COVID 19 disease independently predicted endothelial dysfunction measured by flow-mediated dilatation

Ergül, Elif; Yılmaz, Ahmet; Öğütveren, Muhammet Mürsel; Emlek, Nadir; Kostakoğlu, Uğur; Çetin, Mustafa

doi:10.1007/s10554-021-02356-3

Cited by 25 publications

(28 citation statements)

References 30 publications

(38 reference statements)

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“…Endothelial dysfunctions occur in acute COVID-19 infections [ 48 , 49 , 50 , 51 , 52 , 53 ]. Endothelial dysfunctions caused by persistent endotheliitis could explain many of the symptoms of long COVID [ 54 , 55 , 56 , 57 , 58 ]. Melatonin activates nuclear factor erythroid-derived 2-like 2 (NRF2) [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID

et al. 2022

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Acute SARS-CoV-2 infections in children and adolescents are usually mild. However, they can suffer from ongoing symptoms, generally referred to as long COVID. Sleep disorders are one of the most frequent complaints in long COVID although precise data are missing. We assessed the sleep behavior of children and adolescents who presented at our outpatient clinic between January 2021 and May 2022 with the Children’s Sleep Habits Questionnaire (CSHQ-DE). We compared the sleep behavior at three different time points: pre-COVID-19; post-COVID-19 at the initial presentation; and post-COVID-19 at re-presentation. Data from 45 patients were analyzed. Of those, 64% were female and the median age was 10 years (range: 0–18 years). Asymptomatic or mild COVID-19 disease was experienced in 89% of patients; 11% experienced moderate disease. The initial presentation occurred at a median of 20.4 weeks (6 weeks–14 months) after the infection. The CSHQ-DE score increased significantly from pre-COVID-19 (45.82 ± 8.7 points) to post-COVID-19 (49.40 ± 8.3 points; p ≤ 0.01). The score then normalized at re-presentation (46.98 ± 7.8; p = 0.1). The greatest changes were seen in the CSHQ-DE subscale score “daytime sleepiness”. Our data showed that children and adolescents with long COVID often suffer from sleep disturbances. For most children and adolescents, these sleep disorders decreased over time without any further medical intervention aside from a basic sleep consultation.

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Section: Discussionmentioning

confidence: 99%

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID

et al. 2022

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“…Isso levanta a questão sobre a possibilidade de a doença ter efeitos anormais de longo prazo na função vascular. Achados semelhantes foram reportados por Ergul et al, 8 que avaliaram 63 pacientes que tiveram COVID-19 dois meses após a recuperação e identificaram a infeção por COVID-19 e o aumento do índice de massa corporal como preditores independentes de disfunção endotelial avaliados pela DFM. 8 Da mesma forma, Riou et al, 9 encontraram uma redução significativa na DFM de 16 pacientes com COVID-19 leve a moderada, enquanto a DFM tendia a ser menor em nove pacientes com COVID-19 grave a crítica três meses após o início da doença.…”

Section: Mansiroglu Et Al Dilatação Fluxo-mediada Em Covid-19unclassified

“…Achados semelhantes foram reportados por Ergul et al, 8 que avaliaram 63 pacientes que tiveram COVID-19 dois meses após a recuperação e identificaram a infeção por COVID-19 e o aumento do índice de massa corporal como preditores independentes de disfunção endotelial avaliados pela DFM. 8 Da mesma forma, Riou et al, 9 encontraram uma redução significativa na DFM de 16 pacientes com COVID-19 leve a moderada, enquanto a DFM tendia a ser menor em nove pacientes com COVID-19 grave a crítica três meses após o início da doença. 9 Ao contrário desses relatos, o presente estudo se concentrou em pacientes com COVID-19 leve, não hospitalizados, 35 dias (25-178) após o início da doença.…”

Section: Mansiroglu Et Al Dilatação Fluxo-mediada Em Covid-19unclassified

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Avaliação da Disfunção Endotelial em Casos de COVID-19 com Dilatação Fluxo-Mediada

Mansıroğlu¹,

Seymen²,

Sıncer³

et al. 2022

Arquivos Brasileiros De Cardiologia

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Resumo Fundamento: Sabe-se que a inflamação desempenha um papel crucial em muitas doenças, incluindo a COVID-19. Objetivo: Utilizando a dilatação fluxo-mediada (DFM), objetivou-se avaliar os efeitos da inflamação na função endotelial de pacientes com COVID-19. Métodos: Este estudo foi realizado com um total de 161 indivíduos, dos quais 80 foram diagnosticados com COVID-19 nos últimos seis meses (48 mulheres e 32 homens com idade média de 32,10±5,87 anos) e 81 eram controles saudáveis (45 mulheres e 36 homens com idade média de 30,51±7,33 anos). Os achados do ecocardiograma transtorácico e da DFM foram analisados em todos os indivíduos. Resultados com p<0,05 foram considerados estatisticamente significantes. Resultados: O ecocardiograma e a DFM do grupo COVID-19 foram realizados 35 dias (intervalo: 25–178) após o diagnóstico. Não houve diferença estatisticamente significativa nos parâmetros ecocardiográficos. Em contraste, a DFM (%) foi significativamente maior no grupo controle (9,52±5,98 versus 12,01±6,18; p=0,01). Na análise multivariada com o modelo stepwise progressivo, a DFM foi significativamente diferente no grupo controle em relação ao grupo COVID-19 (1,086 (1,026–1,149), p=0,04). O teste de correlação de Spearman indicou que a DFM (r=0,27; p=0,006) apresentou correlação positiva fraca com a presença de COVID-19. Conclusão: Os achados deste estudo apontam para disfunção endotelial induzida por COVID-19, avaliada por DFM, na fase inicial de recuperação.

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“…Endothelial dysfunction occurs in acute COVID-19 infection [46,47,4,8,49,50,51,52]. Endothelial dysfunction caused by persistent endotheliitis could explain many of the symptoms of long COVID [53,54,55,56]. Melatonin activates Nuclear factor erythroid-derived 2-like 2 (NRF2) [37].…”

Section: Treatment Recommendationsmentioning

confidence: 99%

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19

Werner¹,

Doerfel²,

Biedermann³

et al. 2022

Preprint

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Acute SARS-CoV-2 infections in children and adolescents are usually mild. However, they can suffer from ongoing symptoms generally referred as long COVID. Sleep disorders are one of the most frequent complaints in long COVID although precise data are missing. We assessed the sleep behavior of children and adolescents who presented at our outpatient clinic between January 2021 and May 2022 with the Children's Sleep Habits Questionnaire (CSHQ-DE). We compared sleep behavior at three different time points: pre-COVID-19, post-COVID-19 at initial presentation and post-COVID-19 at re-presentation. Data from 45 patients were analyzed. Of those, 64% were female and the median age was 10 years (range 0-18 years). Asymptomatic or mild COVID-19 disease was experienced in 89% of patients, whilst 11% experienced moderate disease. Initial presentation occurred at a median of 20.4 weeks (6 weeks - 14 months) after infection. The CSHQ-DE score increased significantly from pre-COVID-19 (45.82+8.7 points) to post-COVID-19 (49.40+8.3 points; p=&lt;0.01). The score then normalized at re-presentation (46.98+7.8; p=0.1). The greatest changes were seen in the CSHQ-DE subscale score "daytime sleepiness". Our data show that children and adolescents with long COVID often suffer from sleep disturbance. For most children and adolescents these sleep disorders decreased over time without further medical intervention, aside from a basic sleep consultation.

show abstract

COVID 19 disease independently predicted endothelial dysfunction measured by flow-mediated dilatation

Cited by 25 publications

References 30 publications

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID

Avaliação da Disfunção Endotelial em Casos de COVID-19 com Dilatação Fluxo-Mediada

The CSHQ-DE Questionnaire Uncovers Relevant Sleep Disorders in Children and Adolescents with Long COVID-19

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