immune inflammation, coagulopathy, and serious neuroendocrine and metabolic disorders. The consequences of COVID-19, even with a relatively favourable course of this disease, can be degenerative changes in many organs (primarily, diffuse fibrosis), various functional and mental disorders. Therefore, in some patients (10% to 50%, depending on the severity of the course of COVID-19), various symptoms of the disease persist for a long time after the acute manifestations of the infection subside. This condition has been called “post-COVID syndrome” (PCS), or “long-term COVID-19”. One of the main manifestations of PCS is musculoskeletal pain, weakness and fatigue. COVID-19-induced damage to the musculoskeletal and nervous systems can contribute to the exacerbation of diseases characterised by chronic pain. PCS management should be aimed at correcting functional disorders, pain control, and active rehabilitation of patients. Conclusion. Chronic pain is one of PCS manifestations that requires special attention, timely diagnosis, and comprehensive individual therapy. Keywords: COVID-19, post-COVID syndrome, musculoskeletal pain.

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COVID-19 effects on the kidney

Cited by 16 publications

References 38 publications

Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approach

Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approach

“Post-COVID syndrome”: The focus is on musculoskeletal pain

Chronic Musculoskeletal Pain Associated with a Previous SARS-CoV-2 Infection

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