COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis

Becker, Sabeth; Jonigk, Danny; Luft, Angelina; Dübbel, Lena; Werlein, Christopher; Malik, Eduard; Schild-Suhren, Meike

doi:10.1016/j.jri.2022.103763

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…In Louisiana, over 98% of PCL was diagnosed in women aged 18–65, with women aged 20–34 having the highest incidence rates ( 21 ). Studies found that SARS-CoV-2, the causative agent of COVID-19, could directly infect the cervical epithelium or dysregulate the immune system by preoccupying and exhausting the system resulting in cervical dysplasia or rapid progression of existing lesions ( 22 – 24 ). The main risk factor for acquiring PCL is human papillomavirus (HPV) infection.…”

Section: Introductionmentioning

confidence: 99%

Racial/ethnic and socioeconomic disparities in COVID-19 infections among working-age women with precancerous cervical lesion in Louisiana: analysis of more than two years of COVID-19 data

et al. 2023

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BackgroundPrecancerous cervical lesion (PCL) is common in working-age and minority women. In Louisiana, 98% of PCL cases were diagnosed at age 18–65 with over 90% of them being human papillomavirus (HPV)-related. PCL women represent those who may be immunocompromised from the precancerous condition and thus more vulnerable to SARS-CoV-2. Most studies evaluating racial disparities for COVID-19 infection have only used data prior to vaccine availability. This study assessed disparities by race/ethnicity and socioeconomic status (SES) in COVID-19 infections among working-age PCL women for pre- and post-COVID-19 vaccine availability.MethodsLouisiana women aged 18–65 with PCL diagnosed in 2009–2021 were linked with the Louisiana statewide COVID-19 database to identify those with positive COVID-19 test. Race/ethnicity was categorized as non-Hispanic white (NHW), non-Hispanic black (NHB), Hispanic, and others. The census tract SES quintiles were created based on American Community Survey estimates. Logistic regression was employed to assess the racial/ethnic and SES differences in COVID-19 infections.ResultsOf 14,669 eligible PCL women, 30% were tested COVID-19 positive. NHB had the highest percentage of COVID-19 infection (34.6%), followed by NHW (27.7%). The infection percentage was inversely proportional to SES, with 32.9% for women having the lowest SES and 26.8% for those with the highest SES. NHB women and those with lower SES had higher COVID-19 infection than their counterparts with an aOR of 1.37 (95% CI 1.25–1.49) and 1.21 (95% CI 1.07–1.37), respectively. In the pre-vaccine period, NHB and Hispanic women had higher odds of infection than NHW women. However, after the vaccine was implemented, the significant racial/ethnic and SES differences in COVID-19 infections still existed in PCL women residing in non-Greater New Orleans area.ConclusionsThere are substantial variations in racial/ethnic and SES disparities in COVID-19 infections among working-age women with PCL, even after vaccine implementation. It is imperative to provide public health interventions and resources to reduce this unequal burden for this vulnerable population.

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Section: Introductionmentioning

confidence: 99%

Racial/ethnic and socioeconomic disparities in COVID-19 infections among working-age women with precancerous cervical lesion in Louisiana: analysis of more than two years of COVID-19 data

et al. 2023

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“…The hypothesis that other DNA oncoviruses, such as human papillomavirus (HPV), may also take advantage of the immune system exhaustion induced by COVID-19 is under investigation [ 72 ], as known HPV can reactivate in the course of AIDS or graft-versus-host disease [ 73 , 74 , 75 ]. From preliminary data in a lymphopenic setting, COVID-19 can lead to rapid progression of HPV-positive cervical intraepithelial neoplasia toward microinvasive carcinoma [ 76 ]. Therefore, this further aspect should be deeply explored in the context of cervical cancer screening programs.…”

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confidence: 99%

SARS-CoV-2 Induced Herpes Virus Reactivations and Related Implications in Oncohematology: When Lymphocytopenia Sets in and Immunosurveillance Drops Out

Roncati,

Sweidan,

Tchawa

et al. 2023

Microorganisms

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The Impact of the COVID-19 Pandemic on Oral and Oropharyngeal Cancer

McIlvanna,

McCarthy,

Gurzawska-Comis

2023

Curr Oral Health Rep

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Purpose of Review To describe the global impact of COVID-19 on oral cancer incidence and prognosis and to inform strategies for early detection and prevention. Recent Findings There is international evidence of delayed diagnosis and more advanced oral tumours presenting during the pandemic. Lockdowns were also associated with delayed surgeries and compromised treatment. School closures during the pandemic resulted in a rapid decline of human papillomavirus (HPV) vaccine coverage among adolescents globally. There was a rise in risk factor uptake in the form of tobacco use and alcohol consumptions across many parts of the world to manage stress and boredom during the pandemic. The economic fallout from the pandemic is another barrier to dental access and therefore early cancer detection. Summary The full impact of the pandemic on oral cancer incidence and mortality may not be seen for some time. Strategies aimed at prevention and early detection of oral cancer should be prioritised.

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COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis

Cited by 4 publications

References 43 publications

Racial/ethnic and socioeconomic disparities in COVID-19 infections among working-age women with precancerous cervical lesion in Louisiana: analysis of more than two years of COVID-19 data

Racial/ethnic and socioeconomic disparities in COVID-19 infections among working-age women with precancerous cervical lesion in Louisiana: analysis of more than two years of COVID-19 data

SARS-CoV-2 Induced Herpes Virus Reactivations and Related Implications in Oncohematology: When Lymphocytopenia Sets in and Immunosurveillance Drops Out

The Impact of the COVID-19 Pandemic on Oral and Oropharyngeal Cancer

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