COVID-19 Disease due to SARS-CoV-2 (Novel Coronavirus)

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

“…Coronaviruses are a group of enveloped viruses named for their coronary appearance with positive single-stranded RNA genomes [2]. In addition to six known strains of coronaviruses that are infectious to humans, a novel coronavirus (SARS-CoV-2) was detected recently in Wuhan, China [3,4]. Like the other two highly pathogenic coronaviruses SARS-CoV and MERS-CoV, SARS-CoV-2 also caused severe respiratory illness and even death.…”

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

“…Several reports have suggested that person-to-person transmission is a likely route for spreading COVID-19 infection. This is supported by cases that occurred within families and among people who did not visit the wet animal market in Wuhan [13,21]. Person-to-person transmission occurs primarily via direct contact or through droplets spread by coughing or sneezing from an infected individual.…”

“…It was shorter among patients > 70-years old compared with those under the age of 70 [8]. The most common symptoms at onset of COVID-19 illness are fever, cough, and fatigue, while other symptoms include sputum production, headache, haemoptysis, diarrhoea, dyspnoea, and lymphopenia [5,6,8,13]. Clinical features revealed by a chest CT scan presented as pneumonia, however, there were abnormal features such as RNAaemia, acute respiratory distress syndrome, acute cardiac injury, and incidence of grand-glass opacities that led to death [6].…”

“…Physical contact with wet and contaminated objects should be considered in dealing with the virus, especially agents such as faecal and urine samples that can potentially serve as an alternative route of transmission [15,16]. China and other countries including the US have implemented major prevention and control measures including travel screenings to control further spread of the virus [13]. Epidemiological changes in COVID-19 infection should be monitored taking into account potential routes of transmission and subclinical infections, in addition to the adaptation, evolution, and virus spread among humans and possible intermediate animals and reservoirs.…”

Coronavirus 2019-nCoV: A brief perspective from the front line

“…Most of the confirmed patients suffered from pneumonia (76.4%), and were characterized with groundglass opacity (50.0%) and bilateral patchy shadowing (46.0%) in the chest CT, and even subsegmental consolidation in severe patients. 24,26 To date, most of these patients had a good prognosis. However, the mortality rate was higher in elder patients with chronic diseases (diabetes, hypertension and angiocardiopathy, etc.)…”