COVID-19 combined with liver injury: Current challenges and management

Deng, Man-Ling; Chen, Yongjun; Yang, Meiling; Liu, Yiwen; Chen, Hui; Tang, Xiao‐Qing

doi:10.12998/wjcc.v9.i15.3487

Cited by 5 publications

(4 citation statements)

References 63 publications

(77 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the definition of liver injury in COVID-19 patients has not been clearly established yet. Some researchers defined it, as any increase of liver enzymes above the upper limit of normal (ULN), while others, as an increase, at least 2 or 3 times above the ULN[ 8 - 12 ]. Moreover, the different statistical time points across the studies, could also affect the incidence of liver injury[ 8 ].…”

Section: Prevalence and Risk Factorsmentioning

confidence: 99%

“…Some researchers defined it, as any increase of liver enzymes above the upper limit of normal (ULN), while others, as an increase, at least 2 or 3 times above the ULN[ 8 - 12 ]. Moreover, the different statistical time points across the studies, could also affect the incidence of liver injury[ 8 ]. As a consequence, the prevalence of liver damage varies across studies.…”

Section: Prevalence and Risk Factorsmentioning

confidence: 99%

See 1 more Smart Citation

COVID-19 and liver injury: An ongoing challenge

Papagiouvanni¹,

Kotoulas²,

Pataka³

et al. 2023

World J Gastroenterol

View full text Add to dashboard Cite

The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in December 2019, in Wuhan, China. The virus was rapidly spread worldwide, causing coronavirus disease 2019 (COVID-19) pandemic. Although COVID-19 is presented, usually, with typical respiratory symptoms ( i.e. , dyspnea, cough) and fever, extrapulmonary manifestations are also encountered. Liver injury is a common feature in patients with COVID-19 and ranges from mild and temporary elevation of liver enzymes to severe liver injury and, even, acute liver failure. The pathogenesis of liver damage is not clearly defined; multiple mechanisms contribute to liver disorder, including direct cytopathic viral effect, cytokine storm and immune-mediated hepatitis, hypoxic injury, and drug-induced liver toxicity. Patients with underlying chronic liver disease ( i.e. , cirrhosis, non-alcoholic fatty liver disease, alcohol-related liver disease, hepatocellular carcinoma, etc .) may have greater risk to develop both severe COVID-19 and further liver deterioration, and, as a consequence, certain issues should be considered during disease management. The aim of this review is to present the prevalence, clinical manifestation and pathophysiological mechanisms of liver injury in patients with SARS-CoV-2 infection. Moreover, we overview the association between chronic liver disease and SARS-CoV-2 infection and we briefly discuss the management of liver injury during COVID-19.

show abstract

Section: Prevalence and Risk Factorsmentioning

confidence: 99%

Section: Prevalence and Risk Factorsmentioning

confidence: 99%

COVID-19 and liver injury: An ongoing challenge

Papagiouvanni¹,

Kotoulas²,

Pataka³

et al. 2023

World J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…32 Severe hypoxic environment in ARDS patients led to hepatic ischemia-reperfusion injury. 18,33 Oxygen partial pressure gradient metabolism exists in the liver, which is sensitive to oxygen concentration. 12 A-aDO 2 is an indication of treatment effectiveness in COVID-19 patients and may be used to assess the degree of hypoxia since it rises with disease severity.…”

Section: Complications Of Severe Patientsmentioning

confidence: 99%

“…Especially upregulation of IL‐6, IL‐8, MCP‐1, and TNF‐α, implying the occurrence of cytokine storm 32 . Severe hypoxic environment in ARDS patients led to hepatic ischemia‐reperfusion injury 18,33 . Oxygen partial pressure gradient metabolism exists in the liver, which is sensitive to oxygen concentration 12 .…”

Section: Etiology Of Covid‐19 Related Liver Injurymentioning

confidence: 99%

COVID‐19‐associated liver injury: Adding fuel to the flame

Wang,

Shen,

et al. 2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

COVID‐19 is mainly characterized by respiratory disorders and progresses to multiple organ involvement in severe cases. With expansion of COVID‐19 and SARS‐CoV‐2 research, correlative liver injury has been revealed. It is speculated that COVID‐19 patients exhibited abnormal liver function, as previously observed in the SARS and MERS pandemics. Furthermore, patients with underlying diseases such as chronic liver disease are more susceptible to SARS‐CoV‐2 and indicate a poor prognosis accompanied by respiratory symptoms, systemic inflammation, or metabolic diseases. Therefore, COVID‐19 has the potential to impair liver function, while individuals with preexisting liver disease suffer from much worse infected conditions. COVID‐19 related liver injury may be owing to direct cytopathic effect, immune dysfunction, gut−liver axis interaction, and inappropriate medication use. However, discussions on these issues are infancy. Expanding research have revealed that angiotensin converting enzyme 2 (ACE2) expression mediated the combination of virus and target cells, iron metabolism participated in the virus life cycle and the fate of target cells, and amino acid metabolism regulated immune response in the host cells, which are all closely related to liver health. Further exploration holds great significance in elucidating the pathogenesis, facilitating drug development, and advancing clinical treatment of COVID‐19‐related liver injury. This article provides a review of the clinical and laboratory hepatic characteristics in COVID‐19 patients, describes the etiology and impact of liver injury, and discusses potential pathophysiological mechanisms.

show abstract

Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1 and Dipeptidyl Peptidase 4

Pan

Song

et al. 2022

Engineering

View full text Add to dashboard Cite

COVID-19 combined with liver injury: Current challenges and management

Cited by 5 publications

References 63 publications

COVID-19 and liver injury: An ongoing challenge

COVID-19 and liver injury: An ongoing challenge

COVID‐19‐associated liver injury: Adding fuel to the flame

Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1 and Dipeptidyl Peptidase 4

Contact Info

Product

Resources

About