COVID-19 + Cirrhosis = Excess Hospital Confinement, Excess Casualties

Gonzalez, Humberto C.; Trudeau, Sheri

doi:10.1007/s10620-023-08106-w

Cited by 1 publication

(1 citation statement)

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“…Another fundamental issue is that a potential influence of alcohol use disorder (AUD) on the pattern of liver injury in the case of underlying COVID-19 and possible differences in hepatic manifestation of the disease regarding a previous alcohol abuse history or its absence must be clarified. The inflammatory background of these two conditions appears to be of crucial importance in relation to searching for potential dependencies, even though it can only be speculated which factor is this triggering one: ALD or coronavirus infection [218][219][220]. The data concerning this aspect are rather scarce, nevertheless some attempts to identify the alcoholic background of hepatic complications due to infection with SARS-CoV-2 have already been made.…”

Section: Coronavirus In Ald Patientsmentioning

confidence: 99%

COVID-19, Possible Hepatic Pathways and Alcohol Abuse—What Do We Know up to 2023?

Michalak,

Lach,

Szczygieł

et al. 2024

IJMS

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The pandemic period due to coronavirus disease 2019 (COVID-19) revolutionized all possible areas of global health. Significant consequences were also related to diverse extrapulmonary manifestations of this pathology. The liver was found to be a relatively common organ, beyond the respiratory tract, affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Multiple studies revealed the essential role of chronic liver disease (CLD) in the general outcome of coronavirus infection. Present concerns in this field are related to the direct hepatic consequences caused by COVID-19 and pre-existing liver disorders as risk factors for the severe course of the infection. Which mechanism has a key role in this phenomenon—previously existing hepatic disorder or acute liver failure due to SARS-CoV-2—is still not fully clarified. Alcoholic liver disease (ALD) constitutes another not fully elucidated context of coronavirus infection. Should the toxic effects of ethanol or already developed liver cirrhosis and its consequences be perceived as a causative or triggering factor of hepatic impairment in COVID-19 patients? In the face of these discrepancies, we decided to summarize the role of the liver in the whole picture of coronavirus infection, paying special attention to ALD and focusing on the pathological pathways related to COVID-19, ethanol toxicity and liver cirrhosis.

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Section: Coronavirus In Ald Patientsmentioning

confidence: 99%