Background
The long-term effects of COVID-19 on physical fitness are unclear, and the impact of vaccination on that relationship is uncertain.
Methods
We compared survey responses in a one-year study of U.S. military service members with (n = 1923) and without (n = 1591) a history of SARS-CoV-2 infection. We fit Poisson regression models to estimate the association between history of SARS-CoV-2 infection and fitness impairment, adjusting for time-since-infection, demographics, and baseline health.
Results
The participants in this analysis were primarily young adults aged 18-39 (75%) and 71.5% were male. Participants with a history of SARS-CoV-2 infection were more likely to report difficulty exercising (38.7% vs 18.4%, p < 0.01), difficulty performing daily activities (30.4% vs 12.7%, p < 0.01), and decreased fitness test (FT) scores (42.7% vs 26.2%, p < 0.01) than those without a history of infection. SARS-CoV-2 infected participants were at higher risk of these outcomes after adjusting for other factors (unvaccinated: exercising - adjusted risk ratio (aRR) 3.99, 95%CI 3.36-4.73; activities - aRR 5.02, 95%CI 4.09-6.16; FT affected - aRR 2.55, 95%CI 2.19-2.98). Among SARS-CoV-2 positive participants, full vaccination prior to infection was associated with a lower risk of post-COVID-19 fitness impairment (fully vaccinated: exercise: aRR 0.81, 95%CI 0.70-0.95; activities: aRR 0.76, 95%CI 0.64-0.91; FT: aRR 0.87, 95%CI 0.76-1.00; boosted: exercise: aRR 0.62, 95%CI 0.51-0.74; activities: aRR 0.52, 95%CI 0.41-0.65; FT: aRR 0.59, 95%CI 0.49-0.70).
Conclusions and Relevance
In this study of generally young, healthy military service members, SARS-CoV-2 infection was associated with lower self-reported fitness and exercise capacity; vaccination and boosting were associated with lower risk of self-reported fitness loss.